Cryo-EM structure of SARS-CoV-2 M (short conformation)bound to C1P
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 9ctu
Q-score: 0.433
Dutta M, Dolan KA, Amiar S, Bass EJ, Sultana R, Voth GA, Brohawn SG, Stahelin RV
bioRxiv (2024) [ Pubmed: 39574576 DOI: doi:10.1101/2024.11.04.620124 ]
- M protein (52 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Membrane protein (26 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- (2s,3r,4e)-2-(hexadecanoylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (617 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Short conformation fab heavy chain (27 kDa, Protein from Mus musculus)
- Short conformation fab light chain (26 kDa, Protein from Mus musculus)
Cryo-EM structure of SARS-CoV-2 M (long conformation) in the presence of C1P
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 9ctw
Q-score: 0.537
Dutta M, Dolan KA, Amiar S, Bass EJ, Sultana R, Voth GA, Brohawn SG, Stahelin RV
bioRxiv (2024) [ Pubmed: 39574576 DOI: doi:10.1101/2024.11.04.620124 ]
- M protein (52 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Long conformation fab heavy chain (28 kDa, Protein from Mus musculus)
- Membrane protein (26 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Long conformation fab light chain (26 kDa, Protein from Mus musculus)
Structure of SARS-CoV-2 M protein in lipid nanodiscs
Dolan KA, Dutta M, Kern DM, Kotecha A, Voth GA, Brohawn SG
bioRxiv (2022) [ DOI: 10.1101/2022.06.12.495841 ]
Image sets:
Cryo-EM structure of SARS-CoV-2 M protein in a lipid nanodisc
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8ctk
Q-score: 0.384
Dolan KA, Dutta M, Kern DM, Kotecha A, Voth GA, Brohawn SG
eLife (2022) 11 [ Pubmed: 36264056 DOI: doi:10.7554/eLife.81702 ]
- M protein (52 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Membrane protein (26 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 Å
Flores JA, Haddad BG, Dolan KA, Myers JB, Yoshioka CC, Copperman J, Zuckerman DM, Reichow SL
Nat Commun (2020) 11 [ Pubmed: 32859914 DOI: 10.1038/s41467-020-18120-5 ]
Image sets:
Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 angstroms
Resolution: 1.94 Å
EM Method: Single-particle
Fitted PDBs: 7jjp
Q-score: 0.681
Flores JA, Haddad BG, Dolan KA, Myers JB, Yoshioka CC, Copperman J, Zuckerman DM, Reichow SL
Nat Commun (2020) 11 pp. 4331-4331 [ DOI: doi:10.1038/s41467-020-18120-5 Pubmed: 32859914 ]
- Water (18 Da, Ligand)
- Gap junction alpha-8 protein (49 kDa, Protein from Ovis aries)
- 1,2-dimyristoyl-rac-glycero-3-phosphocholine (677 Da, Ligand)
- Dodecameric connexin-50 gap junction channel in msp1e1-lipid nanodisc (450 kDa, Complex from Ovis aries)
Sheep Connexin-50 at 2.5 angstroms resolution, Lipid Class 1
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7jlw
Q-score: 0.611
Flores JA, Haddad BG, Dolan KA, Myers JB, Yoshioka CC, Copperman J, Zuckerman DM, Reichow SL
Nat Commun (2020) 11 pp. 4331-4331 [ DOI: doi:10.1038/s41467-020-18120-5 Pubmed: 32859914 ]
- Water (18 Da, Ligand)
- Gap junction alpha-8 protein (49 kDa, Protein from Ovis aries)
- 1,2-dimyristoyl-rac-glycero-3-phosphocholine (677 Da, Ligand)
- Dodecameric connexin-50 gap junction channel complex (450 kDa, Complex from Ovis aries)
Sheep Connexin-50 at 2.5 angstroms reoslution, Lipid Class 2
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7jm9
Q-score: 0.586
Flores JA, Haddad BG, Dolan KA, Myers JB, Yoshioka CC, Copperman J, Zuckerman DM, Reichow SL
Nat Commun (2020) 11 pp. 4331-4331 [ DOI: doi:10.1038/s41467-020-18120-5 Pubmed: 32859914 ]
- Water (18 Da, Ligand)
- Gap junction alpha-8 protein (49 kDa, Protein from Ovis aries)
- 1,2-dimyristoyl-rac-glycero-3-phosphocholine (677 Da, Ligand)
- Dodecameric connexin-50 gap junction channel complex (450 kDa, Complex from Ovis aries)
Sheep Connexin-50 at 2.5 angstroms resolution, Lipid Class 3
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7jmc
Q-score: 0.602
Flores JA, Haddad BG, Dolan KA, Myers JB, Yoshioka CC, Copperman J, Zuckerman DM, Reichow SL
Nat Commun (2020) 11 pp. 4331-4331 [ DOI: doi:10.1038/s41467-020-18120-5 Pubmed: 32859914 ]
- Water (18 Da, Ligand)
- Gap junction alpha-8 protein (49 kDa, Protein from Ovis aries)
- 1,2-dimyristoyl-rac-glycero-3-phosphocholine (677 Da, Ligand)
- Dodecameric connexin-50 gap junction channel complex (450 kDa, Complex from Ovis aries)