Structure of human full-length ancestral TRPV6 channel in apo open state
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 9cuh
Q-score: 0.56
Neuberger A, Shalygin A, Trofimov YA, Veretenenko II, Nadezhdin KD, Krylov NA, Gudermann T, Efremov RG, Chubanov V, Sobolevsky AI
Structure (2025) 33 pp. 91-103.e5 [ DOI: doi:10.1016/j.str.2024.10.018 Pubmed: 39500315 ]
- Calcium ion (40 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Ancestral htrpv6 tetramer in open apo state (370 kDa, Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily v member 6 (87 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Water (18 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Structure of human full-length ancestral TRPV6 channel in Calmodulin-bound state
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 9cui
Q-score: 0.468
Neuberger A, Shalygin A, Trofimov YA, Veretenenko II, Nadezhdin KD, Krylov NA, Gudermann T, Efremov RG, Chubanov V, Sobolevsky AI
Structure (2025) 33 pp. 91-103.e5 [ DOI: doi:10.1016/j.str.2024.10.018 Pubmed: 39500315 ]
- Ancestral htrpv6 tetramer in complex with calmodulin (Complex from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 6 (87 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Structure of human full-length derived TRPV6 channel in apo open state
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 9cuj
Q-score: 0.569
Neuberger A, Shalygin A, Trofimov YA, Veretenenko II, Nadezhdin KD, Krylov NA, Gudermann T, Efremov RG, Chubanov V, Sobolevsky AI
Structure (2025) 33 pp. 91-103.e5 [ DOI: doi:10.1016/j.str.2024.10.018 Pubmed: 39500315 ]
- Calcium ion (40 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Derived htrpv6 tetramer in open apo state (370 kDa, Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily v member 6 (87 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Structure of human full-length derived TRPV6 channel in Calmodulin-bound state
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 9cuk
Q-score: 0.482
Neuberger A, Shalygin A, Trofimov YA, Veretenenko II, Nadezhdin KD, Krylov NA, Gudermann T, Efremov RG, Chubanov V, Sobolevsky AI
Structure (2025) 33 pp. 91-103.e5 [ DOI: doi:10.1016/j.str.2024.10.018 Pubmed: 39500315 ]
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Derived htrpv6 tetramer in complex with calmodulin (370 kDa, Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 6 (87 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Human TRP channel TRPV6 in cNW30 nanodiscs inhibited by tetrahydrocannabivarin (THCV)
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8sp8
Q-score: 0.515
Neuberger A, Trofimov YA, Yelshanskaya MV, Khau J, Nadezhdin KD, Khosrof LS, Krylov NA, Efremov RG, Sobolevsky AI
Nat Commun (2023) 14 pp. 4630-4630 [ DOI: doi:10.1038/s41467-023-40362-2 Pubmed: 37532722 ]
- Transient receptor potential cation channel subfamily v member 6 (76 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Sample 1 (76 kDa, Complex from Homo sapiens)
- Tetrahydrocannabivarin (286 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8bk7
Q-score: 0.525
Torino S, Dhurandhar M, Stroobants A, Claessens R, Efremov RG
Nat Methods (2023) 20 pp. 1400-1408 [ DOI: doi:10.1038/s41592-023-01967-z Pubmed: 37592181 ]
- Beta-galactosidase (117 kDa, Protein from Escherichia coli K-12)
- Beta-galactosidase from e.coli (Complex from Escherichia coli)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8bk8
Q-score: 0.609
Torino S, Dhurandhar M, Stroobants A, Claessens R, Efremov RG
Nat Methods (2023) 20 pp. 1400-1408 [ DOI: doi:10.1038/s41592-023-01967-z Pubmed: 37592181 ]
- Beta-galactosidase (Complex from Escherichia coli)
- Beta-galactosidase (117 kDa, Protein from Escherichia coli)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8bkg
Q-score: 0.536
Torino S, Dhurandhar M, Stroobants A, Claessens R, Efremov RG
Nat Methods (2023) 20 pp. 1400-1408 [ DOI: doi:10.1038/s41592-023-01967-z Pubmed: 37592181 ]
- Beta-galactosidase (Complex from Escherichia coli)
- Beta-galactosidase (117 kDa, Protein from Escherichia coli K-12)
Alvinella pompejana nicotinic acetylcholine receptor Alpo4 in apo state (dataset 1)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8bx5
Q-score: 0.313
De Gieter S, Gallagher C, Wijckmans E, Pasini D, Ulens C, Efremov RG
eLife (2023) 12 [ DOI: doi:10.7554/eLife.86029 Pubmed: 37395731 ]
- Pentameric complex of alpo4 in apo state (270 kDa, Complex from Alvinella pompejana)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Water (18 Da, Ligand)
- Acetylcholine receptor (54 kDa, Protein from Alvinella pompejana)
Alvinella pompejana nicotinic acetylcholine receptor Alpo in apo state (dataset 2)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8bxb
Q-score: 0.4
De Gieter S, Gallagher C, Wijckmans E, Pasini D, Ulens C, Efremov RG
eLife (2023) 12 [ DOI: doi:10.7554/eLife.86029 Pubmed: 37395731 ]
- Acetylcholine receptor (54 kDa, Protein from Alvinella pompejana)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Water (18 Da, Ligand)
- Pentameric ligand-gated ion channel (270 kDa, Complex from Alvinella pompejana)