Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8v7z
Q-score: 0.496
Gao X, Yeh HI, Yang Z, Fan C, Jiang F, Howard RJ, Lindahl E, Kappes JC, Hwang TC
Nat Commun (2024) 15 pp. 6668-6668 [ DOI: doi:10.1038/s41467-024-50641-1 Pubmed: 39107303 ]
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (161 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- E1371q-cftr (Complex from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8v81
Q-score: 0.507
Gao X, Yeh HI, Yang Z, Fan C, Jiang F, Howard RJ, Lindahl E, Kappes JC, Hwang TC
Nat Commun (2024) 15 pp. 6668-6668 [ DOI: doi:10.1038/s41467-024-50641-1 Pubmed: 39107303 ]
- 4-[(z)-{(3m)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid (409 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (163 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- E1371q-cftr (Complex from Homo sapiens)
Structure of HIV-1 BG505 SOSIP-HT1 in complex with one CD4 molecule
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8fyi
Q-score: 0.493
Dam KA, Fan C, Yang Z, Bjorkman PJ
Nature (2023) 623 pp. 1017-1025 [ DOI: doi:10.1038/s41586-023-06639-8 Pubmed: 37993719 ]
- Envelope glycoprotein gp160 (53 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (14 kDa, Protein from Human immunodeficiency virus 1)
- T-cell surface glycoprotein cd4 (42 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp160 (53 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 env trimer bg505 sosip.664 in complex with one cd4 molecule (Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of HIV-1 BG505 SOSIP-HT2 in complex with two CD4 molecules (class I)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8fyj
Q-score: 0.357
Dam KA, Fan C, Yang Z, Bjorkman PJ
Nature (2023) 623 pp. 1017-1025 [ DOI: doi:10.1038/s41586-023-06639-8 Pubmed: 37993719 ]
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp160 (53 kDa, Protein from Human immunodeficiency virus 1)
- T-cell surface glycoprotein cd4 (42 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp160 (53 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 env trimer bg505 sosip.664 in complex with two cd4 molecules (Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 spike glycoprotein trimer in closed state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7wgv
Q-score: 0.513
Zhao MM, Zhu Y, Zhang L, Zhong G, Tai L, Liu S, Yin G, Lu J, He Q, Li MJ, Zhao RX, Wang H, Huang W, Fan C, Shuai L, Wen Z, Wang C, He X, Chen Q, Liu B, Xiong X, Bu Z, Wang Y, Sun F, Yang JK
Cell Discov (2022) 8 pp. 53- [ DOI: doi:10.1038/s41421-022-00419-w ]
- 3-[5-[(z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(z)-(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1h-pyrrol-2-yl]methyl]-4-methyl-1h-pyrrol-3-yl]propanoic acid (584 Da, Ligand)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 b.1.1.7 spike glycoprotein trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- Linoleic acid (280 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 spike glycoprotein trimer in closed state after treatment with Cathepsin L
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7wgx
Q-score: 0.468
Zhao MM, Zhu Y, Zhang L, Zhong G, Tai L, Liu S, Yin G, Lu J, He Q, Li MJ, Zhao RX, Wang H, Huang W, Fan C, Shuai L, Wen Z, Wang C, He X, Chen Q, Liu B, Xiong X, Bu Z, Wang Y, Sun F, Yang JK
Cell Discov (2022) 8 pp. 53- [ DOI: doi:10.1038/s41421-022-00419-w ]
- 3-[5-[(z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(z)-(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1h-pyrrol-2-yl]methyl]-4-methyl-1h-pyrrol-3-yl]propanoic acid (584 Da, Ligand)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 b.1.1.7 spike glycoprotein trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 spike glycoprotein trimer in Intermediate state
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7wgy
Q-score: 0.354
SARS-CoV-2 spike glycoprotein trimer in open state
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7wgz
Q-score: 0.297