Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with primidone
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 9b28
Q-score: 0.438
Yin Y, Park CG, Feng S, Guan Z, Lee HJ, Zhang F, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01463-8 Pubmed: 39809942 ]
- Primidone (218 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential cation channel, subfamily m, member 3 (198 kDa, Protein from Mus musculus)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 3 (Complex from Mus musculus)
Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with cholesteryl hemisuccinate
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 9b29
Q-score: 0.394
Yin Y, Park CG, Feng S, Guan Z, Lee HJ, Zhang F, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01463-8 Pubmed: 39809942 ]
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential cation channel, subfamily m, member 3 (198 kDa, Protein from Mus musculus)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 3 (Complex from Mus musculus)
Resolution: 3.82 Å
EM Method: Single-particle
Fitted PDBs: 9b2a
Q-score: 0.34
Yin Y, Park CG, Feng S, Guan Z, Lee HJ, Zhang F, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01463-8 Pubmed: 39809942 ]
- Pregnenolone sulfate (396 Da, Ligand)
- Transient receptor potential cation channel, subfamily m, member 3 (198 kDa, Protein from Mus musculus)
- (2s)-2-(3,4-dihydroquinolin-1(2h)-yl)-n-(5-methyl-1,2-oxazol-3-yl)-2-phenylacetamide (347 Da, Ligand)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 3 (Complex from Mus musculus)
Resolution: 2.11 Å
EM Method: Single-particle
Fitted PDBs: 8z8z
Q-score: 0.589
Xiong Q, Zhu Z, Li T, Li X, Zhou Z, Chao Y, Yang C, Feng S, Qu Q, Li D
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01474-5 Pubmed: 39824977 ]
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (4~{z},7~{z},10~{z},13~{z},16~{z},19~{z})-docosa-4,7,10,13,16,19-hexaenoate (764 Da, Ligand)
- Lychos (127 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lysosomal cholesterol signaling protein,fluorescent protein (127 kDa, Protein from synthetic construct)
Scalable protein design using hallucination in a relaxed sequence space
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 9exk
Q-score: 0.422
Frank C, Khoshouei A, Fu beta L, Schiwietz D, Putz D, Weber L, Zhao Z, Hattori M, Feng S, de Stigter Y, Ovchinnikov S, Dietz H
Science (2024) 386 pp. 439-445 [ DOI: doi:10.1126/science.adq1741 Pubmed: 39446959 ]
- De novo designed protein k12 (115 kDa, Protein from synthetic construct)
- De novo designed protein k12 (114 kDa, Cellular component from synthetic construct)
Scalable protein design using hallucination in a relaxed sequence space
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 9f0l
Q-score: 0.52
Frank C, Khoshouei A, Fu beta L, Schiwietz D, Putz D, Weber L, Zhao Z, Hattori M, Feng S, de Stigter Y, Ovchinnikov S, Dietz H
Science (2024) 386 pp. 439-445 [ DOI: doi:10.1126/science.adq1741 Pubmed: 39446959 ]
- De novo designed protein k10 (106 kDa, Protein from synthetic construct)
- De novo designed protein k10 (106 kDa, Cellular component from synthetic construct)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8xqw
Q-score: 0.502
Liang K, Zhan X, Li Y, Yang Y, Xie Y, Jin Z, Xu X, Zhang W, Lu Y, Zhang S, Zou Y, Feng S, Wu J, Yan Z
Cell (2024) 187 pp. 5638-5650.e18 [ DOI: doi:10.1016/j.cell.2024.08.002 Pubmed: 39197449 ]
- Ctap7 (71 kDa, Protein from Chlamydomonas reinhardtii)
- Ctap1 (107 kDa, Protein from Chlamydomonas reinhardtii)
- Fhl3 (120 kDa, Protein from Chlamydomonas reinhardtii)
- Crtam29 (29 kDa, Protein from Chlamydomonas reinhardtii)
- 1,2-di-o-acyl-3-o-[6-deoxy-6-sulfo-alpha-d-glucopyranosyl]-sn-glycerol (795 Da, Ligand)
- 1,2-distearoyl-monogalactosyl-diglyceride (787 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Pcya (61 kDa, Protein from Chlamydomonas reinhardtii)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Beta-sitosterol (416 Da, Ligand)
- Ycf2 (342 kDa, Protein from Chlamydomonas reinhardtii)
- Fhl1 (128 kDa, Protein from Chlamydomonas reinhardtii)
- Unk (7 kDa, Protein from Chlamydomonas reinhardtii)
- Dnaj (50 kDa, Protein from Chlamydomonas reinhardtii)
- Ctap6 (109 kDa, Protein from Chlamydomonas reinhardtii)
- Tic22 (40 kDa, Protein from Chlamydomonas reinhardtii)
- The ycf2-ftshi motor complex from chlamydomonas (Complex from Chlamydomonas reinhardtii)
- Acp (12 kDa, Protein from Chlamydomonas reinhardtii)
- Fadl (70 kDa, Protein from Chlamydomonas reinhardtii)
- Crtam31 (31 kDa, Protein from Chlamydomonas reinhardtii)
- Diacyl glycerol (625 Da, Ligand)
- Arhl (51 kDa, Protein from Chlamydomonas reinhardtii)
- Unk (13 kDa, Protein from Chlamydomonas reinhardtii)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Crtam15 (15 kDa, Protein from Chlamydomonas reinhardtii)
- Digalactosyl diacyl glycerol (dgdg) (949 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Crtam39 (39 kDa, Protein from Chlamydomonas reinhardtii)
- Crtam34 (34 kDa, Protein from Chlamydomonas reinhardtii)
- Crtam49 (48 kDa, Protein from Chlamydomonas reinhardtii)
- Crtam35 (34 kDa, Protein from Chlamydomonas reinhardtii)
Cryo-EM structure of the Ycf2-FtsHi motor complex from chlamydomonas reinhardtii in apo state
Liang K, Zhan X, Li Y, Yang Y, Xie Y, Jin Z, Xu X, Zhang W, Lu Y, Zhang S, Zou Y, Feng S, Wu J, Yan Z
Cell (2024) 187 pp. 5638-5650.e18 [ DOI: doi:10.1016/j.cell.2024.08.002 Pubmed: 39197449 ]
- Ctap7 (71 kDa, Protein from Chlamydomonas reinhardtii)
- Ctap1 (107 kDa, Protein from Chlamydomonas reinhardtii)
- Fhl3 (120 kDa, Protein from Chlamydomonas reinhardtii)
- Crtam29 (29 kDa, Protein from Chlamydomonas reinhardtii)
- 1,2-di-o-acyl-3-o-[6-deoxy-6-sulfo-alpha-d-glucopyranosyl]-sn-glycerol (795 Da, Ligand)
- 1,2-distearoyl-monogalactosyl-diglyceride (787 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Pcya (61 kDa, Protein from Chlamydomonas reinhardtii)
- Beta-sitosterol (416 Da, Ligand)
- Ycf2 (342 kDa, Protein from Chlamydomonas reinhardtii)
- Fhl1 (128 kDa, Protein from Chlamydomonas reinhardtii)
- Unk (7 kDa, Protein from Chlamydomonas reinhardtii)
- Dnaj (50 kDa, Protein from Chlamydomonas reinhardtii)
- Ctap6 (109 kDa, Protein from Chlamydomonas reinhardtii)
- Tic22 (40 kDa, Protein from Chlamydomonas reinhardtii)
- The ycf2-ftshi motor complex from chlamydomonas (Complex from Chlamydomonas reinhardtii)
- Acp (12 kDa, Protein from Chlamydomonas reinhardtii)
- Fadl (70 kDa, Protein from Chlamydomonas reinhardtii)
- Crtam31 (31 kDa, Protein from Chlamydomonas reinhardtii)
- Diacyl glycerol (625 Da, Ligand)
- Arhl (51 kDa, Protein from Chlamydomonas reinhardtii)
- Unk (13 kDa, Protein from Chlamydomonas reinhardtii)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Crtam15 (15 kDa, Protein from Chlamydomonas reinhardtii)
- Digalactosyl diacyl glycerol (dgdg) (949 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Crtam39 (39 kDa, Protein from Chlamydomonas reinhardtii)
- Crtam34 (34 kDa, Protein from Chlamydomonas reinhardtii)
- Crtam49 (48 kDa, Protein from Chlamydomonas reinhardtii)
- Crtam35 (34 kDa, Protein from Chlamydomonas reinhardtii)