Composite map of the C. elegans Intron Lariat Spliceosome primed for disassembly (ILS')
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8ro0
Q-score: 0.372
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ Pubmed: 38925148 DOI: doi:10.1038/s41586-024-07741-1 ]
- Protein isy-1 (31 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein f (9 kDa, Protein from Caenorhabditis elegans)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Caenorhabditis elegans)
- Uncharacterized protein t27f2.1 (60 kDa, Protein from Caenorhabditis elegans)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Caenorhabditis elegans)
- Tr-type g domain-containing protein (110 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein e (10 kDa, Protein from Caenorhabditis elegans)
- Intron-binding protein aquarius (170 kDa, Protein from Caenorhabditis elegans)
- Septin and tuftelin-interacting protein 1 homolog (94 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein-associated protein b (16 kDa, Protein from Caenorhabditis elegans)
- Peptidyl-prolyl cis-trans isomerase e (36 kDa, Protein from Caenorhabditis elegans)
- Cell division cycle 5-like protein (85 kDa, Protein from Caenorhabditis elegans)
- Tpr_region domain-containing protein (88 kDa, Protein from Caenorhabditis elegans)
- Wd_repeats_region domain-containing protein (36 kDa, Protein from Caenorhabditis elegans)
- Gcf c-terminal domain-containing protein (94 kDa, Protein from Caenorhabditis elegans)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Caenorhabditis elegans)
- U5 snrna (38 kDa, RNA from Caenorhabditis elegans)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pre-mrna-splicing factor rbm22 (45 kDa, Protein from Caenorhabditis elegans)
- Wd_repeats_region domain-containing protein (54 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor syf1 (99 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor 8 homolog (272 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor spf27 (27 kDa, Protein from Caenorhabditis elegans)
- Rrm domain-containing protein (24 kDa, Protein from Caenorhabditis elegans)
- U6 snrna (32 kDa, RNA from Caenorhabditis elegans)
- U2 snrna (56 kDa, RNA from Caenorhabditis elegans)
- Pre-mrna-processing factor 19 (53 kDa, Protein from Caenorhabditis elegans)
- Magnesium ion (24 Da, Ligand)
- Inositol hexakisphosphate (660 Da, Ligand)
- Probable u2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Caenorhabditis elegans)
- Zinc ion (65 Da, Ligand)
- Intron lariat rna (3 kDa, DNA from Caenorhabditis elegans)
- Pre-mrna-splicing factor syf-2 (27 kDa, Protein from Caenorhabditis elegans)
- Intron lariat spliceosome (Complex from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein g (8 kDa, Protein from Caenorhabditis elegans)
- Protein bud31 homolog (17 kDa, Protein from Caenorhabditis elegans)
- Peptidyl-prolyl cis-trans isomerase (18 kDa, Protein from Caenorhabditis elegans)
- Wd_repeats_region domain-containing protein (65 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Caenorhabditis elegans)
- Coiled-coil domain-containing protein 12 (19 kDa, Protein from Caenorhabditis elegans)
- Small nuclear ribonucleoprotein sm d3 (14 kDa, Protein from Caenorhabditis elegans)
Structure of the C. elegans Intron Lariat Spliceosome (Map 1)
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ Pubmed: 38925148 DOI: doi:10.1038/s41586-024-07741-1 ]
Structure of the C. elegans Intron Lariat Spliceosome (Map 2)
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ Pubmed: 38925148 DOI: doi:10.1038/s41586-024-07741-1 ]
Structure of the C. elegans Intron Lariat Spliceosome (Map 3)
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ Pubmed: 38925148 DOI: doi:10.1038/s41586-024-07741-1 ]
Structure of the C. elegans Intron Lariat Spliceosome (Map 10)
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ Pubmed: 38925148 DOI: doi:10.1038/s41586-024-07741-1 ]
Structure of the C. elegans Intron Lariat Spliceosome (Map 18)
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ Pubmed: 38925148 DOI: doi:10.1038/s41586-024-07741-1 ]
Structure of the recycling U5 snRNP bound to chaperone CD2BP2 and TSSC4 (Map 5)
Riabov Bassat D, Visanpattanasin S, Vorlander MK, Fin L, Phillips AW, Plaschka C
Nat Struct Mol Biol (2024) 31 pp. 747-751 [ Pubmed: 38467876 DOI: doi:10.1038/s41594-024-01243-4 ]
Structure of the recycling U5 snRNP bound to chaperone CD2BP2 and TSSC4 (Map 6)
Riabov Bassat D, Visanpattanasin S, Vorlander MK, Fin L, Phillips AW, Plaschka C
Nat Struct Mol Biol (2024) 31 pp. 747-751 [ Pubmed: 38467876 DOI: doi:10.1038/s41594-024-01243-4 ]
Structure of an ALYREF-exon junction complex hexamer
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7znj
Q-score: 0.608
Pacheco-Fiallos B, Vorlander MK, Riabov-Bassat D, Fin L, O'Reilly FJ, Ayala FI, Schellhaas U, Rappsilber J, Plaschka C
Nature (2023) 616 pp. 828-835 [ DOI: doi:10.1038/s41586-023-05904-0 Pubmed: 37020021 ]
- Maltose/maltodextrin-binding periplasmic protein,tho complex subunit 4 (57 kDa, Protein from Homo sapiens)
- Rna-binding protein 8a (10 kDa, Protein from Homo sapiens)
- Rna (1 kDa, RNA from Homo sapiens)
- Protein mago nashi homolog (17 kDa, Protein from Homo sapiens)
- Hexameric complex between the trex subunit alyref and the exon junction complex (650 kDa, Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Eukaryotic initiation factor 4a-iii, n-terminally processed (43 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)