Electron Microscopy Data Bank

Download Map 3D View Raw data

Phosphorylated, ATP-bound, E1371Q human cystic fibrosis transmembrane conductance regulator (E1371Q-CFTR)

Release date: July 17, 2024
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8v7z
Q-score: 0.496

Gao X, Yeh HI, Yang Z, Fan C, Jiang F, Howard RJ, Lindahl E, Kappes JC, Hwang TC

Nat Commun (2024) 15 pp. 6668-6668 [ Pubmed: 39107303 DOI: doi:10.1038/s41467-024-50641-1 ]

Sample:

E1371q-cftr (Complex from Homo sapiens)
Cystic fibrosis transmembrane conductance regulator (161 kDa, Protein from Homo sapiens)
Adenosine-5'-triphosphate (507 Da, Ligand)
Magnesium ion (24 Da, Ligand)
Cholesterol (386 Da, Ligand)
(2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)

[Show more]

EMD-43014

Download Map 3D View Raw data

Phosphorylated, ATP-bound, inhibitor 172-bound E1371Q human cystic fibrosis transmembrane conductance regulator

Release date: July 17, 2024
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8v81
Q-score: 0.507

Gao X, Yeh HI, Yang Z, Fan C, Jiang F, Howard RJ, Lindahl E, Kappes JC, Hwang TC

Nat Commun (2024) 15 pp. 6668-6668 [ Pubmed: 39107303 DOI: doi:10.1038/s41467-024-50641-1 ]

Sample:

E1371q-cftr (Complex from Homo sapiens)
4-[(z)-{(3m)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid (409 Da, Ligand)
Cystic fibrosis transmembrane conductance regulator (163 kDa, Protein from Homo sapiens)
Adenosine-5'-triphosphate (507 Da, Ligand)
Magnesium ion (24 Da, Ligand)
Cholesterol (386 Da, Ligand)
(2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)

[Show more]

EMD-29023

Download Map 3D View Raw data

Structure of Mce1-LucB complex from Mycobacterium smegmatis (Map1)

Release date: Feb. 22, 2023
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 8fed
Q-score: 0.524

Chen J, Fruhauf A, Fan C, Ponce J, Ueberheide B, Bhabha G, Ekiert DC

Nature (2023) 620 pp. 445-452 [ Pubmed: 37495693 DOI: doi:10.1038/s41586-023-06366-0 ]

Sample:

Abc-transporter integral membrane protein (30 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Virulence factor mce family protein (58 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Virulence factor mce family protein (37 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Virulence factor mce family protein (42 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Conserved hypothetical integral membrane protein yrbe1a (27 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Mce-family protein mce1f (54 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Virulence factor mce family protein (43 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Unknown ligand (Ligand)
Mce-family protein mce1c (54 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Transmembrane protein (20 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Abc transporter, atp-binding protein,green fluorescent protein chimera (71 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Mce1 lipid transporter composed of mce1 mce proteins (mce1abcdef) and an abc transporter (yrbe1a-b, 2 copies of mceg) bound to accessory factor lucb (Complex from Mycolicibacterium smegmatis MC2 155)

[Show more]

EMD-29024

Download Map 3D View Raw data

Structure of Mce1 transporter from Mycobacterium smegmatis in the absence of LucB (Map2)

Release date: Feb. 22, 2023
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8fee
Q-score: 0.502

Chen J, Fruhauf A, Fan C, Ponce J, Ueberheide B, Bhabha G, Ekiert DC

Nature (2023) 620 pp. 445-452 [ Pubmed: 37495693 DOI: doi:10.1038/s41586-023-06366-0 ]

Sample:

Abc-transporter integral membrane protein (30 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Virulence factor mce family protein (58 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Virulence factor mce family protein (37 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Virulence factor mce family protein (42 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Conserved hypothetical integral membrane protein yrbe1a (27 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Mce1 lipid transporter composed of mce1 mce proteins (mce1abcdef) and an abc transporter (yrbe1a-b, 2 copies of mceg) (Complex from Mycolicibacterium smegmatis MC2 155)
Mce-family protein mce1f (54 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Virulence factor mce family protein (43 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Unknown ligand (Ligand)
Mce-family protein mce1c (54 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Abc transporter, atp-binding protein,green fluorescent protein chimera (71 kDa, Protein from Mycolicibacterium smegmatis MC2 155)

[Show more]

EMD-29025

Download Map 3D View Raw data

Structure of Mce1 transporter from Mycobacterium smegmatis (Map0)

Release date: Feb. 22, 2023
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8fef
Q-score: 0.564

Chen J, Fruhauf A, Fan C, Ponce J, Ueberheide B, Bhabha G, Ekiert DC

Nature (2023) 620 pp. 445-452 [ Pubmed: 37495693 DOI: doi:10.1038/s41586-023-06366-0 ]

Sample:

Abc-transporter integral membrane protein (30 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Virulence factor mce family protein (58 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Virulence factor mce family protein (37 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Virulence factor mce family protein (42 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Conserved hypothetical integral membrane protein yrbe1a (27 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Mce1 lipid transporter composed of mce1 mce proteins (mce1abcdef) and an abc transporter (yrbe1a-b, 2 copies of mceg) (Complex from Mycolicibacterium smegmatis MC2 155)
Mce-family protein mce1f (54 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Virulence factor mce family protein (43 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Unknown ligand (Ligand)
Mce-family protein mce1c (54 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Abc transporter, atp-binding protein,green fluorescent protein chimera (71 kDa, Protein from Mycolicibacterium smegmatis MC2 155)

[Show more]

EMD-29228

Download Map 3D View Raw data

Local refinement of MceG in Msmeg Mce1 transporter (Map0a)

Release date: Feb. 15, 2023
Resolution: 2.91 Å
EM Method: Single-particle

Chen J, Fruhauf A, Fan C, Ponce J, Ueberheide B, Bhabha G, Ekiert DC

Nature (2023) 620 pp. 445-452 [ Pubmed: 37495693 DOI: doi:10.1038/s41586-023-06366-0 ]

Sample:

[Show more]

EMD-29229

Download Map 3D View Raw data

Local refinement of YrbE and MCE ring in Msmeg Mce1 transporter (Map0b)

Release date: Feb. 15, 2023
Resolution: 2.73 Å
EM Method: Single-particle

Chen J, Fruhauf A, Fan C, Ponce J, Ueberheide B, Bhabha G, Ekiert DC

Nature (2023) 620 pp. 445-452 [ Pubmed: 37495693 DOI: doi:10.1038/s41586-023-06366-0 ]

Sample:

[Show more]

EMD-29230

Download Map 3D View Raw data

Local refinement of MCE ring and needle in Msmeg Mce1 transporter (Map0c)

Release date: Feb. 15, 2023
Resolution: 2.75 Å
EM Method: Single-particle

Chen J, Fruhauf A, Fan C, Ponce J, Ueberheide B, Bhabha G, Ekiert DC

Nature (2023) 620 pp. 445-452 [ Pubmed: 37495693 DOI: doi:10.1038/s41586-023-06366-0 ]

Sample:

[Show more]

EMD-29231

Download Map 3D View Raw data

Local refinement of MCE needle and portal in Msmeg Mce1 transporter (Map0d)

Release date: Feb. 15, 2023
Resolution: 3.0 Å
EM Method: Single-particle

Chen J, Fruhauf A, Fan C, Ponce J, Ueberheide B, Bhabha G, Ekiert DC

Nature (2023) 620 pp. 445-452 [ Pubmed: 37495693 DOI: doi:10.1038/s41586-023-06366-0 ]

Sample:

[Show more]

EMD-29232

Download Map 3D View Raw data

Raw, consensus refinement of Msmeg Mce1 transporter (Map0e)

Release date: Feb. 15, 2023
Resolution: 2.92 Å
EM Method: Single-particle

Chen J, Fruhauf A, Fan C, Ponce J, Ueberheide B, Bhabha G, Ekiert DC

Nature (2023) 620 pp. 445-452 [ Pubmed: 37495693 DOI: doi:10.1038/s41586-023-06366-0 ]

Sample:

[Show more]

Filter By

Filter By

Filter By

Number of entries released by year

Download

Download

Filter By