Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK2798745
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8fc7
Q-score: 0.421
Kwon DH, Zhang F, McCray BA, Feng S, Kumar M, Sullivan JM, Im W, Sumner CJ, Lee SY
Nat Commun (2023) 14 pp. 3732-3732 [ Pubmed: 37353484 DOI: doi:10.1038/s41467-023-39345-0 ]
- The complex of human trpv4 with rhoa (450 kDa, Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Transforming protein rhoa (21 kDa, Protein from Homo sapiens)
- 1-({(5s,7s)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1h-benzimidazole-6-carbonitrile (460 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 4 (102 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human TRPV4 in complex with GSK1016790A
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 8fc8
Q-score: 0.403
Kwon DH, Zhang F, McCray BA, Feng S, Kumar M, Sullivan JM, Im W, Sumner CJ, Lee SY
Nat Commun (2023) 14 pp. 3732-3732 [ Pubmed: 37353484 DOI: doi:10.1038/s41467-023-39345-0 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- N-[(2s)-1-{4-[n-(2,4-dichlorobenzene-1-sulfonyl)-l-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide (655 Da, Ligand)
- The complex of human trpv4 with rhoa (450 kDa, Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily v member 4 (102 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human TRPV4 - RhoA, apo condition
Resolution: 3.75 Å
EM Method: Single-particle
Fitted PDBs: 8fc9
Q-score: 0.282
Kwon DH, Zhang F, McCray BA, Feng S, Kumar M, Sullivan JM, Im W, Sumner CJ, Lee SY
Nat Commun (2023) 14 pp. 3732-3732 [ Pubmed: 37353484 DOI: doi:10.1038/s41467-023-39345-0 ]
- The complex of human trpv4 with rhoa (450 kDa, Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Transforming protein rhoa (21 kDa, Protein from Homo sapiens)
- Transient receptor potential cation channel subfamily v member 4 (102 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human TRPV4 - RhoA in complex with 4alpha-Phorbol 12,13-didecanoate
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8fca
Q-score: 0.408
Kwon DH, Zhang F, McCray BA, Feng S, Kumar M, Sullivan JM, Im W, Sumner CJ, Lee SY
Nat Commun (2023) 14 pp. 3732-3732 [ Pubmed: 37353484 DOI: doi:10.1038/s41467-023-39345-0 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- (1ar,1bs,4as,7as,7bs,8r,9r,9as)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1h-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate (672 Da, Ligand)
- The complex of human trpv4 with rhoa (450 kDa, Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily v member 4 (102 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK2798745, TRPV4 focused refinement map
Kwon DH, Zhang F, McCray BA, Feng S, Kumar M, Sullivan JM, Im W, Sumner CJ, Lee SY
Nat Commun (2023) 14 pp. 3732-3732 [ Pubmed: 37353484 DOI: doi:10.1038/s41467-023-39345-0 ]
- Human trpv4 - human rhoa (Macromolecule from Homo sapiens)
- The complex of human trpv4 with rhoa (450 kDa, Complex from Homo sapiens)
Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK2798745, RhoA focused refinement map
Kwon DH, Zhang F, McCray BA, Feng S, Kumar M, Sullivan JM, Im W, Sumner CJ, Lee SY
Nat Commun (2023) 14 pp. 3732-3732 [ Pubmed: 37353484 DOI: doi:10.1038/s41467-023-39345-0 ]
- Human rhoa (Macromolecule from Homo sapiens)
- The complex of human trpv4 with rhoa (450 kDa, Complex from Homo sapiens)
- Human trpv4 (Macromolecule from Homo sapiens)
Cryo-EM structure of the human TRPV4 in complex with GSK1016790A, TRPV4 focused refinement map
Kwon DH, Zhang F, McCray BA, Feng S, Kumar M, Sullivan JM, Im W, Sumner CJ, Lee SY
Nat Commun (2023) 14 pp. 3732-3732 [ Pubmed: 37353484 DOI: doi:10.1038/s41467-023-39345-0 ]
- Human trpv4 (Protein from Homo sapiens)
- The complex of human trpv4 with rhoa (450 kDa, Complex from Homo sapiens)
Cryo-EM structure of the human TRPV4 in complex with GSK1016790A, RhoA focused refinement map
Kwon DH, Zhang F, McCray BA, Feng S, Kumar M, Sullivan JM, Im W, Sumner CJ, Lee SY
Nat Commun (2023) 14 pp. 3732-3732 [ DOI: doi:10.1038/s41467-023-39345-0 Pubmed: 37353484 ]
- Human rhoa (Macromolecule from Homo sapiens)
- The complex of human trpv4 with rhoa (450 kDa, Complex from Homo sapiens)
- Human trpv4 (Macromolecule from Homo sapiens)