Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 6rwl
Q-score: 0.471
Cook NJ, Li W, Berta D, Badaoui M, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov P
Science (2020) 367 pp. 806-810 [ Pubmed: 32001525 DOI: doi:10.1126/science.aay4919 ]
- Dna (5'-d(p*gp*cp*tp*ap*ap*gp*ap*ap*ap*ap*ap*tp*cp*tp*cp*tp*ap*cp*cp*a)-3') (9 kDa, DNA from Simian immunodeficiency virus)
- Dna (Complex from Simian immunodeficiency virus)
- Sivrcm intasome in complex with bictegravir (Complex)
- Zinc ion (65 Da, Ligand)
- Pol protein (32 kDa, Protein from Simian immunodeficiency virus)
- Pol protein (32 kDa, Protein from Simian immunodeficiency virus)
- Dna (5'-d(*ap*ap*cp*tp*gp*gp*tp*ap*gp*ap*gp*ap*tp*tp*tp*tp*tp*cp*tp*tp*ap*gp*c)-3') (10 kDa, DNA from Simian immunodeficiency virus)
- Pol protein (32 kDa, Protein from Simian immunodeficiency virus)
- Pol protein (Complex from Simian immunodeficiency virus)
SIVrcm intasome in complex with bictegravir
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 6rwm
Q-score: 0.563
Cook NJ, Li W, Berta D, Badaoui M, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov P
Science (2020) 367 pp. 806-810 [ Pubmed: 32001525 DOI: doi:10.1126/science.aay4919 ]
- Dna (5'-d(p*gp*cp*tp*ap*ap*gp*ap*ap*ap*ap*ap*tp*cp*tp*cp*tp*ap*cp*cp*a)-3') (9 kDa, DNA from Simian immunodeficiency virus)
- Dna (Complex from Simian immunodeficiency virus)
- Sivrcm intasome in complex with bictegravir (Complex)
- Zinc ion (65 Da, Ligand)
- Water (18 Da, Ligand)
- Bictegravir (449 Da, Ligand)
- Pol protein (32 kDa, Protein from Simian immunodeficiency virus)
- Dna (5'-d(*ap*ap*cp*tp*gp*gp*tp*ap*gp*ap*gp*ap*tp*tp*tp*tp*tp*cp*tp*tp*ap*gp*c)-3') (10 kDa, DNA from Simian immunodeficiency virus)
- Magnesium ion (24 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Pol protein (Complex from Simian immunodeficiency virus)
SIVrcm intasome in complex with dolutegravir
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6rwn
Q-score: 0.524
Cook NJ, Li W, Berta D, Badaoui M, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov P
Science (2020) 367 pp. 806-810 [ Pubmed: 32001525 DOI: doi:10.1126/science.aay4919 ]
- (4r,12as)-n-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2h-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide (419 Da, Ligand)
- Dna (5'-d(p*gp*cp*tp*ap*ap*gp*ap*ap*ap*ap*ap*tp*cp*tp*cp*tp*ap*cp*cp*a)-3') (9 kDa, DNA from Simian immunodeficiency virus)
- Dna (Complex from Simian immunodeficiency virus)
- Zinc ion (65 Da, Ligand)
- Pol protein (32 kDa, Protein from Simian immunodeficiency virus)
- Dna (5'-d(*ap*ap*cp*tp*gp*gp*tp*ap*gp*ap*gp*ap*tp*tp*tp*tp*tp*cp*tp*tp*ap*gp*c)-3') (10 kDa, DNA from Simian immunodeficiency virus)
- Magnesium ion (24 Da, Ligand)
- Pol protein (Complex from Simian immunodeficiency virus)
- Sivrcm intasome in complex with dolutegravir (Complex)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
SIVrcm intasome (Q148H/G140S) in complex with bictegravir
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 6rwo
Q-score: 0.538
Cook NJ, Li W, Berta D, Badaoui M, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov P
Science (2020) 367 pp. 806-810 [ Pubmed: 32001525 DOI: doi:10.1126/science.aay4919 ]
- Dna (5'-d(p*gp*cp*tp*ap*ap*gp*ap*ap*ap*ap*ap*tp*cp*tp*cp*tp*ap*cp*cp*a)-3') (9 kDa, DNA from Simian immunodeficiency virus)
- Dna (Complex from Simian immunodeficiency virus)
- Sivrcm intasome in complex with bictegravir (Complex)
- Pol protein (32 kDa, Protein from Simian immunodeficiency virus)
- Zinc ion (65 Da, Ligand)
- Bictegravir (449 Da, Ligand)
- Water (18 Da, Ligand)
- Dna (5'-d(*ap*ap*cp*tp*gp*gp*tp*ap*gp*ap*gp*ap*tp*tp*tp*tp*tp*cp*tp*tp*ap*gp*c)-3') (10 kDa, DNA from Simian immunodeficiency virus)
- Magnesium ion (24 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Pol protein (Complex from Simian immunodeficiency virus)
Three-dimensional structure of the full MMTV intasome
Ballandras-Colas A, Brown M, Cook NJ, Dewdney TG, Demeler B, Cherepanov P, Lyumkis D, Engelman AN
Nature (2016) 530 pp. 358-361 [ Pubmed: 26887496 DOI: doi:10.1038/nature16955 ]
- Mouse mammary tumor virus intasome complex (318 MDa, Sample)
- Mmtv u5 dna end (13 kDa, DNA from Mouse mammary tumor virus)
- Betaretroviral integrase (36 kDa, Protein from Mouse mammary tumor virus)
Three-dimensional structure of the core MMTV intasome
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 3jca
Q-score: 0.245
Ballandras-Colas A, Brown M, Cook NJ, Dewdney TG, Demeler B, Cherepanov P, Lyumkis D, Engelman AN
Nature (2016) 530 pp. 358-361 [ Pubmed: 26887496 DOI: doi:10.1038/nature16955 ]
- Mouse mammary tumor virus intasome complex (194 MDa, Sample)
- Mmtv u5 dna end (13 kDa, DNA from Mouse mammary tumor virus)
- Betaretroviral integrase (36 kDa, Protein from Mouse mammary tumor virus)