Integrative Structure of the human intron lariat Spliceosome (ILS'')
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8ro2
Q-score: 0.297
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ Pubmed: 38925148 DOI: doi:10.1038/s41586-024-07741-1 ]
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor isy1 homolog (33 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor syf2 (28 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Homo sapiens)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
- U2 snrna (60 kDa, RNA from Homo sapiens)
- Cwf19-like protein 1 (60 kDa, Protein from Homo sapiens)
- Pre-mrna-processing factor 17 (65 kDa, Protein from Homo sapiens)
- Crooked neck-like protein 1 (100 kDa, Protein from Homo sapiens)
- Coiled-coil domain-containing protein 12 (19 kDa, Protein from Homo sapiens)
- U6 snrna (34 kDa, RNA from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- Tuftelin-interacting protein 11 (96 kDa, Protein from Homo sapiens)
- Protein bud31 homolog (17 kDa, Protein from Homo sapiens)
- U5 snrna (36 kDa, RNA from Homo sapiens)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
- Pax3- and pax7-binding protein 1 (104 kDa, Protein from Homo sapiens)
- Atp-dependent rna helicase dhx15 (91 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- Intron (30 kDa, RNA from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from Homo sapiens)
- Snw domain-containing protein 1 (61 kDa, Protein from Homo sapiens)
- Splicing regulator sde2 (49 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- Human intron-lariat splicoesome (Complex from Homo sapiens)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Pleiotropic regulator 1 (57 kDa, Protein from Homo sapiens)
- Cell division cycle 5-like protein (92 kDa, Protein from Homo sapiens)
- Pre-mrna-processing factor 19 (55 kDa, Protein from Homo sapiens)
- Cwf19-like protein 2 (103 kDa, Protein from Homo sapiens)
- Intron-binding protein aquarius (171 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor syf1 (100 kDa, Protein from Homo sapiens)
- Splicing factor ess-2 homolog (52 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor spf27 (26 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Homo sapiens)
Composite map of the C. elegans Intron Lariat Spliceosome primed for disassembly (ILS')
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8ro0
Q-score: 0.372
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ Pubmed: 38925148 DOI: doi:10.1038/s41586-024-07741-1 ]
- Protein isy-1 (31 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein f (9 kDa, Protein from Caenorhabditis elegans)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Caenorhabditis elegans)
- Uncharacterized protein t27f2.1 (60 kDa, Protein from Caenorhabditis elegans)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Caenorhabditis elegans)
- Tr-type g domain-containing protein (110 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein e (10 kDa, Protein from Caenorhabditis elegans)
- Intron-binding protein aquarius (170 kDa, Protein from Caenorhabditis elegans)
- Septin and tuftelin-interacting protein 1 homolog (94 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein-associated protein b (16 kDa, Protein from Caenorhabditis elegans)
- Peptidyl-prolyl cis-trans isomerase e (36 kDa, Protein from Caenorhabditis elegans)
- Cell division cycle 5-like protein (85 kDa, Protein from Caenorhabditis elegans)
- Tpr_region domain-containing protein (88 kDa, Protein from Caenorhabditis elegans)
- Wd_repeats_region domain-containing protein (36 kDa, Protein from Caenorhabditis elegans)
- Gcf c-terminal domain-containing protein (94 kDa, Protein from Caenorhabditis elegans)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Caenorhabditis elegans)
- U5 snrna (38 kDa, RNA from Caenorhabditis elegans)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pre-mrna-splicing factor rbm22 (45 kDa, Protein from Caenorhabditis elegans)
- Wd_repeats_region domain-containing protein (54 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor syf1 (99 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor 8 homolog (272 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor spf27 (27 kDa, Protein from Caenorhabditis elegans)
- Rrm domain-containing protein (24 kDa, Protein from Caenorhabditis elegans)
- U6 snrna (32 kDa, RNA from Caenorhabditis elegans)
- U2 snrna (56 kDa, RNA from Caenorhabditis elegans)
- Pre-mrna-processing factor 19 (53 kDa, Protein from Caenorhabditis elegans)
- Magnesium ion (24 Da, Ligand)
- Inositol hexakisphosphate (660 Da, Ligand)
- Probable u2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Caenorhabditis elegans)
- Zinc ion (65 Da, Ligand)
- Intron lariat rna (3 kDa, DNA from Caenorhabditis elegans)
- Pre-mrna-splicing factor syf-2 (27 kDa, Protein from Caenorhabditis elegans)
- Intron lariat spliceosome (Complex from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein g (8 kDa, Protein from Caenorhabditis elegans)
- Protein bud31 homolog (17 kDa, Protein from Caenorhabditis elegans)
- Peptidyl-prolyl cis-trans isomerase (18 kDa, Protein from Caenorhabditis elegans)
- Wd_repeats_region domain-containing protein (65 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Caenorhabditis elegans)
- Coiled-coil domain-containing protein 12 (19 kDa, Protein from Caenorhabditis elegans)
- Small nuclear ribonucleoprotein sm d3 (14 kDa, Protein from Caenorhabditis elegans)
Structure of the C. elegans Intron Lariat Spliceosome double-primed for disassembly (ILS'')
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8ro1
Q-score: 0.373
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ Pubmed: 38925148 DOI: doi:10.1038/s41586-024-07741-1 ]
- Protein isy-1 (31 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein f (9 kDa, Protein from Caenorhabditis elegans)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Caenorhabditis elegans)
- Uncharacterized protein t27f2.1 (60 kDa, Protein from Caenorhabditis elegans)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Caenorhabditis elegans)
- Tr-type g domain-containing protein (110 kDa, Protein from Caenorhabditis elegans)
- Intron lariat rna (10 kDa, RNA from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein e (10 kDa, Protein from Caenorhabditis elegans)
- Intron-binding protein aquarius (170 kDa, Protein from Caenorhabditis elegans)
- Septin and tuftelin-interacting protein 1 homolog (94 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein-associated protein b (16 kDa, Protein from Caenorhabditis elegans)
- Peptidyl-prolyl cis-trans isomerase e (8 kDa, Protein from Caenorhabditis elegans)
- Cell division cycle 5-like protein (85 kDa, Protein from Caenorhabditis elegans)
- Wd_repeats_region domain-containing protein (36 kDa, Protein from Caenorhabditis elegans)
- Tpr_region domain-containing protein (88 kDa, Protein from Caenorhabditis elegans)
- Cwf19-like protein 1 homolog (59 kDa, Protein from Caenorhabditis elegans)
- U2 snrna (68 kDa, RNA from Caenorhabditis elegans)
- Pre-mrna-splicing factor atp-dependent rna helicase ddx-15 (84 kDa, Protein from Caenorhabditis elegans)
- Gcf c-terminal domain-containing protein (94 kDa, Protein from Caenorhabditis elegans)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pre-mrna-splicing factor rbm22 (45 kDa, Protein from Caenorhabditis elegans)
- Intron lariat spliceosome (ils'') (Complex from Caenorhabditis elegans)
- Wd_repeats_region domain-containing protein (54 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor syf1 (99 kDa, Protein from Caenorhabditis elegans)
- U5 snrna (35 kDa, RNA from Caenorhabditis elegans)
- Pre-mrna-splicing factor 8 homolog (272 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor spf27 (27 kDa, Protein from Caenorhabditis elegans)
- Rrm domain-containing protein (24 kDa, Protein from Caenorhabditis elegans)
- U6 snrna (32 kDa, RNA from Caenorhabditis elegans)
- Pre-mrna-processing factor 19 (53 kDa, Protein from Caenorhabditis elegans)
- Replication stress response regulator sde2 (57 kDa, Protein from Caenorhabditis elegans)
- Magnesium ion (24 Da, Ligand)
- Coiled-coil domain-containing protein 12 (8 kDa, Protein from Caenorhabditis elegans)
- Probable u2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Caenorhabditis elegans)
- Zinc ion (65 Da, Ligand)
- Pre-mrna-splicing factor syf-2 (27 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein g (8 kDa, Protein from Caenorhabditis elegans)
- Protein bud31 homolog (17 kDa, Protein from Caenorhabditis elegans)
- Cwf19-like protein 2 homolog (53 kDa, Protein from Caenorhabditis elegans)
- Peptidyl-prolyl cis-trans isomerase (18 kDa, Protein from Caenorhabditis elegans)
- Wd_repeats_region domain-containing protein (65 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Caenorhabditis elegans)
- Inositol hexakisphosphate (660 Da, Ligand)
- Small nuclear ribonucleoprotein sm d3 (14 kDa, Protein from Caenorhabditis elegans)
Structure of the C. elegans Intron Lariat Spliceosome (Map 1)
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ Pubmed: 38925148 DOI: doi:10.1038/s41586-024-07741-1 ]
Structure of the C. elegans Intron Lariat Spliceosome (Map 2)
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ Pubmed: 38925148 DOI: doi:10.1038/s41586-024-07741-1 ]
Structure of the C. elegans Intron Lariat Spliceosome (Map 3)
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ Pubmed: 38925148 DOI: doi:10.1038/s41586-024-07741-1 ]
Structure of the C. elegans Intron Lariat Spliceosome (Map 4)
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ Pubmed: 38925148 DOI: doi:10.1038/s41586-024-07741-1 ]
Structure of the C. elegans Intron Lariat Spliceosome (Map 5)
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ Pubmed: 38925148 DOI: doi:10.1038/s41586-024-07741-1 ]
Structure of the C. elegans Intron Lariat Spliceosome (Map 6)
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ Pubmed: 38925148 DOI: doi:10.1038/s41586-024-07741-1 ]
Structure of the C. elegans Intron Lariat Spliceosome (Map 7)
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ Pubmed: 38925148 DOI: doi:10.1038/s41586-024-07741-1 ]