Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK2798745
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8fc7
Q-score: 0.421
Kwon DH, Zhang F, McCray BA, Feng S, Kumar M, Sullivan JM, Im W, Sumner CJ, Lee SY
Nat Commun (2023) 14 pp. 3732-3732 [ Pubmed: 37353484 DOI: doi:10.1038/s41467-023-39345-0 ]
- Transforming protein rhoa (21 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 4 (102 kDa, Protein from Homo sapiens)
- 1-({(5s,7s)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1h-benzimidazole-6-carbonitrile (460 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- The complex of human trpv4 with rhoa (450 kDa, Complex from Homo sapiens)
Cryo-EM structure of the human TRPV4 in complex with GSK1016790A
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 8fc8
Q-score: 0.403
Kwon DH, Zhang F, McCray BA, Feng S, Kumar M, Sullivan JM, Im W, Sumner CJ, Lee SY
Nat Commun (2023) 14 pp. 3732-3732 [ Pubmed: 37353484 DOI: doi:10.1038/s41467-023-39345-0 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 4 (102 kDa, Protein from Homo sapiens)
- The complex of human trpv4 with rhoa (450 kDa, Complex from Homo sapiens)
- N-[(2s)-1-{4-[n-(2,4-dichlorobenzene-1-sulfonyl)-l-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide (655 Da, Ligand)
Cryo-EM structure of the human TRPV4 - RhoA, apo condition
Resolution: 3.75 Å
EM Method: Single-particle
Fitted PDBs: 8fc9
Q-score: 0.282
Kwon DH, Zhang F, McCray BA, Feng S, Kumar M, Sullivan JM, Im W, Sumner CJ, Lee SY
Nat Commun (2023) 14 pp. 3732-3732 [ Pubmed: 37353484 DOI: doi:10.1038/s41467-023-39345-0 ]
- Transforming protein rhoa (21 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 4 (102 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- The complex of human trpv4 with rhoa (450 kDa, Complex from Homo sapiens)
Cryo-EM structure of the human TRPV4 - RhoA in complex with 4alpha-Phorbol 12,13-didecanoate
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8fca
Q-score: 0.408
Kwon DH, Zhang F, McCray BA, Feng S, Kumar M, Sullivan JM, Im W, Sumner CJ, Lee SY
Nat Commun (2023) 14 pp. 3732-3732 [ Pubmed: 37353484 DOI: doi:10.1038/s41467-023-39345-0 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 4 (102 kDa, Protein from Homo sapiens)
- The complex of human trpv4 with rhoa (450 kDa, Complex from Homo sapiens)
- (1ar,1bs,4as,7as,7bs,8r,9r,9as)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1h-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate (672 Da, Ligand)