Structure of the human TREX core THO-UAP56 complex (map D)
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 7znl
Q-score: 0.069
Pacheco-Fiallos B, Vorlander MK, Riabov-Bassat D, Fin L, O'Reilly FJ, Ayala FI, Schellhaas U, Rappsilber J, Plaschka C
Nature (2023) 616 pp. 828-835 [ DOI: doi:10.1038/s41586-023-05904-0 Pubmed: 37020021 ]
- Tho-uap56 (1 MDa, Complex from Homo sapiens)
- Spliceosome rna helicase ddx39b (49 kDa, Protein from Homo sapiens)
- Tho complex subunit 3 (38 kDa, Protein from Homo sapiens)
- Tho complex subunit 5 homolog (78 kDa, Protein from Homo sapiens)
- Tho complex subunit 1 (75 kDa, Protein from Homo sapiens)
- Tho complex subunit 6 homolog (37 kDa, Protein from Homo sapiens)
- Tho complex subunit 7 homolog (23 kDa, Protein from Homo sapiens)
- Tho complex subunit 2 (183 kDa, Protein from Homo sapiens)
Composite map of the human TREX core THO-UAP56 complex
Pacheco-Fiallos B, Vorlander MK, Riabov-Bassat D, Fin L, O'Reilly FJ, Ayala FI, Schellhaas U, Rappsilber J, Plaschka C
Nature (2023) 616 pp. 828-835 [ DOI: doi:10.1038/s41586-023-05904-0 Pubmed: 37020021 ]
- Tho-uap56 (1 MDa, Complex from Homo sapiens)
Structure of an endogenous human TREX complex bound to mRNA, composite map
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7znk
Q-score: 0.139
Pacheco-Fiallos B, Vorlander MK, Riabov-Bassat D, Fin L, O'Reilly FJ, Ayala FI, Schellhaas U, Rappsilber J, Plaschka C
Nature (2023) 616 pp. 828-835 [ DOI: doi:10.1038/s41586-023-05904-0 Pubmed: 37020021 ]
- Spliceosome rna helicase ddx39b (49 kDa, Protein from Homo sapiens)
- Tho complex subunit 3 (38 kDa, Protein from Homo sapiens)
- Tho complex subunit 4 (26 kDa, Protein from Homo sapiens)
- Tho complex subunit 1 (75 kDa, Protein from Homo sapiens)
- Endogenous human trex-mrna complex (1 MDa, Complex from Homo sapiens)
- Tho complex subunit 6 homolog (37 kDa, Protein from Homo sapiens)
- Tho complex subunit 7 homolog (23 kDa, Protein from Homo sapiens)
- Tho complex subunit 2 (183 kDa, Protein from Homo sapiens)
- Tho complex subunit 5 homolog (78 kDa, Protein from Homo sapiens)
- Rna (873 Da, RNA from Homo sapiens)
Tomogram of purified human TREX-mRNPs
Pacheco-Fiallos B, Vorlander MK, Riabov-Bassat D, Fin L, O'Reilly FJ, Ayala FI, Schellhaas U, Rappsilber J, Plaschka C
Nature (2023) 616 pp. 828-835 [ DOI: doi:10.1038/s41586-023-05904-0 Pubmed: 37020021 ]
- Endogenous human transcription-export complex (1 MDa, Complex from Homo sapiens)
Structure of an endogenous human TREX complex bound to mRNA, map A
Pacheco-Fiallos B, Vorlander MK, Riabov-Bassat D, Fin L, O'Reilly FJ, Ayala FI, Schellhaas U, Rappsilber J, Plaschka C
Nature (2023) 616 pp. 828-835 [ DOI: doi:10.1038/s41586-023-05904-0 Pubmed: 37020021 ]
- Endogenous human trex-mrna complex (1 MDa, Complex from Homo sapiens)
Structure of an endogenous human TREX complex bound to mRNA, map B
Pacheco-Fiallos B, Vorlander MK, Riabov-Bassat D, Fin L, O'Reilly FJ, Ayala FI, Schellhaas U, Rappsilber J, Plaschka C
Nature (2023) 616 pp. 828-835 [ DOI: doi:10.1038/s41586-023-05904-0 Pubmed: 37020021 ]
- Endogenous human trex-mrna complex (1 MDa, Complex from Homo sapiens)
Structure of an endogenous human TREX complex bound to mRNA, map C
Pacheco-Fiallos B, Vorlander MK, Riabov-Bassat D, Fin L, O'Reilly FJ, Ayala FI, Schellhaas U, Rappsilber J, Plaschka C
Nature (2023) 616 pp. 828-835 [ DOI: doi:10.1038/s41586-023-05904-0 Pubmed: 37020021 ]
- Endogenous human trex-mrna complex (1 MDa, Complex from Homo sapiens)
Structure of the human TREX core THO-UAP56 complex (map E)
Pacheco-Fiallos B, Vorlander MK, Riabov-Bassat D, Fin L, O'Reilly FJ, Ayala FI, Schellhaas U, Rappsilber J, Plaschka C
Nature (2023) 616 pp. 828-835 [ DOI: doi:10.1038/s41586-023-05904-0 Pubmed: 37020021 ]
- Tho-uap56 (1 MDa, Complex from Homo sapiens)
Structure of an ALYREF-exon junction complex hexamer, obtained from TREX-EJC-RNA sample
Pacheco-Fiallos B, Vorlander MK, Riabov-Bassat D, Fin L, O'Reilly FJ, Ayala FI, Schellhaas U, Rappsilber J, Plaschka C
Nature (2023) 616 pp. 828-835 [ DOI: doi:10.1038/s41586-023-05904-0 Pubmed: 37020021 ]
Structure of an ALYREF-exon junction complex hexamer
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7znj
Q-score: 0.608
Pacheco-Fiallos B, Vorlander MK, Riabov-Bassat D, Fin L, O'Reilly FJ, Ayala FI, Schellhaas U, Rappsilber J, Plaschka C
Nature (2023) 616 pp. 828-835 [ DOI: doi:10.1038/s41586-023-05904-0 Pubmed: 37020021 ]
- Hexameric complex between the trex subunit alyref and the exon junction complex (650 kDa, Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Rna (1 kDa, RNA from Homo sapiens)
- Eukaryotic initiation factor 4a-iii, n-terminally processed (43 kDa, Protein from Homo sapiens)
- Rna-binding protein 8a (10 kDa, Protein from Homo sapiens)
- Maltose/maltodextrin-binding periplasmic protein,tho complex subunit 4 (57 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Protein mago nashi homolog (17 kDa, Protein from Homo sapiens)