Electron Microscopy Data Bank

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Human Anaphase-Promoting Complex/Cyclosome (APC/C) APC15 deletion mutant with Mitotic Checkpoint Complex (MCC) in a closed conformation.

Release date: Aug. 17, 2016
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 5khu
Q-score: 0.167

Yamaguchi M, VanderLinden R, Weissmann F, Qiao R, Dube P, Brown NG, Haselbach D, Zhang W, Sidhu SS, Peters JM, Stark H, Schulman BA

Mol Cell (2016) 63 pp. 593-607 [ Pubmed: 27522463 DOI: doi:10.1016/j.molcel.2016.07.003 ]

Sample:

Human anaphase-promoting complex/cyclosome (apc/c) apc15 deletion mutant with mitotic checkpoint complex (mcc) in a closed conformation. (1 MDa, Complex from Homo sapiens)

EMD-4022

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Human Anaphase-Promoting Complex/Cyclosome (APC/C) APC15 deletion mutant with Mitotic Checkpoint Complex (MCC) in an open conformation.

Release date: Aug. 17, 2016
Resolution: 9.0 Å
EM Method: Single-particle

Yamaguchi M, VanderLinden R, Weissmann F, Qiao R, Dube P, Brown NG, Haselbach D, Zhang W, Sidhu SS, Peters JM, Stark H, Schulman BA

Mol Cell (2016) 63 pp. 593-607 [ Pubmed: 27522463 DOI: doi:10.1016/j.molcel.2016.07.003 ]

Sample:

Human anaphase-promoting complex/cyclosome (apc/c) apc15 deletion mutant with mitotic checkpoint complex (mcc) in an open conformation. (1 MDa, Complex from Homo sapiens)

EMD-4023

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Human Anaphase-Promoting Complex/Cyclosome bound to Mitotic Checkpoint Complex (APC/C-MCC) in a closed conformation.

Release date: Aug. 17, 2016
Resolution: 9.0 Å
EM Method: Single-particle

Yamaguchi M, VanderLinden R, Weissmann F, Qiao R, Dube P, Brown NG, Haselbach D, Zhang W, Sidhu SS, Peters JM, Stark H, Schulman BA

Mol Cell (2016) 63 pp. 593-607 [ Pubmed: 27522463 DOI: doi:10.1016/j.molcel.2016.07.003 ]

Sample:

Human anaphase-promoting complex/cyclosome bound to mitotic checkpoint complex (apc/c-mcc) in a closed conformation. (1 MDa, Complex from Homo sapiens)

EMD-4024

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Human Anaphase-promoting complex/Cyclosome bound to Mitotic Checkpoint Complex(APC/C-MCC) in an open conformation.

Release date: Aug. 17, 2016
Resolution: 10.0 Å
EM Method: Single-particle

Yamaguchi M, VanderLinden R, Weissmann F, Qiao R, Dube P, Brown NG, Haselbach D, Zhang W, Sidhu SS, Peters JM, Stark H, Schulman BA

Mol Cell (2016) 63 pp. 593-607 [ Pubmed: 27522463 DOI: doi:10.1016/j.molcel.2016.07.003 ]

Sample:

Human anaphase-promoting complex/cyclosome bound to mitotic checkpoint complex(apc/c-mcc) in an open conformation. (1 MDa, Complex from Homo sapiens)

EMD-4025

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Human Anaphase-promoting complex/Cyclosome (APC/C) APC15 deletion mutant bound to the E2 UBE2C (aka UBCH10) poised for ubiquitin ligation to substrate.

Release date: Aug. 17, 2016
Resolution: 6.1 Å
EM Method: Single-particle
Fitted PDBs: 5khr
Q-score: 0.133

Yamaguchi M, VanderLinden R, Weissmann F, Qiao R, Dube P, Brown NG, Haselbach D, Zhang W, Sidhu SS, Peters JM, Stark H, Schulman BA

Mol Cell (2016) 63 pp. 593-607 [ Pubmed: 27522463 DOI: doi:10.1016/j.molcel.2016.07.003 ]

Sample:

Human anaphase-promoting complex/cyclosome (apc/c) apc15 deletion mutant bound to the e2 ube2c (aka ubch10) poised for ubiquitin ligation to substrate. (1 MDa, Complex from Homo sapiens)

EMD-4026

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Human Anaphase-Promoting Complex/Cyclosome (APC/C) APC15 deletion mutant bound to Mitotic Checkpoint Complex (MCC) and the E2 UBE2S poised for UB chain synthesis.

Release date: Aug. 17, 2016
Resolution: 5.7 Å
EM Method: Single-particle

Yamaguchi M, VanderLinden R, Weissmann F, Qiao R, Dube P, Brown NG, Haselbach D, Zhang W, Sidhu SS, Peters JM, Stark H, Schulman BA

Mol Cell (2016) 63 pp. 593-607 [ Pubmed: 27522463 DOI: doi:10.1016/j.molcel.2016.07.003 ]

Sample:

Human anaphase-promoting complex/cyclosome (apc/c) apc15 deletion mutant bound to mitotic checkpoint complex (mcc) and the e2 ube2s poised for ub chain synthesis. (1 MDa, Complex from Homo sapiens)

EMD-4027

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Human Anaphase-Promoting Complex/Cyclosome bound to Mitotic Checkpoint Complex (APC/C-MCC) and the E2 UBE2C (aka UBCH10) poised for ubiquitination of MCC's CDC20

Release date: Aug. 17, 2016
Resolution: 17.0 Å
EM Method: Single-particle

Yamaguchi M, VanderLinden R, Weissmann F, Qiao R, Dube P, Brown NG, Haselbach D, Zhang W, Sidhu SS, Peters JM, Stark H, Schulman BA

Mol Cell (2016) 63 pp. 593-607 [ Pubmed: 27522463 DOI: doi:10.1016/j.molcel.2016.07.003 ]

Sample:

Human anaphase-promoting complex/cyclosome bound to mitotic checkpoint complex (apc/c-mcc) and the e2 ube2c (aka ubch10) poised for ubiquitination of mcc's cdc20 (1 MDa, Complex from Homo sapiens)

EMD-4028

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Human Anaphase-Promoting Complex/Cyclosome (APC/C) APC15 deletion mutant bound to Mitotic Checkpoint Complex (MCC) and the E2 UBE2C (aka UBCH10) poised for ubiquitination of MCC's CDC20

Release date: Aug. 17, 2016
Resolution: 18.0 Å
EM Method: Single-particle

Yamaguchi M, VanderLinden R, Weissmann F, Qiao R, Dube P, Brown NG, Haselbach D, Zhang W, Sidhu SS, Peters JM, Stark H, Schulman BA

Mol Cell (2016) 63 pp. 593-607 [ Pubmed: 27522463 DOI: doi:10.1016/j.molcel.2016.07.003 ]

Sample:

Human anaphase-promoting complex/cyclosome (apc/c) apc15 deletion mutant bound to mitotic checkpoint complex (mcc) and the e2 ube2c (aka ubch10) poised for ubiquitination of mcc's cdc20 (1 MDa, Complex from Homo sapiens)

EMD-3432

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Anaphase-promoting complex/Cyclosome (APC/C)-CDH1-UBE2C (aka UBCH10)-substrate-Ubiquitin (variant)

Release date: July 20, 2016
Resolution: 6.4 Å
EM Method: Single-particle

Brown N, VanderLinden R, Watson E, Weissmann F, Ordureau A, Wu K-P, Yu S, Mercedi P, Harrison J, Davidson I, Coudevylle R, Lu Y, Dube P, Brunner M, Grace CRR, Miller D, Haselbach D, Jarvis M, Yamaguchi M, Yanishevski D, Petzold G, Sidhu S, Kuhlman B, Kirschner M, Harper JW, Peters J-M, Stark H, Schulman BA

Cell (2016) 165 pp. 1440-1453 [ Pubmed: 27259151 DOI: doi:10.1016/j.cell.2016.05.037 ]

Sample:

Anaphase-promoting complex/cyclosome (apc/c)-cdh1-ube2c (aka ubch10)-substrate-ubiquitin (variant) (1 MDa, Sample)
Anaphase promoting complex (1 MDa, Protein from Homo sapiens)

EMD-3433

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Anaphase-promoting complex/Cyclosome (APC/C)-CDH1-UBE2S-Ubiquitin (variant)-substrate

Release date: July 20, 2016
Resolution: 6.0 Å
EM Method: Single-particle
Fitted PDBs: 5l9t
Q-score: 0.02

Brown N, VanderLinden R, Watson E, Weissmann F, Ordureau A, Wu K-P, Yu S, Mercedi P, Harrison J, Davidson I, Coudevylle R, Lu Y, Dube P, Brunner M, Grace CRR, Miller D, Haselbach D, Jarvis M, Yamaguchi M, Yanishevski D, Petzold G, Sidhu S, Kuhlman B, Kirschner M, Harper JW, Peters J-M, Stark H, Schulman BA

Cell (2016) 165 pp. 1440-1453 [ Pubmed: 27259151 DOI: doi:10.1016/j.cell.2016.05.037 ]

Sample:

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