RyR1 in detergent in close state in complex with nanobody and FKBP12
Li C, Willegems K, Uchanski T, Pardon E, Steyaert J, Efremov RG
J Biol Chem (2024) 300 pp. 107734-107734 [ Pubmed: 39233227 DOI: doi:10.1016/j.jbc.2024.107734 ]
TM part of RyR1 in detergent in close state
Li C, Willegems K, Uchanski T, Pardon E, Steyaert J, Efremov RG
J Biol Chem (2024) 300 pp. 107734-107734 [ Pubmed: 39233227 DOI: doi:10.1016/j.jbc.2024.107734 ]
Li C, Willegems K, Uchanski T, Pardon E, Steyaert J, Efremov RG
J Biol Chem (2024) 300 pp. 107734-107734 [ Pubmed: 39233227 DOI: doi:10.1016/j.jbc.2024.107734 ]
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8rrs
Q-score: 0.307
Li C, Willegems K, Uchanski T, Pardon E, Steyaert J, Efremov RG
J Biol Chem (2024) 300 pp. 107734-107734 [ Pubmed: 39233227 DOI: doi:10.1016/j.jbc.2024.107734 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Nanobody 9657 (15 kDa, Protein from Vicugna pacos)
- Ryanodine receptor 2 (565 kDa, Protein from Mus musculus)
- Mouse ryanodine receptor 2 (Complex from Mus musculus)
- Caffeine (194 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Mouse ryanodine receptor 2 complex with nanobody (Complex)
- Nanobody 9657 (Complex from Vicugna pacos)
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 8rrt
Q-score: 0.154
Li C, Willegems K, Uchanski T, Pardon E, Steyaert J, Efremov RG
J Biol Chem (2024) 300 pp. 107734-107734 [ Pubmed: 39233227 DOI: doi:10.1016/j.jbc.2024.107734 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Nanobody 9657 (15 kDa, Protein from Vicugna pacos)
- Ryanodine receptor 1 complex with fkbp12 (Complex from Oryctolagus cuniculus)
- Caffeine (194 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor1 complex with nanobody 9657 and fkbp12 (Complex)
- Ryanodine receptor 1 (564 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Oryctolagus cuniculus)
- Nanobody 9657 (Complex from Vicugna pacos)
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 8rru
Q-score: 0.11
Li C, Willegems K, Uchanski T, Pardon E, Steyaert J, Efremov RG
J Biol Chem (2024) 300 pp. 107734-107734 [ Pubmed: 39233227 DOI: doi:10.1016/j.jbc.2024.107734 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Nanobody 9657 (15 kDa, Protein from Vicugna pacos)
- Caffeine (194 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 1 (564 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Oryctolagus cuniculus)
- Ryanodine receptor 1 in complex with fkbp12 (Complex from Oryctolagus cuniculus)
- Ryanodine receptor 1 in complex with nanobody and fkbp12 (Complex)
- Nanobody 9657 (Complex from Vicugna pacos)
Structure of RyR1 in detergent in open state in complex with Ca2+, ATP, caffeine and Nb9657.
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8rrw
Q-score: 0.201
Li C, Willegems K, Uchanski T, Pardon E, Steyaert J, Efremov RG
J Biol Chem (2024) 300 pp. 107734-107734 [ Pubmed: 39233227 DOI: doi:10.1016/j.jbc.2024.107734 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Nanobody 9657 (15 kDa, Protein from Vicugna pacos)
- Ryanodine receptor 1 complex with nanobody and fkbp12 (Complex)
- Caffeine (194 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 1 (564 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Oryctolagus cuniculus)
- Ryanodine receptor 1 in complex with fkbp12 (Complex from Oryctolagus cuniculus)
- Nanobody 9657 (Complex from Vicugna pacos)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8rrx
Q-score: 0.424
Li C, Willegems K, Uchanski T, Pardon E, Steyaert J, Efremov RG
J Biol Chem (2024) 300 pp. 107734-107734 [ Pubmed: 39233227 DOI: doi:10.1016/j.jbc.2024.107734 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Nanobody 9657 (15 kDa, Protein from Vicugna pacos)
- Ryanodine receptor 1 complex with fkbp12 (Complex from Oryctolagus cuniculus)
- Ryanodine receptor 1 complex with nanobody and fkbp12 (Complex)
- Caffeine (194 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 1 (564 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Oryctolagus cuniculus)
- Nanobody 9657 (Complex from Vicugna pacos)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8rs0
Q-score: 0.356
Li C, Willegems K, Uchanski T, Pardon E, Steyaert J, Efremov RG
J Biol Chem (2024) 300 pp. 107734-107734 [ Pubmed: 39233227 DOI: doi:10.1016/j.jbc.2024.107734 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Nanobody 9657 (15 kDa, Protein from Vicugna pacos)
- Ryanodine receptor 1 complex with nanobody and fkbp12 (Complex)
- Caffeine (194 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 1 (564 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Oryctolagus cuniculus)
- Ryanodine receptor 1 in complex with fkbp12 (Complex from Oryctolagus cuniculus)
- Nanobody 9657 (Complex from Vicugna pacos)
Human TRP channel TRPV6 in cNW30 nanodiscs inhibited by tetrahydrocannabivarin (THCV)
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8sp8
Q-score: 0.515
Neuberger A, Trofimov YA, Yelshanskaya MV, Khau J, Nadezhdin KD, Khosrof LS, Krylov NA, Efremov RG, Sobolevsky AI
Nat Commun (2023) 14 pp. 4630-4630 [ DOI: doi:10.1038/s41467-023-40362-2 Pubmed: 37532722 ]
- Transient receptor potential cation channel subfamily v member 6 (76 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Sample 1 (76 kDa, Complex from Homo sapiens)
- Tetrahydrocannabivarin (286 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)