Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8sun
Q-score: 0.43
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
Nat Commun (2023) 14 pp. 4874-4874 [ DOI: doi:10.1038/s41467-023-40410-x Pubmed: 37573365 ]
- 16f (Complex from Mus musculus)
- Anoctamin-6 (95 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1-hydroxy-3-(trifluoromethyl)pyrido[1,2-a]benzimidazole-4-carbonitrile (277 Da, Ligand)
TMEM16F bound with Niclosamide
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8sur
Q-score: 0.46
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
Nat Commun (2023) 14 pp. 4874-4874 [ DOI: doi:10.1038/s41467-023-40410-x Pubmed: 37573365 ]
- 16f (Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 5-chloro-n-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide (327 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Anoctamin-6 (106 kDa, Protein from Mus musculus)
TMEM16F, with Calcium and PIP2, no inhibitor
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8tag
Q-score: 0.452
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
Nat Commun (2023) 14 pp. 4874-4874 [ DOI: doi:10.1038/s41467-023-40410-x Pubmed: 37573365 ]
- 16f (Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Anoctamin-6 (95 kDa, Protein from Mus musculus)
TMEM16F, with Calcium and PIP2, no inhibitor, Cl2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8tai
Q-score: 0.466
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
Nat Commun (2023) 14 pp. 4874-4874 [ DOI: doi:10.1038/s41467-023-40410-x Pubmed: 37573365 ]
- 16f (Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Anoctamin-6 (95 kDa, Protein from Mus musculus)
TMEM16F, with Calcium and PIP2, no inhibitor, Cl1
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8tal
Q-score: 0.454
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
Nat Commun (2023) 14 pp. 4874-4874 [ DOI: doi:10.1038/s41467-023-40410-x Pubmed: 37573365 ]
- Calcium ion (40 Da, Ligand)
- 16f (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Anoctamin-6 (95 kDa, Protein from Mus musculus)
Cryo-EM structure of TMEM16F in digitonin with calcium bound
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6p46
Q-score: 0.403
Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y
Cell Rep (2019) 28 pp. 567-579.e4 [ Pubmed: 31291589 DOI: doi:10.1016/j.celrep.2019.06.023 ]
- Calcium ion (40 Da, Ligand)
- Anoctamin-6 (106 kDa, Protein from Mus musculus)
- Tmem16f with calcium bound (Complex from Mus musculus)
Cryo-EM structure of TMEM16F in digitonin without calcium
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6p47
Q-score: 0.365
Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y
Cell Rep (2019) 28 pp. 567-579.e4 [ DOI: doi:10.1016/j.celrep.2019.06.023 Pubmed: 31291589 ]
- Anoctamin-6 (106 kDa, Protein from Mus musculus)
- Tmem16f without calcium bound (Complex from Mus musculus)
Cryo-EM structure of calcium-bound TMEM16F in nanodisc with supplement of PIP2 in Cl1
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6p48
Q-score: 0.383
Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y
Cell Rep (2019) 28 pp. 567-579.e4 [ Pubmed: 31291589 DOI: doi:10.1016/j.celrep.2019.06.023 ]
- Calcium ion (40 Da, Ligand)
- Anoctamin-6 (106 kDa, Protein from Mus musculus)
- Tmem16f with calcium bound (Complex from Mus musculus)
Cryo-EM structure of calcium-bound TMEM16F in nanodisc with supplement of PIP2 in Cl2
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6p49
Q-score: 0.338
Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y
Cell Rep (2019) 28 pp. 567-579.e4 [ Pubmed: 31291589 DOI: doi:10.1016/j.celrep.2019.06.023 ]
- Calcium ion (40 Da, Ligand)
- Anoctamin-6 (106 kDa, Protein from Mus musculus)
- Tmem16f with calcium bound (Complex from Mus musculus)