Cryo-EM structure of NLRP3 complex with Compound C
Resolution: 3.76 Å
EM Method: Single-particle
Fitted PDBs: 9dh3
Q-score: 0.348
Matico R, Grauwen K, Chauhan D, Yu X, Abdiaj I, Adhikary S, Adriaensen I, Aranzazu GM, Alcazar J, Bassi M, Brisse E, Canellas S, Chaudhuri S, Delgado F, Dieguez-Vazquez A, Du Jardin M, Eastham V, Finley M, Jacobs T, Keustermans K, Kuhn R, Llaveria J, Leenaerts J, Linares ML, Martin ML, Martin-Perez R, Martinez C, Miller R, Munoz FM, Muratore ME, Nooyens A, Perez-Benito L, Perrier M, Pietrak B, Serre J, Sharma S, Somers M, Suarez J, Tresadern G, Trabanco AA, Van den Bulck D, Van Gool M, Van Hauwermeiren F, Varghese T, Vega JA, Youssef SA, Edwards MJ, Oehlrich D, Van Opdenbosch N
Embo Mol Med (2025) 17 pp. 54-84 [ Pubmed: 39653810 DOI: doi:10.1038/s44321-024-00181-4 ]
- 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate (614 Da, Ligand)
- Maltose/maltodextrin-binding periplasmic protein,nacht, lrr and pyd domains-containing protein 3 chimera (142 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 2-[(4s)-5-ethyl-8-oxothieno[2',3':4,5]pyrrolo[1,2-d][1,2,4]triazin-7(8h)-yl]-n-(pyrimidin-4-yl)acetamide (354 Da, Ligand)
- N-terminal mbp fusion of nlrp3 lacking the pyd domain (Complex from Homo sapiens)
(CAG)2 DNA-bound MutSbeta in open form with kinked MSH2 clamp
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8rz7
Q-score: 0.292
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Mutsbeta-dna-adp complex (Complex)
- Dna mismatch repair protein (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna_2 (18 kDa, DNA from Homo sapiens)
- Dna_1 (20 kDa, DNA from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
- Double stranded dna (Complex from Homo sapiens)
MutSbeta-ATPgS with straight MSH2 clamp
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8rz8
Q-score: 0.349
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Mutsbeta-atpgs complex (Complex from Homo sapiens)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
MutSbeta-ATPgS with kinked MSH2 clamp
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8rz9
Q-score: 0.332
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Mutsbeta-atpgs complex (Complex from Homo sapiens)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)