MVV cleaved synaptic complex (CSC) intasome at 4.5 A resolution (re-refined)
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7zpp
Q-score: 0.097
Ballandras-Colas A, Maskell DP, Serrao E, Locke J, Swuec P, Jonsson SR, Kotecha A, Cook NJ, Pye VE, Taylor IA, Andresdottir V, Engelman AN, Costa A, Cherepanov P
Science (2017) 355 pp. 93-95 [ Pubmed: 28059770 DOI: doi:10.1126/science.aah7002 ]
- Intergrase (Complex from Visna/maedi virus EV1 KV1772)
- Vdna, non-transferred strand (6 kDa, DNA from Visna lentivirus (strain 1514))
- Vdna, transferred strand (5 kDa, DNA from Visna-maedi virus)
- Maedi-visna virus (mvv) intasome (542 kDa, Complex)
- Vdna (Complex from Visna-maedi virus)
- Integrase (32 kDa, Protein from Visna/maedi virus EV1 KV1772)
Helical reconstruction of HIV capsid protein
Bester SM, Wei G, Zhao H, Adu-Ampratwum D, Iqbal N, Courouble VV, Francis AC, Annamalai AS, Singh PK, Shkriabai N, Van Blerkom P, Morrison J, Poeschla EM, Engelman AN, Melikyan GB, Griffin PR, Fuchs JR, Asturias FJ, Kvaratskhelia M
Science (2020) 370 pp. 360-364 [ DOI: doi:10.1126/science.abb4808 Pubmed: 33060363 ]
Hexamer of Helical HIV capsid by RASTR method
Resolution: 6.08 Å
EM Method: Helical reconstruction
Fitted PDBs: 6vws
Q-score: 0.188
Bester SM, Wei G, Zhao H, Adu-Ampratwum D, Iqbal N, Courouble VV, Francis AC, Annamalai AS, Singh PK, Shkriabai N, Van Blerkom P, Morrison J, Poeschla EM, Engelman AN, Melikyan GB, Griffin PR, Fuchs JR, Asturias FJ, Kvaratskhelia M
Science (2020) 370 pp. 360-364 [ DOI: doi:10.1126/science.abb4808 Pubmed: 33060363 ]
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 6rwl
Q-score: 0.471
Cook NJ, Li W, Berta D, Badaoui M, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov P
Science (2020) 367 pp. 806-810 [ Pubmed: 32001525 DOI: doi:10.1126/science.aay4919 ]
- Sivrcm intasome in complex with bictegravir (Complex)
- Dna (5'-d(p*gp*cp*tp*ap*ap*gp*ap*ap*ap*ap*ap*tp*cp*tp*cp*tp*ap*cp*cp*a)-3') (9 kDa, DNA from Simian immunodeficiency virus)
- Pol protein (32 kDa, Protein from Simian immunodeficiency virus)
- Pol protein (32 kDa, Protein from Simian immunodeficiency virus)
- Zinc ion (65 Da, Ligand)
- Dna (5'-d(*ap*ap*cp*tp*gp*gp*tp*ap*gp*ap*gp*ap*tp*tp*tp*tp*tp*cp*tp*tp*ap*gp*c)-3') (10 kDa, DNA from Simian immunodeficiency virus)
- Pol protein (32 kDa, Protein from Simian immunodeficiency virus)
- Pol protein (Complex from Simian immunodeficiency virus)
- Dna (Complex from Simian immunodeficiency virus)
SIVrcm intasome in complex with bictegravir
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 6rwm
Q-score: 0.563
Cook NJ, Li W, Berta D, Badaoui M, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov P
Science (2020) 367 pp. 806-810 [ Pubmed: 32001525 DOI: doi:10.1126/science.aay4919 ]
- Sivrcm intasome in complex with bictegravir (Complex)
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Dna (5'-d(p*gp*cp*tp*ap*ap*gp*ap*ap*ap*ap*ap*tp*cp*tp*cp*tp*ap*cp*cp*a)-3') (9 kDa, DNA from Simian immunodeficiency virus)
- Pol protein (32 kDa, Protein from Simian immunodeficiency virus)
- Zinc ion (65 Da, Ligand)
- Bictegravir (449 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Dna (5'-d(*ap*ap*cp*tp*gp*gp*tp*ap*gp*ap*gp*ap*tp*tp*tp*tp*tp*cp*tp*tp*ap*gp*c)-3') (10 kDa, DNA from Simian immunodeficiency virus)
- Pol protein (Complex from Simian immunodeficiency virus)
- Dna (Complex from Simian immunodeficiency virus)
SIVrcm intasome in complex with dolutegravir
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6rwn
Q-score: 0.524
Cook NJ, Li W, Berta D, Badaoui M, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov P
Science (2020) 367 pp. 806-810 [ Pubmed: 32001525 DOI: doi:10.1126/science.aay4919 ]
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- (4r,12as)-n-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2h-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide (419 Da, Ligand)
- Dna (5'-d(p*gp*cp*tp*ap*ap*gp*ap*ap*ap*ap*ap*tp*cp*tp*cp*tp*ap*cp*cp*a)-3') (9 kDa, DNA from Simian immunodeficiency virus)
- Pol protein (32 kDa, Protein from Simian immunodeficiency virus)
- Zinc ion (65 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Dna (5'-d(*ap*ap*cp*tp*gp*gp*tp*ap*gp*ap*gp*ap*tp*tp*tp*tp*tp*cp*tp*tp*ap*gp*c)-3') (10 kDa, DNA from Simian immunodeficiency virus)
- Dna (Complex from Simian immunodeficiency virus)
- Sivrcm intasome in complex with dolutegravir (Complex)
- Pol protein (Complex from Simian immunodeficiency virus)
SIVrcm intasome (Q148H/G140S) in complex with bictegravir
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 6rwo
Q-score: 0.538
Cook NJ, Li W, Berta D, Badaoui M, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov P
Science (2020) 367 pp. 806-810 [ Pubmed: 32001525 DOI: doi:10.1126/science.aay4919 ]
- Sivrcm intasome in complex with bictegravir (Complex)
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Dna (5'-d(p*gp*cp*tp*ap*ap*gp*ap*ap*ap*ap*ap*tp*cp*tp*cp*tp*ap*cp*cp*a)-3') (9 kDa, DNA from Simian immunodeficiency virus)
- Zinc ion (65 Da, Ligand)
- Bictegravir (449 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Dna (5'-d(*ap*ap*cp*tp*gp*gp*tp*ap*gp*ap*gp*ap*tp*tp*tp*tp*tp*cp*tp*tp*ap*gp*c)-3') (10 kDa, DNA from Simian immunodeficiency virus)
- Pol protein (Complex from Simian immunodeficiency virus)
- Pol protein (32 kDa, Protein from Simian immunodeficiency virus)
- Dna (Complex from Simian immunodeficiency virus)
Cryo-EM reconstruction of the maedi-visna virus (MVV) strand transfer complex
Resolution: 8.2 Å
EM Method: Single-particle
Fitted PDBs: 5m0r
Q-score: 0.098
Ballandras-Colas A, Maskell DP, Serrao E, Locke J, Swuec P, Jonsson SR, Kotecha A, Cook NJ, Pye VE, Taylor IA, Andresdottir V, Engelman AN, Costa A, Cherepanov P
Science (2017) 355 pp. 93-95 [ Pubmed: 28059770 DOI: doi:10.1126/science.aah7002 ]
- Nucleic acid (Complex from synthetic construct)
- Integrase (32 kDa, Protein from Maedi visna virus (strain KV1772))
- Intergrase (Complex from Maedi visna virus (strain KV1772))
- Vdna-tdna, transferred strand, joined to a model tdna (15 kDa, DNA from Visna lentivirus (strain 1514))
- Mvv strand transfer complex (Complex)
- Vdna, non-transfered strand (6 kDa, DNA from Visna lentivirus (strain 1514))
- Nucleic acid (Complex from Visna lentivirus (strain 1514))
- Tdna (7 kDa, DNA from synthetic construct)