Cryo-EM structure of POLRMT mutant.
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7zc4
Q-score: 0.328
Zhu X, Xie X, Das H, Tan BG, Shi Y, Al-Behadili A, Peter B, Motori E, Valenzuela S, Posse V, Gustafsson CM, Hallberg BM, Falkenberg M
Cell (2022) 185 pp. 2309-2323.e24 [ Pubmed: 35662414 DOI: doi:10.1016/j.cell.2022.05.006 ]
- Polrmt (137 kDa, Cellular component from Homo sapiens)
- Dna-directed rna polymerase, mitochondrial (134 kDa, Protein from Homo sapiens)
Cryo-EM structure of POLRMT in free form.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7pzr
Q-score: 0.385
Zhu X, Xie X, Das H, Tan BG, Shi Y, Al-Behadili A, Peter B, Motori E, Valenzuela S, Posse V, Gustafsson CM, Hallberg BM, Falkenberg M
Cell (2022) 185 pp. 2309-2323.e24 [ Pubmed: 35662414 DOI: doi:10.1016/j.cell.2022.05.006 ]
- Dna-directed rna polymerase, mitochondrial (137 kDa, Protein from Homo sapiens)
- Polrmt (137 kDa, Complex from Homo sapiens)
Zhu X, Xie X, Das H, Tan BG, Shi Y, Al-Behadili A, Peter B, Motori E, Valenzuela S, Posse V, Gustafsson CM, Hallberg BM, Falkenberg M
Cell (2022) 185 pp. 2309-2323.e24 [ Pubmed: 35662414 DOI: doi:10.1016/j.cell.2022.05.006 ]
Mitochondrial DNA dependent RNA polymerase homodimer.
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7pzp
Q-score: 0.323
Zhu X, Xie X, Das H, Tan BG, Shi Y, Al-Behadili A, Peter B, Motori E, Valenzuela S, Posse V, Gustafsson CM, Hallberg BM, Falkenberg M
Cell (2022) 185 pp. 2309- [ Pubmed: 35662414 DOI: doi:10.1016/j.cell.2022.05.006 ]
- Mitochondrial dna-directed rna polymerase dimer. (Complex from Homo sapiens)
- Dna-directed rna polymerase, mitochondrial (137 kDa, Protein from Homo sapiens)
- Polrmt (137 kDa, Complex)
Human mitochondrial Lon protease with substrate in the ATPase domain
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7p09
Q-score: 0.534
Valentin Gese G, Shahzad S, Pardo-Hernandez C, Wramstedt A, Falkenberg M, Hallberg M
To Be Published
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Composite map of human mitochondrial lonp1 (591 kDa, Complex from Homo sapiens)
- Lon protease homolog, mitochondrial (98 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Unknown peptide from human mitochondrial transcription factor a (tfam) (954 Da, Protein from Homo sapiens)
Human mitochondrial Lon protease without substrate
Resolution: 4.11 Å
EM Method: Single-particle
Fitted PDBs: 7p0b
Q-score: 0.295
Valentin Gese G, Shahzad S, Pardo-Hernandez C, Wramstedt A, Falkenberg M, Hallberg M
To Be Published
- Human mitochondrial lonp1 g106p, r563w and k594m mutant (591 kDa, Complex from Homo sapiens)
- Lon protease homolog, mitochondrial (98 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Human mitochondrial Lon protease with substrate in the ATPase and protease domains
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 7p0m
Q-score: 0.522
Valentin Gese G, Shahzad S, Pardo-Hernandez C, Wramstedt A, Falkenberg M, Hallberg M
To Be Published
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Human mitochondrial lonp1 k898a mutant (591 kDa, Complex from Homo sapiens)
- Lon protease homolog, mitochondrial (99 kDa, Protein from Homo sapiens)
- Unknown peptide from human mitochondrial transcription factor a (tfam) (954 Da, Protein from Homo sapiens)
Structure of human mitochondrial RNA polymerase in complex with IMT inhibitor.
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7a8p
Q-score: 0.463
Bonekamp NA, Peter B, Hillen HS, Felser A, Bergbrede T, Choidas A, Horn M, Unger A, Di Lucrezia R, Atanassov I, Li X, Koch U, Menninger S, Boros J, Habenberger P, Giavalisco P, Cramer P, Denzel MS, Nussbaumer P, Klebl B, Falkenberg M, Gustafsson CM, Larsson NG
Nature (2020) 588 pp. 712-716 [ Pubmed: 33328633 DOI: doi:10.1038/s41586-020-03048-z ]
- Human polrmt (lacking residues 1-104) in complex with imt inhibitor. (128 kDa, Complex from Homo sapiens)
- (3~{r})-1-[(2~{r})-2-[4-(2-chloranyl-4-fluoranyl-phenyl)-2-oxidanylidene-chromen-7-yl]oxypropanoyl]piperidine-3-carboxylic acid (473 Da, Ligand)
- Dna-directed rna polymerase, mitochondrial (129 kDa, Protein from Homo sapiens)