Local refined cryo-EM reconstruction of Omicron BA.5 RBD in complex with 8-9D Fab
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8j1t
Q-score: 0.455
Tai W, Yang K, Liu Y, Li R, Feng S, Chai B, Zhuang X, Qi S, Shi H, Liu Z, Lei J, Ma E, Wang W, Tian C, Le T, Wang J, Chen Y, Tian M, Xiang Y, Yu G, Cheng G
Nat Commun (2023) 14 pp. 8042-8042 [ DOI: doi:10.1038/s41467-023-43798-8 Pubmed: 38052844 ]
- Sars-cov2 omicron ba.5 rbd (Complex)
- 8-9d light chain (11 kDa, Protein from Homo sapiens)
- 8-9d fab (Complex from Homo sapiens)
- Severe acute respiratory syndrome coronavirus 2 omicron ba.5 rbd bound 8-9d fab (22 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- 8-9d heavy chain (12 kDa, Protein from Homo sapiens)
- Spike protein (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM reconstruction of SARS-CoV2 Omicron BA.5 spike in complex with 8-9D Fabs
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8j1v
Q-score: 0.374
Tai W, Yang K, Liu Y, Li R, Feng S, Chai B, Zhuang X, Qi S, Shi H, Liu Z, Lei J, Ma E, Wang W, Tian C, Le T, Wang J, Chen Y, Tian M, Xiang Y, Yu G, Cheng G
Nat Commun (2023) 14 pp. 8042-8042 [ DOI: doi:10.1038/s41467-023-43798-8 Pubmed: 38052844 ]
- 8-9d fab variable region (Complex from Homo sapiens)
- Severe acute respiratory syndrome coronavirus 2 omicron ba.5 spike bound 8-9d fab (369 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- 8-9d light chain (11 kDa, Protein from Homo sapiens)
- Spike protein s2' (123 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 8-9d heavy chain (12 kDa, Protein from Homo sapiens)
- Sars-cov2 omicron ba.5 spike ectodomain (Complex)
Cryo-EM structure of human ZDHHC9/GCP16 complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8hf3
Q-score: 0.496
Yang A, Liu S, Zhang Y, Chen J, Fan Y, Wang F, Zou Y, Feng S, Wu J, Hu Q
Nat Struct Mol Biol (2024) 31 pp. 436-446 [ DOI: doi:10.1038/s41594-023-01183-5 Pubmed: 38182928 ]
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Golgin subfamily a member 7 (16 kDa, Protein from Homo sapiens)
- Human zdhhc9/gcp16 complex (Complex from Homo sapiens)
- Palmitoyltransferase zdhhc9 (41 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Cryo-EM structure of yeast Erf2/Erf4 complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8hfc
Q-score: 0.503
Yang A, Liu S, Zhang Y, Chen J, Fan Y, Wang F, Zou Y, Feng S, Wu J, Hu Q
Nat Struct Mol Biol (2024) 31 pp. 436-446 [ DOI: doi:10.1038/s41594-023-01183-5 Pubmed: 38182928 ]
- Erf2/erf4 complex (Complex from Saccharomyces cerevisiae)
- Ras modification protein erf4 (29 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Palmitoyltransferase erf2 (43 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Palmitic acid (256 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8sun
Q-score: 0.43
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
Nat Commun (2023) 14 pp. 4874-4874 [ DOI: doi:10.1038/s41467-023-40410-x Pubmed: 37573365 ]
- 16f (Complex from Mus musculus)
- Anoctamin-6 (95 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1-hydroxy-3-(trifluoromethyl)pyrido[1,2-a]benzimidazole-4-carbonitrile (277 Da, Ligand)
TMEM16F bound with Niclosamide
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8sur
Q-score: 0.46
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
Nat Commun (2023) 14 pp. 4874-4874 [ DOI: doi:10.1038/s41467-023-40410-x Pubmed: 37573365 ]
- 16f (Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 5-chloro-n-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide (327 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Anoctamin-6 (106 kDa, Protein from Mus musculus)
TMEM16F, with Calcium and PIP2, no inhibitor
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8tag
Q-score: 0.452
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
Nat Commun (2023) 14 pp. 4874-4874 [ DOI: doi:10.1038/s41467-023-40410-x Pubmed: 37573365 ]
- 16f (Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Anoctamin-6 (95 kDa, Protein from Mus musculus)
TMEM16F, with Calcium and PIP2, no inhibitor, Cl2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8tai
Q-score: 0.466
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
Nat Commun (2023) 14 pp. 4874-4874 [ DOI: doi:10.1038/s41467-023-40410-x Pubmed: 37573365 ]
- 16f (Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Anoctamin-6 (95 kDa, Protein from Mus musculus)
TMEM16F, with Calcium and PIP2, no inhibitor, Cl1
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8tal
Q-score: 0.454
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
Nat Commun (2023) 14 pp. 4874-4874 [ DOI: doi:10.1038/s41467-023-40410-x Pubmed: 37573365 ]
- Calcium ion (40 Da, Ligand)
- 16f (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Anoctamin-6 (95 kDa, Protein from Mus musculus)
Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK2798745
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8fc7
Q-score: 0.421
Kwon DH, Zhang F, McCray BA, Feng S, Kumar M, Sullivan JM, Im W, Sumner CJ, Lee SY
Nat Commun (2023) 14 pp. 3732-3732 [ Pubmed: 37353484 DOI: doi:10.1038/s41467-023-39345-0 ]
- The complex of human trpv4 with rhoa (450 kDa, Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Transforming protein rhoa (21 kDa, Protein from Homo sapiens)
- 1-({(5s,7s)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1h-benzimidazole-6-carbonitrile (460 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 4 (102 kDa, Protein from Homo sapiens)