Structure of Mce1-LucB complex from Mycobacterium smegmatis (Map1)
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 8fed
Q-score: 0.524
Chen J, Fruhauf A, Fan C, Ponce J, Ueberheide B, Bhabha G, Ekiert DC
Nature (2023) 620 pp. 445-452 [ DOI: doi:10.1038/s41586-023-06366-0 Pubmed: 37495693 ]
- Virulence factor mce family protein (43 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Mce-family protein mce1f (54 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Transmembrane protein (20 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Virulence factor mce family protein (58 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Abc-transporter integral membrane protein (30 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Abc transporter, atp-binding protein,green fluorescent protein chimera (71 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Mce1 lipid transporter composed of mce1 mce proteins (mce1abcdef) and an abc transporter (yrbe1a-b, 2 copies of mceg) bound to accessory factor lucb (Complex from Mycolicibacterium smegmatis MC2 155)
- Virulence factor mce family protein (42 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Mce-family protein mce1c (54 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Virulence factor mce family protein (37 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Unknown ligand (Ligand)
- Conserved hypothetical integral membrane protein yrbe1a (27 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Structure of Mce1 transporter from Mycobacterium smegmatis in the absence of LucB (Map2)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8fee
Q-score: 0.502
Chen J, Fruhauf A, Fan C, Ponce J, Ueberheide B, Bhabha G, Ekiert DC
Nature (2023) 620 pp. 445-452 [ DOI: doi:10.1038/s41586-023-06366-0 Pubmed: 37495693 ]
- Virulence factor mce family protein (43 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Mce-family protein mce1f (54 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Mce1 lipid transporter composed of mce1 mce proteins (mce1abcdef) and an abc transporter (yrbe1a-b, 2 copies of mceg) (Complex from Mycolicibacterium smegmatis MC2 155)
- Virulence factor mce family protein (58 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Abc-transporter integral membrane protein (30 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Abc transporter, atp-binding protein,green fluorescent protein chimera (71 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Virulence factor mce family protein (42 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Mce-family protein mce1c (54 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Virulence factor mce family protein (37 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Unknown ligand (Ligand)
- Conserved hypothetical integral membrane protein yrbe1a (27 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Structure of Mce1 transporter from Mycobacterium smegmatis (Map0)
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8fef
Q-score: 0.564
Chen J, Fruhauf A, Fan C, Ponce J, Ueberheide B, Bhabha G, Ekiert DC
Nature (2023) 620 pp. 445-452 [ DOI: doi:10.1038/s41586-023-06366-0 Pubmed: 37495693 ]
- Virulence factor mce family protein (43 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Mce-family protein mce1f (54 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Mce1 lipid transporter composed of mce1 mce proteins (mce1abcdef) and an abc transporter (yrbe1a-b, 2 copies of mceg) (Complex from Mycolicibacterium smegmatis MC2 155)
- Virulence factor mce family protein (58 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Abc-transporter integral membrane protein (30 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Abc transporter, atp-binding protein,green fluorescent protein chimera (71 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Virulence factor mce family protein (42 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Mce-family protein mce1c (54 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Virulence factor mce family protein (37 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Unknown ligand (Ligand)
- Conserved hypothetical integral membrane protein yrbe1a (27 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7mi3
Q-score: 0.441
Santarossa CC, Mickolajczyk KJ, Steinman JB, Urnavicius L, Chen N, Hirata Y, Fukase Y, Coudray N, Ekiert DC, Bhabha G, Kapoor TM
Cell Chem Biol (2021) 28 pp. 1460-1473.e15 [ Pubmed: 34015309 DOI: doi:10.1016/j.chembiol.2021.04.024 ]
- Dynein motor domain in the presence of a pyrazolo-pyrimidinone-based compound (300 kDa, Complex from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Fusion protein of dynein and endolysin (304 kDa, Protein from Saccharomyces cerevisiae)
- (8s)-6-(3-bromophenoxy)-2-[1-(4-chlorophenyl)cyclopropyl]-7-hydroxypyrazolo[1,5-a]pyrimidine-3-carbonitrile (481 Da, Ligand)
Yeast dynein motor domain in the presence of a pyrazolo-pyrimidinone-based compound, Map 1
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7mi6
Q-score: 0.339
Santarossa CC, Mickolajczyk KJ, Steinman JB, Urnavicius L, Chen N, Hirata Y, Fukase Y, Coudray N, Ekiert DC, Bhabha G, Kapoor TM
Cell Chem Biol (2021) 28 pp. 1460-1473.e15 [ Pubmed: 34015309 DOI: doi:10.1016/j.chembiol.2021.04.024 ]
- Dynein motor domain in the presence of a pyrazolo-pyrimidinone-based compound (300 kDa, Complex from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Fusion protein of dynein and endolysin (304 kDa, Protein from Saccharomyces cerevisiae)
- (8s)-6-(3-bromophenoxy)-2-[1-(4-chlorophenyl)cyclopropyl]-7-hydroxypyrazolo[1,5-a]pyrimidine-3-carbonitrile (481 Da, Ligand)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7mi8
Q-score: 0.427
Santarossa CC, Mickolajczyk KJ, Steinman JB, Urnavicius L, Chen N, Hirata Y, Fukase Y, Coudray N, Ekiert DC, Bhabha G, Kapoor TM
Cell Chem Biol (2021) 28 pp. 1460-1473.e15 [ Pubmed: 34015309 DOI: doi:10.1016/j.chembiol.2021.04.024 ]
Cryo-EM structure of MlaFEDB in nanodiscs with phospholipid substrates
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 6xbd
Q-score: 0.489
Coudray N, Isom GL, MacRae MR, Saiduddin MN, Bhabha G, Ekiert DC
eLife (2020) 9 [ DOI: doi:10.7554/eLife.62518 Pubmed: 33236984 ]
- Phospholipid abc transporter-binding protein mlad (21 kDa, Protein from Escherichia coli DEC6A)
- Mlafedb complex with two bound phospholipid substrates in msp1d1 nanodisc (266 kDa, Complex from Escherichia coli K-12)
- Msp1d1 (13 kDa, Protein from Homo sapiens)
- Di-palmitoyl-3-sn-phosphatidylethanolamine (691 Da, Ligand)
- Phospholipid abc transporter permease protein mlae (27 kDa, Protein from Escherichia coli DEC6A)
- Phospholipid abc transporter-binding protein mlab (10 kDa, Protein from Escherichia coli K-12)
- Phospholipid transport system atp-binding protein mlaf (29 kDa, Protein from Escherichia coli DEC6A)
Lipophilic Envelope-spanning Tunnel B (LetB), Map 1
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 6v0c
Q-score: 0.46
Isom GL, Coudray N, MacRae MR, McManus CT, Ekiert DC, Bhabha G
Cell (2020) 181 pp. 653-664.e19 [ Pubmed: 32359438 DOI: doi:10.1016/j.cell.2020.03.030 ]
Lipophilic Envelope-spanning Tunnel B (LetB), Map 2
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 6v0d
Q-score: 0.424
Isom GL, Coudray N, MacRae MR, McManus CT, Ekiert DC, Bhabha G
Cell (2020) 181 pp. 653-664.e19 [ Pubmed: 32359438 DOI: doi:10.1016/j.cell.2020.03.030 ]
Lipophilic Envelope-spanning Tunnel B (LetB), Map 3
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 6v0e
Q-score: 0.501
Isom GL, Coudray N, MacRae MR, McManus CT, Ekiert DC, Bhabha G
Cell (2020) 181 pp. 653-664.e19 [ Pubmed: 32359438 DOI: doi:10.1016/j.cell.2020.03.030 ]