Cryo-EM structure of LY341495/NAM-bound mGlu3
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 7wi6
Q-score: 0.43
Fang W, Yang F, Xu C, Ling S, Lin L, Zhou Y, Sun W, Wang X, Liu P, Rondard P, Shi P, Pin JP, Tian C, Liu J
Cell Res (2022) 32 pp. 695-698 [ Pubmed: 35236939 DOI: doi:10.1038/s41422-022-00623-z ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2-[(1s,2s)-2-carboxycyclopropyl]-3-(9h-xanthen-9-yl)-d-alanine (353 Da, Ligand)
- Cryo-em structure of mglu3 bound with ly2794193 (Complex from Homo sapiens)
- Metabotropic glutamate receptor 3 (100 kDa, Protein from Homo sapiens)
Cryo-EM structure of inactive mGlu3 bound to LY341495
Resolution: 4.17 Å
EM Method: Single-particle
Fitted PDBs: 7wi8
Q-score: 0.394
Fang W, Yang F, Xu C, Ling S, Lin L, Zhou Y, Sun W, Wang X, Liu P, Rondard P, Shi P, Pin JP, Tian C, Liu J
Cell Res (2022) 32 pp. 695-698 [ DOI: doi:10.1038/s41422-022-00623-z Pubmed: 35236939 ]
- Metabotropic glutamate receptor 3 (100 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2-[(1s,2s)-2-carboxycyclopropyl]-3-(9h-xanthen-9-yl)-d-alanine (353 Da, Ligand)
- Cryo-em structure of mglu3 bound with ly2794193 (Complex from Homo sapiens)
Cryo-EM structure of LY2794193-bound mGlu3
Resolution: 3.68 Å
EM Method: Single-particle
Fitted PDBs: 7wih
Q-score: 0.421
Fang W, Yang F, Xu C, Ling S, Lin L, Zhou Y, Sun W, Wang X, Liu P, Rondard P, Shi P, Pin JP, Tian C, Liu J
Cell Res (2022) 32 pp. 695-698 [ DOI: doi:10.1038/s41422-022-00623-z Pubmed: 35236939 ]
- Metabotropic glutamate receptor 3 (100 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (1s,2s,4s,5r,6s)-2-amino-4-[(3-methoxybenzene-1-carbonyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid (334 Da, Ligand)
- Cryo-em structure of mglu3 bound with ly2794193 (Complex from Homo sapiens)
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 7dhi
Q-score: 0.531
Yang F, Ling SL, Zhou YX, Zhang YN, Lv P, Liu SL, Fang W, Sun WJ, Hu LYA, Zhang L, Shi P, Tian C
Natl Sci Rev (2020) [ DOI: doi:10.1093/nsr/nwaa284 ]
- Nb35 nanobody (17 kDa, Protein from Lama glama)
- Water (18 Da, Ligand)
- Salbutamol (239 Da, Ligand)
- Cryo-em structure of the partial agonist salbutamol-bound beta2 adrenergic receptor-gs protein complex. (151 MDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Beta-2 adrenergic receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Bos taurus)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7dhr
Q-score: 0.472
Yang F, Ling SL, Zhou YX, Zhang YN, Lv P, Liu SL, Fang W, Sun WJ, Hu LYA, Zhang L, Shi P, Tian C
Natl Sci Rev (2020) [ DOI: doi:10.1093/nsr/nwaa284 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Bos taurus)
- Beta-2 adrenergic receptor (42 kDa, Protein from Homo sapiens)
- Cryo-em structure of the full agonist isoprenaline-bound beta2 adrenergic receptor-gs protein complex. (151 MDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nb35 nanobody (17 kDa, Protein from Lama glama)
- Isoprenaline (211 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
Cryo-EM structure of the formoterol-bound beta2 adrenergic receptor-Gs protein complex.
Resolution: 3.82 Å
EM Method: Single-particle
Fitted PDBs: 7bz2
Q-score: 0.477
Zhang Y, Yang F, Ling S, Lv P, Zhou Y, Fang W, Sun W, Zhang L, Shi P, Tian C
Cell Discov (2020) 6 pp. 45-45 [ Pubmed: 32655881 DOI: doi:10.1038/s41421-020-0176-9 ]
- Nb35 nanobody (17 kDa, Protein from Lama glama)
- Beta2 adrenergic receptor-gs trimer complex with formoterol (151 MDa, Complex from Homo sapiens)
- ~{n}-[5-[(1~{r})-2-[[(2~{r})-1-(4-methoxyphenyl)propan-2-yl]amino]-1-oxidanyl-ethyl]-2-oxidanyl-phenyl]methanamide (344 Da, Ligand)
- Beta2 adrenergic receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Bos taurus)