Cryo-EM structure of CB1-beta-arrestin1 complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8wu1
Q-score: 0.473
Liao YY, Zhang H, Shen Q, Cai C, Ding Y, Shen DD, Guo J, Qin J, Dong Y, Zhang Y, Li XM
Cell (2023) 186 pp. 5784-5797.e17 [ DOI: doi:10.1016/j.cell.2023.11.017 Pubmed: 38101408 ]
- Cannabinoid receptor 1,vasopressin v2 receptor (50 kDa, Protein from Homo sapiens)
- Beta-arrestin-1 (44 kDa, Protein from Bos taurus)
- Fab30 heavy chain (25 kDa, Protein from Homo sapiens)
- Cryo-em structure of human cannabinoid receptor 1 with effector protein (Complex from Bos taurus)
- Methyl n-{1-[(4-fluorophenyl)methyl]-1h-indazole-3-carbonyl}-3-methyl-l-valinate (397 Da, Ligand)
- Fab30 light chain (23 kDa, Protein from Homo sapiens)
Structural insights into human brain gut peptide cholecystokinin receptors
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8ia7
Q-score: 0.522
Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM
Cell Discov (2022) 8 pp. 55-55 [ DOI: doi:10.1038/s41421-022-00420-3 Pubmed: 35672283 ]
- Gastrin/cholecystokinin type b receptor (48 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G subunit q (gi1-gq chimeric) (Complex from Homo sapiens)
- Cck-8 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Human brain gut peptide cholecystokinin receptors (Complex)
- Cck-8 (Complex)
- Scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cholecystokinin receptor (Complex from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
Structural insights into human brain gut peptide cholecystokinin receptors
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7xou
Q-score: 0.434
Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM
Cell Discov (2022) 8 pp. 55-55 [ Pubmed: 35672283 DOI: doi:10.1038/s41421-022-00420-3 ]
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholecystokinin receptor type a (47 kDa, Protein from Homo sapiens)
- Human brain gut peptide cholecystokinin receptors (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Cholecystokinin receptor1 (Complex from Homo sapiens)
- Nanobody35 (Complex)
- Cck-8 (1 kDa, Protein from Homo sapiens)
- Nanobody 35 (13 kDa, Protein from synthetic construct)
- Gs protein (Complex from Homo sapiens)
- Cck-8 (Complex)
Structural insights into human brain gut peptide cholecystokinin receptors
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7xov
Q-score: -0.079
Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM
Cell Discov (2022) 8 pp. 55-55 [ Pubmed: 35672283 DOI: doi:10.1038/s41421-022-00420-3 ]
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholecystokinin receptor1 (Complex)
- Cholecystokinin receptor type a (47 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 2-[2-[[4-(4-chloranyl-2,5-dimethoxy-phenyl)-5-(2-cyclohexylethyl)-1,3-thiazol-2-yl]carbamoyl]-5,7-dimethyl-indol-1-yl]ethanoic acid (610 Da, Ligand)
- Cholecystokinin receptor1 (Complex from Homo sapiens)
- Nanobody35 (Complex)
- Nanobody 35 (13 kDa, Protein from synthetic construct)
- Gs protein (Complex from Homo sapiens)
Structural insights into human brain gut peptide cholecystokinin receptors
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7xow
Q-score: 0.499
Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM
Cell Discov (2022) 8 pp. 55-55 [ Pubmed: 35672283 DOI: doi:10.1038/s41421-022-00420-3 ]
- Gastrin (2 kDa, Protein from Homo sapiens)
- Gastrin/cholecystokinin type b receptor (48 kDa, Protein from Homo sapiens)
- Human brain gut peptide cholecystokinin receptors (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Gastrin (Complex)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Gs protein (Complex from Homo sapiens)
- Scfc16 (Complex from Mus musculus)
- Cholecystokinin receptor (Complex from Homo sapiens)