Integrative Structure of the human intron lariat Spliceosome (ILS'')
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8ro2
Q-score: 0.297
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ DOI: doi:10.1038/s41586-024-07741-1 Pubmed: 38925148 ]
- Cell division cycle 5-like protein (92 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Homo sapiens)
- Pre-mrna-processing factor 19 (55 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor isy1 homolog (33 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor spf27 (26 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Protein bud31 homolog (17 kDa, Protein from Homo sapiens)
- Cwf19-like protein 2 (103 kDa, Protein from Homo sapiens)
- Coiled-coil domain-containing protein 12 (19 kDa, Protein from Homo sapiens)
- U2 snrna (60 kDa, RNA from Homo sapiens)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- Pre-mrna-processing factor 17 (65 kDa, Protein from Homo sapiens)
- U5 snrna (36 kDa, RNA from Homo sapiens)
- Atp-dependent rna helicase dhx15 (91 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Pleiotropic regulator 1 (57 kDa, Protein from Homo sapiens)
- Human intron-lariat splicoesome (Complex from Homo sapiens)
- Tuftelin-interacting protein 11 (96 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor syf1 (100 kDa, Protein from Homo sapiens)
- U6 snrna (34 kDa, RNA from Homo sapiens)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Splicing regulator sde2 (49 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- Snw domain-containing protein 1 (61 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor syf2 (28 kDa, Protein from Homo sapiens)
- Pax3- and pax7-binding protein 1 (104 kDa, Protein from Homo sapiens)
- Crooked neck-like protein 1 (100 kDa, Protein from Homo sapiens)
- Cwf19-like protein 1 (60 kDa, Protein from Homo sapiens)
- Intron (30 kDa, RNA from Homo sapiens)
- Splicing factor ess-2 homolog (52 kDa, Protein from Homo sapiens)
- Intron-binding protein aquarius (171 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
Composite map of the C. elegans Intron Lariat Spliceosome primed for disassembly (ILS')
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8ro0
Q-score: 0.372
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ DOI: doi:10.1038/s41586-024-07741-1 Pubmed: 38925148 ]
- Tr-type g domain-containing protein (110 kDa, Protein from Caenorhabditis elegans)
- U5 snrna (38 kDa, RNA from Caenorhabditis elegans)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Caenorhabditis elegans)
- Protein isy-1 (31 kDa, Protein from Caenorhabditis elegans)
- U2 snrna (56 kDa, RNA from Caenorhabditis elegans)
- Protein bud31 homolog (17 kDa, Protein from Caenorhabditis elegans)
- Uncharacterized protein t27f2.1 (60 kDa, Protein from Caenorhabditis elegans)
- Rrm domain-containing protein (24 kDa, Protein from Caenorhabditis elegans)
- Peptidyl-prolyl cis-trans isomerase e (36 kDa, Protein from Caenorhabditis elegans)
- Intron lariat spliceosome (Complex from Caenorhabditis elegans)
- Tpr_region domain-containing protein (88 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein e (10 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein-associated protein b (16 kDa, Protein from Caenorhabditis elegans)
- Zinc ion (65 Da, Ligand)
- Probable small nuclear ribonucleoprotein g (8 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Caenorhabditis elegans)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein f (9 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-processing factor 19 (53 kDa, Protein from Caenorhabditis elegans)
- Intron lariat rna (3 kDa, DNA from Caenorhabditis elegans)
- Pre-mrna-splicing factor syf-2 (27 kDa, Protein from Caenorhabditis elegans)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pre-mrna-splicing factor 8 homolog (272 kDa, Protein from Caenorhabditis elegans)
- Probable u2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Caenorhabditis elegans)
- Intron-binding protein aquarius (170 kDa, Protein from Caenorhabditis elegans)
- Inositol hexakisphosphate (660 Da, Ligand)
- Wd_repeats_region domain-containing protein (54 kDa, Protein from Caenorhabditis elegans)
- Wd_repeats_region domain-containing protein (36 kDa, Protein from Caenorhabditis elegans)
- Coiled-coil domain-containing protein 12 (19 kDa, Protein from Caenorhabditis elegans)
- Cell division cycle 5-like protein (85 kDa, Protein from Caenorhabditis elegans)
- Septin and tuftelin-interacting protein 1 homolog (94 kDa, Protein from Caenorhabditis elegans)
- Magnesium ion (24 Da, Ligand)
- Pre-mrna-splicing factor rbm22 (45 kDa, Protein from Caenorhabditis elegans)
- Small nuclear ribonucleoprotein sm d3 (14 kDa, Protein from Caenorhabditis elegans)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor syf1 (99 kDa, Protein from Caenorhabditis elegans)
- U6 snrna (32 kDa, RNA from Caenorhabditis elegans)
- Wd_repeats_region domain-containing protein (65 kDa, Protein from Caenorhabditis elegans)
- Peptidyl-prolyl cis-trans isomerase (18 kDa, Protein from Caenorhabditis elegans)
- Gcf c-terminal domain-containing protein (94 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor spf27 (27 kDa, Protein from Caenorhabditis elegans)
Structure of the C. elegans Intron Lariat Spliceosome double-primed for disassembly (ILS'')
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8ro1
Q-score: 0.373
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ DOI: doi:10.1038/s41586-024-07741-1 Pubmed: 38925148 ]
- Tr-type g domain-containing protein (110 kDa, Protein from Caenorhabditis elegans)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Caenorhabditis elegans)
- Intron lariat spliceosome (ils'') (Complex from Caenorhabditis elegans)
- Protein isy-1 (31 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor atp-dependent rna helicase ddx-15 (84 kDa, Protein from Caenorhabditis elegans)
- Intron lariat rna (10 kDa, RNA from Caenorhabditis elegans)
- Protein bud31 homolog (17 kDa, Protein from Caenorhabditis elegans)
- Uncharacterized protein t27f2.1 (60 kDa, Protein from Caenorhabditis elegans)
- Rrm domain-containing protein (24 kDa, Protein from Caenorhabditis elegans)
- Tpr_region domain-containing protein (88 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein e (10 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein-associated protein b (16 kDa, Protein from Caenorhabditis elegans)
- Zinc ion (65 Da, Ligand)
- Probable small nuclear ribonucleoprotein g (8 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein f (9 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-processing factor 19 (53 kDa, Protein from Caenorhabditis elegans)
- Replication stress response regulator sde2 (57 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor syf-2 (27 kDa, Protein from Caenorhabditis elegans)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pre-mrna-splicing factor 8 homolog (272 kDa, Protein from Caenorhabditis elegans)
- Peptidyl-prolyl cis-trans isomerase e (8 kDa, Protein from Caenorhabditis elegans)
- Probable u2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Caenorhabditis elegans)
- Intron-binding protein aquarius (170 kDa, Protein from Caenorhabditis elegans)
- Peptidyl-prolyl cis-trans isomerase (18 kDa, Protein from Caenorhabditis elegans)
- U2 snrna (68 kDa, RNA from Caenorhabditis elegans)
- Inositol hexakisphosphate (660 Da, Ligand)
- Wd_repeats_region domain-containing protein (54 kDa, Protein from Caenorhabditis elegans)
- Wd_repeats_region domain-containing protein (36 kDa, Protein from Caenorhabditis elegans)
- Cell division cycle 5-like protein (85 kDa, Protein from Caenorhabditis elegans)
- Septin and tuftelin-interacting protein 1 homolog (94 kDa, Protein from Caenorhabditis elegans)
- Magnesium ion (24 Da, Ligand)
- Pre-mrna-splicing factor rbm22 (45 kDa, Protein from Caenorhabditis elegans)
- Coiled-coil domain-containing protein 12 (8 kDa, Protein from Caenorhabditis elegans)
- Small nuclear ribonucleoprotein sm d3 (14 kDa, Protein from Caenorhabditis elegans)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor syf1 (99 kDa, Protein from Caenorhabditis elegans)
- U6 snrna (32 kDa, RNA from Caenorhabditis elegans)
- Wd_repeats_region domain-containing protein (65 kDa, Protein from Caenorhabditis elegans)
- Cwf19-like protein 2 homolog (53 kDa, Protein from Caenorhabditis elegans)
- Cwf19-like protein 1 homolog (59 kDa, Protein from Caenorhabditis elegans)
- Gcf c-terminal domain-containing protein (94 kDa, Protein from Caenorhabditis elegans)
- U5 snrna (35 kDa, RNA from Caenorhabditis elegans)
- Pre-mrna-splicing factor spf27 (27 kDa, Protein from Caenorhabditis elegans)
Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 2, Map 2)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8q7q
Q-score: 0.371
Riabov Bassat D, Visanpattanasin S, Vorlander MK, Fin L, Phillips AW, Plaschka C
Nat Struct Mol Biol (2024) 31 pp. 747-751 [ Pubmed: 38467876 DOI: doi:10.1038/s41594-024-01243-4 ]
- Cd2 antigen cytoplasmic tail-binding protein 2 (37 kDa, Protein from Homo sapiens)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- Structure of the recycling u5 snrnp bound to chaperones cd2bp2 and tssc4 (state , map 2) (1 MDa, Complex from Homo sapiens)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Protein tssc4 (34 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- Pre-mrna-processing factor 6 (107 kDa, Protein from Homo sapiens)
- U5 snrna (37 kDa, RNA from Homo sapiens)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 1, Map 1)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8q7v
Q-score: 0.252
Riabov Bassat D, Visanpattanasin S, Vorlander MK, Fin L, Phillips AW, Plaschka C
Nat Struct Mol Biol (2024) 31 pp. 747-751 [ Pubmed: 38467876 DOI: doi:10.1038/s41594-024-01243-4 ]
- Cd2 antigen cytoplasmic tail-binding protein 2 (37 kDa, Protein from Homo sapiens)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Protein tssc4 (34 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- Pre-mrna-processing factor 6 (107 kDa, Protein from Homo sapiens)
- U5 snrna (37 kDa, RNA from Homo sapiens)
- Structure of the recycling u5 snrnp bound to chaperones cd2bp2 and tssc4 (state 1, map 1) (1 MDa, Complex from Homo sapiens)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 3, Map 3)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8q7w
Q-score: 0.226
Riabov Bassat D, Visanpattanasin S, Vorlander MK, Fin L, Phillips AW, Plaschka C
Nat Struct Mol Biol (2024) 31 pp. 747-751 [ Pubmed: 38467876 DOI: doi:10.1038/s41594-024-01243-4 ]
- Cd2 antigen cytoplasmic tail-binding protein 2 (37 kDa, Protein from Homo sapiens)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Structure of the recycling u5 snrnp bound to chaperone cd2bp2 (state 3, map 3) (1 MDa, Complex from Homo sapiens)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- Pre-mrna-processing factor 6 (107 kDa, Protein from Homo sapiens)
- U5 snrna (37 kDa, RNA from Homo sapiens)
- Probable atp-dependent rna helicase ddx23 (95 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 4, Map 4)
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 8q7x
Q-score: 0.148
Riabov Bassat D, Visanpattanasin S, Vorlander MK, Fin L, Phillips AW, Plaschka C
Nat Struct Mol Biol (2024) 31 pp. 747-751 [ Pubmed: 38467876 DOI: doi:10.1038/s41594-024-01243-4 ]
- Structure of the recycling u5 snrnp bound to chaperone cd2bp2 (state 4, map 4) (1 MDa, Complex from Homo sapiens)
- Cd2 antigen cytoplasmic tail-binding protein 2 (37 kDa, Protein from Homo sapiens)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- Pre-mrna-processing factor 6 (107 kDa, Protein from Homo sapiens)
- U5 snrna (37 kDa, RNA from Homo sapiens)
- Probable atp-dependent rna helicase ddx23 (95 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
Structure of the human TREX core THO-UAP56 complex (map D)
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 7znl
Q-score: 0.069
Pacheco-Fiallos B, Vorlander MK, Riabov-Bassat D, Fin L, O'Reilly FJ, Ayala FI, Schellhaas U, Rappsilber J, Plaschka C
Nature (2023) 616 pp. 828-835 [ DOI: doi:10.1038/s41586-023-05904-0 Pubmed: 37020021 ]
- Tho-uap56 (1 MDa, Complex from Homo sapiens)
- Spliceosome rna helicase ddx39b (49 kDa, Protein from Homo sapiens)
- Tho complex subunit 3 (38 kDa, Protein from Homo sapiens)
- Tho complex subunit 5 homolog (78 kDa, Protein from Homo sapiens)
- Tho complex subunit 1 (75 kDa, Protein from Homo sapiens)
- Tho complex subunit 6 homolog (37 kDa, Protein from Homo sapiens)
- Tho complex subunit 7 homolog (23 kDa, Protein from Homo sapiens)
- Tho complex subunit 2 (183 kDa, Protein from Homo sapiens)
Structure of an endogenous human TREX complex bound to mRNA, composite map
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7znk
Q-score: 0.139
Pacheco-Fiallos B, Vorlander MK, Riabov-Bassat D, Fin L, O'Reilly FJ, Ayala FI, Schellhaas U, Rappsilber J, Plaschka C
Nature (2023) 616 pp. 828-835 [ DOI: doi:10.1038/s41586-023-05904-0 Pubmed: 37020021 ]
- Spliceosome rna helicase ddx39b (49 kDa, Protein from Homo sapiens)
- Tho complex subunit 3 (38 kDa, Protein from Homo sapiens)
- Tho complex subunit 4 (26 kDa, Protein from Homo sapiens)
- Tho complex subunit 1 (75 kDa, Protein from Homo sapiens)
- Endogenous human trex-mrna complex (1 MDa, Complex from Homo sapiens)
- Tho complex subunit 6 homolog (37 kDa, Protein from Homo sapiens)
- Tho complex subunit 7 homolog (23 kDa, Protein from Homo sapiens)
- Tho complex subunit 2 (183 kDa, Protein from Homo sapiens)
- Tho complex subunit 5 homolog (78 kDa, Protein from Homo sapiens)
- Rna (873 Da, RNA from Homo sapiens)
Structure of an ALYREF-exon junction complex hexamer
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7znj
Q-score: 0.608
Pacheco-Fiallos B, Vorlander MK, Riabov-Bassat D, Fin L, O'Reilly FJ, Ayala FI, Schellhaas U, Rappsilber J, Plaschka C
Nature (2023) 616 pp. 828-835 [ DOI: doi:10.1038/s41586-023-05904-0 Pubmed: 37020021 ]
- Hexameric complex between the trex subunit alyref and the exon junction complex (650 kDa, Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Rna (1 kDa, RNA from Homo sapiens)
- Eukaryotic initiation factor 4a-iii, n-terminally processed (43 kDa, Protein from Homo sapiens)
- Rna-binding protein 8a (10 kDa, Protein from Homo sapiens)
- Maltose/maltodextrin-binding periplasmic protein,tho complex subunit 4 (57 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Protein mago nashi homolog (17 kDa, Protein from Homo sapiens)