Human TRP channel TRPV6 in cNW30 nanodiscs inhibited by tetrahydrocannabivarin (THCV)
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8sp8
Q-score: 0.515
Neuberger A, Trofimov YA, Yelshanskaya MV, Khau J, Nadezhdin KD, Khosrof LS, Krylov NA, Efremov RG, Sobolevsky AI
Nat Commun (2023) 14 pp. 4630-4630 [ DOI: doi:10.1038/s41467-023-40362-2 Pubmed: 37532722 ]
- Transient receptor potential cation channel subfamily v member 6 (76 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Sample 1 (76 kDa, Complex from Homo sapiens)
- Tetrahydrocannabivarin (286 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Cryo-EM structure of human TRPV6 in complex with the natural phytoestrogen genistein
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8foa
Q-score: 0.546
Neuberger A, Trofimov YA, Yelshanskaya MV, Nadezhdin KD, Krylov NA, Efremov RG, Sobolevsky AI
Nat Commun (2023) 14 pp. 2659-2659 [ Pubmed: 37160865 DOI: doi:10.1038/s41467-023-38352-5 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Genistein (270 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 6 (83 kDa, Protein from Homo sapiens)
- Sample 1 (83 kDa, Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Cryo-EM structure of human TRPV6 in the open state
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8fob
Q-score: 0.468
Neuberger A, Trofimov YA, Yelshanskaya MV, Nadezhdin KD, Krylov NA, Efremov RG, Sobolevsky AI
Nat Commun (2023) 14 pp. 2659-2659 [ Pubmed: 37160865 DOI: doi:10.1038/s41467-023-38352-5 ]
- Calcium ion (40 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 6 (83 kDa, Protein from Homo sapiens)
- Sample 1 (83 kDa, Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Water (18 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 4 degrees Celsius
Resolution: 1.98 Å
EM Method: Single-particle
Fitted PDBs: 7mij
Q-score: 0.661
Nadezhdin KD, Neuberger A, Trofimov YA, Krylov NA, Sinica V, Kupko N, Vlachova V, Zakharian E, Efremov RG, Sobolevsky AI
Nat Struct Mol Biol (2021) 28 pp. 564-572 [ DOI: doi:10.1038/s41594-021-00615-4 Pubmed: 34239124 ]
- Transient receptor potential cation channel subfamily v member 3 (92 kDa, Protein from Mus musculus)
- Sodium ion (22 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 3 (924 kDa, Complex from Mus musculus)
- Water (18 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 42 degrees Celsius
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 7mik
Q-score: 0.54
Nadezhdin KD, Neuberger A, Trofimov YA, Krylov NA, Sinica V, Kupko N, Vlachova V, Zakharian E, Efremov RG, Sobolevsky AI
Nat Struct Mol Biol (2021) 28 pp. 564-572 [ DOI: doi:10.1038/s41594-021-00615-4 Pubmed: 34239124 ]
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 3 (92 kDa, Protein from Mus musculus)
- Sodium ion (22 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 3 (924 kDa, Complex from Mus musculus)
Mouse TRPV3 in MSP2N2 nanodiscs, sensitized state at 42 degrees Celsius
Resolution: 3.86 Å
EM Method: Single-particle
Fitted PDBs: 7mil
Q-score: 0.408
Nadezhdin KD, Neuberger A, Trofimov YA, Krylov NA, Sinica V, Kupko N, Vlachova V, Zakharian E, Efremov RG, Sobolevsky AI
Nat Struct Mol Biol (2021) 28 pp. 564-572 [ DOI: doi:10.1038/s41594-021-00615-4 Pubmed: 34239124 ]
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 3 (92 kDa, Protein from Mus musculus)
- Sodium ion (22 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 3 (924 kDa, Complex from Mus musculus)
Mouse TRPV3 in cNW11 nanodiscs, closed state at 4 degrees Celsius
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 7mim
Q-score: 0.517
Nadezhdin KD, Neuberger A, Trofimov YA, Krylov NA, Sinica V, Kupko N, Vlachova V, Zakharian E, Efremov RG, Sobolevsky AI
Nat Struct Mol Biol (2021) 28 pp. 564-572 [ DOI: doi:10.1038/s41594-021-00615-4 Pubmed: 34239124 ]
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 3 (92 kDa, Protein from Mus musculus)
- Sodium ion (22 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 3 (924 kDa, Complex from Mus musculus)
Mouse TRPV3 in cNW11 nanodiscs, closed state at 42 degrees Celsius
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 7min
Q-score: 0.548
Nadezhdin KD, Neuberger A, Trofimov YA, Krylov NA, Sinica V, Kupko N, Vlachova V, Zakharian E, Efremov RG, Sobolevsky AI
Nat Struct Mol Biol (2021) 28 pp. 564-572 [ DOI: doi:10.1038/s41594-021-00615-4 Pubmed: 34239124 ]
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 3 (92 kDa, Protein from Mus musculus)
- Sodium ion (22 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 3 (924 kDa, Complex from Mus musculus)
Mouse TRPV3 in cNW11 nanodiscs, open state at 42 degrees Celsius
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 7mio
Q-score: 0.513
Nadezhdin KD, Neuberger A, Trofimov YA, Krylov NA, Sinica V, Kupko N, Vlachova V, Zakharian E, Efremov RG, Sobolevsky AI
Nat Struct Mol Biol (2021) 28 pp. 564-572 [ DOI: doi:10.1038/s41594-021-00615-4 Pubmed: 34239124 ]
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 3 (92 kDa, Protein from Mus musculus)
- Sodium ion (22 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 3 (924 kDa, Complex from Mus musculus)