Structural insights into human brain gut peptide cholecystokinin receptors
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7xou
Q-score: 0.434
Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM
Cell Discov (2022) 8 pp. 55-55 [ Pubmed: 35672283 DOI: doi:10.1038/s41421-022-00420-3 ]
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholecystokinin receptor type a (47 kDa, Protein from Homo sapiens)
- Human brain gut peptide cholecystokinin receptors (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Cholecystokinin receptor1 (Complex from Homo sapiens)
- Nanobody35 (Complex)
- Cck-8 (1 kDa, Protein from Homo sapiens)
- Nanobody 35 (13 kDa, Protein from synthetic construct)
- Gs protein (Complex from Homo sapiens)
- Cck-8 (Complex)
Structural insights into human brain gut peptide cholecystokinin receptors
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7xov
Q-score: -0.079
Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM
Cell Discov (2022) 8 pp. 55-55 [ Pubmed: 35672283 DOI: doi:10.1038/s41421-022-00420-3 ]
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholecystokinin receptor1 (Complex)
- Cholecystokinin receptor type a (47 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 2-[2-[[4-(4-chloranyl-2,5-dimethoxy-phenyl)-5-(2-cyclohexylethyl)-1,3-thiazol-2-yl]carbamoyl]-5,7-dimethyl-indol-1-yl]ethanoic acid (610 Da, Ligand)
- Cholecystokinin receptor1 (Complex from Homo sapiens)
- Nanobody35 (Complex)
- Nanobody 35 (13 kDa, Protein from synthetic construct)
- Gs protein (Complex from Homo sapiens)
Structural insights into human brain gut peptide cholecystokinin receptors
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7xow
Q-score: 0.499
Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM
Cell Discov (2022) 8 pp. 55-55 [ Pubmed: 35672283 DOI: doi:10.1038/s41421-022-00420-3 ]
- Gastrin (2 kDa, Protein from Homo sapiens)
- Gastrin/cholecystokinin type b receptor (48 kDa, Protein from Homo sapiens)
- Human brain gut peptide cholecystokinin receptors (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Gastrin (Complex)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Gs protein (Complex from Homo sapiens)
- Scfc16 (Complex from Mus musculus)
- Cholecystokinin receptor (Complex from Homo sapiens)
catalytic core of human telomerase holoenzyme
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 7v99
Q-score: 0.247
Wan F, Ding Y, Zhang Y, Wu Z, Li S, Yang L, Yan X, Lan P, Li G, Wu J, Lei M
Cell Res (2021) 31 pp. 1275-1290 [ Pubmed: 34782750 DOI: doi:10.1038/s41422-021-00586-7 ]
- Telomerase reverse transcriptase (127 kDa, Protein from Homo sapiens)
- Telomerase rna component (145 kDa, RNA from Homo sapiens)
- Primer dna (7 kDa, DNA from Homo sapiens)
- Histone h2a type 1-b/e (14 kDa, Protein from Homo sapiens)
- Catalytic core (Complex from Homo sapiens)
- Histone h2b type 1-k (13 kDa, Protein from Homo sapiens)
biogenesis module of human telomerase holoenzyme
Resolution: 3.94 Å
EM Method: Single-particle
Fitted PDBs: 7v9a
Q-score: 0.254
Wan F, Ding Y, Zhang Y, Wu Z, Li S, Yang L, Yan X, Lan P, Li G, Wu J, Lei M
Cell Res (2021) 31 pp. 1275-1290 [ Pubmed: 34782750 DOI: doi:10.1038/s41422-021-00586-7 ]
- Telomerase rna component (145 kDa, RNA from Homo sapiens)
- H/aca ribonucleoprotein complex subunit 2 (17 kDa, Protein from Homo sapiens)
- Telomerase cajal body protein 1 (59 kDa, Protein from Homo sapiens)
- H/aca ribonucleoprotein complex subunit 1 (22 kDa, Protein from Homo sapiens)
- H/aca ribonucleoprotein complex subunit dkc1 (57 kDa, Protein from Homo sapiens)
- H/aca ribonucleoprotein complex subunit 3 (7 kDa, Protein from Homo sapiens)
- Biogenesis module (Complex from Homo sapiens)
Cryo-EM structure of SHIV-elicited RHA1.V2.01 in complex with HIV-1 Env BG505 DS-SOSIP.664
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6xrt
Q-score: 0.322
Roark RS, Li H, Williams WB, Chug H, Mason RD, Gorman J, Wang S, Lee FH, Rando J, Bonsignori M, Hwang KK, Saunders KO, Wiehe K, Moody MA, Hraber PT, Wagh K, Giorgi EE, Russell RM, Bibollet-Ruche F, Liu W, Connell J, Smith AG, DeVoto J, Murphy AI, Smith J, Ding W, Zhao C, Chohan N, Okumura M, Rosario C, Ding Y, Lindemuth E, Bauer AM, Bar KJ, Ambrozak D, Chao CW, Chuang GY, Geng H, Lin BC, Louder MK, Nguyen R, Zhang B, Lewis MG, Raymond DD, Doria-Rose NA, Schramm CA, Douek DC, Roederer M, Kepler TB, Kelsoe G, Mascola JR, Kwong PD, Korber BT, Harrison SC, Haynes BF, Hahn BH, Shaw GM
Science (2021) 371 [ Pubmed: 33214287 DOI: doi:10.1126/science.abd2638 ]
- Vrc01.23 light chain (11 kDa, Protein from Macaca mulatta)
- Hiv-1 envelope glycoprotein bg505 sosip.664 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of shiv-elicited rha1.v2.01 in complex with hiv-1 env bg505 ds-sosip.664 (Complex from Human immunodeficiency virus 1)
- Cryo-em structure of shiv-elicited rha1.v2.01 in complex with hiv-1 env bg505 ds-sosip (Complex)
- Vrc01.23 heavy chain (14 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp160 (53 kDa, Protein from Human immunodeficiency virus 1)
CryoEM structure of human PAC1 receptor in complex with maxadilan
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6m1h
Q-score: 0.423
Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang HW, Ma Y
Cell Res (2020) 30 pp. 436-445 [ Pubmed: 32047270 DOI: doi:10.1038/s41422-020-0280-2 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Maxadilan (6 kDa, Protein from Lutzomyia longipalpis)
- Pituitary adenylate cyclase-activating polypeptide type i receptor (47 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nanobody 35 (14 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Pacap38-pac1r complex (150 kDa, Complex from Homo sapiens)
CryoEM structure of human PAC1 receptor in complex with PACAP38
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6m1i
Q-score: 0.442
Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang HW, Ma Y
Cell Res (2020) 30 pp. 436-445 [ DOI: doi:10.1038/s41422-020-0280-2 Pubmed: 32047270 ]
- Pacap38-pac1r complex (150 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Pituitary adenylate cyclase-activating polypeptide type i receptor (47 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nanobody 35 (14 kDa, Protein from Lama glama)
- Pituitary adenylate cyclase-activating polypeptide (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Ribosome Structure bound to ABC-F protein.
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 5zlu
Q-score: 0.441
Su W, Kumar V, Ding Y, Ero R, Serra A, Lee BST, Wong ASW, Shi J, Sze SK, Yang L, Gao YG
PNAS (2018) 115 pp. 5157-5162 [ Pubmed: 29712846 DOI: doi:10.1073/pnas.1803313115 ]
- P-site trna (24 kDa, RNA from Thermus thermophilus HB8)
- 30s ribosomal protein s5 (17 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 30s ribosomal protein s20 (11 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l24 (12 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l4 (23 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l2 (30 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 23s ribosomal rna (935 kDa, RNA from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 30s ribosomal protein s18 (8 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 30s ribosomal protein s13 (14 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 30s ribosomal protein s7 (18 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l29 (8 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 30s ribosomal protein s19 (10 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l3 (22 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 30s ribosomal protein thx (3 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l5 (21 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l21 (11 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 30s ribosomal protein s3 (26 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l32 (6 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 30s ribosomal protein s10 (11 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 30s ribosomal protein s2 (29 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l23 (10 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- 30s ribosomal protein s8 (15 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 30s ribosomal protein s4 (24 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 30s ribosomal protein s14 type z (7 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l1 (24 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- Macrolide efflux protein (55 kDa, Protein from Pseudomonas aeruginosa)
- 30s ribosomal protein s11 (13 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- Bacterial ribosome in complex with msre (2 MDa, Complex from Thermus thermophilus)
- 50s ribosomal protein l19 (17 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l34 (6 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l25 (23 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 30s ribosomal protein s17 (12 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 30s ribosomal protein s15 (10 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l11 (15 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l22 (12 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l30 (6 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l10 (18 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l14 (13 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 30s ribosomal protein s16 (10 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l27 (9 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 5s ribosomal rna (39 kDa, RNA from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l31 (8 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l18 (12 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 30s ribosomal protein s9 (14 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l36 (4 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l35 (7 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l6 (19 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l13 (15 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 16s ribosomal rna (491 kDa, RNA from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l33 (6 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- Magnesium ion (24 Da, Ligand)
- Rna (25-mer) (8 kDa, RNA from Thermus thermophilus HB8)
- 50s ribosomal protein l20 (13 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l15 (16 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l16 (15 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 50s ribosomal protein l17 (13 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 30s ribosomal protein s12 (14 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))
- 30s ribosomal protein s6 (11 kDa, Protein from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579))