Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with primidone
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 9b28
Q-score: 0.438
Yin Y, Park CG, Feng S, Guan Z, Lee HJ, Zhang F, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01463-8 Pubmed: 39809942 ]
- Primidone (218 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential cation channel, subfamily m, member 3 (198 kDa, Protein from Mus musculus)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 3 (Complex from Mus musculus)
Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with cholesteryl hemisuccinate
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 9b29
Q-score: 0.394
Yin Y, Park CG, Feng S, Guan Z, Lee HJ, Zhang F, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01463-8 Pubmed: 39809942 ]
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential cation channel, subfamily m, member 3 (198 kDa, Protein from Mus musculus)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 3 (Complex from Mus musculus)
Resolution: 3.82 Å
EM Method: Single-particle
Fitted PDBs: 9b2a
Q-score: 0.34
Yin Y, Park CG, Feng S, Guan Z, Lee HJ, Zhang F, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01463-8 Pubmed: 39809942 ]
- Pregnenolone sulfate (396 Da, Ligand)
- Transient receptor potential cation channel, subfamily m, member 3 (198 kDa, Protein from Mus musculus)
- (2s)-2-(3,4-dihydroquinolin-1(2h)-yl)-n-(5-methyl-1,2-oxazol-3-yl)-2-phenylacetamide (347 Da, Ligand)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 3 (Complex from Mus musculus)
Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014
Yin Y, Park CG, Zhang F, G Fedor J, Feng S, Suo Y, Im W, Lee SY
Sci Adv (2024) 10 pp. eadp2211-eadp2211 [ DOI: doi:10.1126/sciadv.adp2211 Pubmed: 39093967 ]
- Transient receptor potential cation channel subfamily m member 8 (Complex from Mus musculus)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1h-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene (467 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 8 (131 kDa, Protein from Mus musculus)
Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist AMG2850
Yin Y, Park CG, Zhang F, G Fedor J, Feng S, Suo Y, Im W, Lee SY
Sci Adv (2024) 10 pp. eadp2211-eadp2211 [ DOI: doi:10.1126/sciadv.adp2211 Pubmed: 39093967 ]
- Transient receptor potential cation channel subfamily m member 8 (Complex from Mus musculus)
- Cholesterol hemisuccinate (486 Da, Ligand)
- (8r)-8-[4-(trifluoromethyl)phenyl]-n-[(2s)-1,1,1-trifluoropropan-2-yl]-5,8-dihydro-1,7-naphthyridine-7(6h)-carboxamide (417 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 8 (131 kDa, Protein from Mus musculus)
Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist AMTB
Yin Y, Park CG, Zhang F, G Fedor J, Feng S, Suo Y, Im W, Lee SY
Sci Adv (2024) 10 pp. eadp2211-eadp2211 [ DOI: doi:10.1126/sciadv.adp2211 Pubmed: 39093967 ]
- Transient receptor potential cation channel subfamily m member 8 (Complex from Mus musculus)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 8 (131 kDa, Protein from Mus musculus)
- N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-n-[(thiophen-2-yl)methyl]benzamide (394 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Yin Y, Park CG, Zhang F, G Fedor J, Feng S, Suo Y, Im W, Lee SY
Sci Adv (2024) 10 pp. eadp2211-eadp2211 [ DOI: doi:10.1126/sciadv.adp2211 Pubmed: 39093967 ]
- Transient receptor potential cation channel subfamily m member 8 (Complex from Mus musculus)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 8 (131 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1h-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene (467 Da, Ligand)
- Nonyl(oxo)di(propan-2-yl)-lambda~5~-phosphane (260 Da, Ligand)
Cryo-EM structure of the avian great tit TRPM8 channel in complex with the antagonist TC-I 2014
Yin Y, Park CG, Zhang F, G Fedor J, Feng S, Suo Y, Im W, Lee SY
Sci Adv (2024) 10 pp. eadp2211-eadp2211 [ DOI: doi:10.1126/sciadv.adp2211 Pubmed: 39093967 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 8 (131 kDa, Protein from Parus major)
- Transient receptor potential cation channel subfamily m member 8 (Complex from Parus major)
- 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1h-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene (467 Da, Ligand)
Cryo-EM structure of the mouse TRPM8 channel in complex with PI(4,5)P2 and Ca2+
Yin Y, Park CG, Zhang F, G Fedor J, Feng S, Suo Y, Im W, Lee SY
Sci Adv (2024) 10 pp. eadp2211-eadp2211 [ DOI: doi:10.1126/sciadv.adp2211 Pubmed: 39093967 ]
- Transient receptor potential cation channel subfamily m member 8 (Complex from Mus musculus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 8 (131 kDa, Protein from Mus musculus)