Cryo-EM structure of the human BRISC dimer complex bound to compound FX-171-C
Chandler F, Reddy P, Bhutda S, Ross R, Walden M, Walker K, Cassel J, Prakesch M, Datti A, Campbell L, Foglizzo M, Bell L, Ault J, Al-awar R, Calabrese A, Sicheri F, Del Galdo F, Salvino J, Greenberg R, Zeqiraj E
To Be Published
- N-[(1r,5s)-3-azabicyclo[3.1.0]hexan-6-yl]-1-[2,6-bis(chloranyl)phenyl]carbonyl-4-[[2,6-bis(chloranyl)phenyl]carbonylamino]pyrazole-3-carboxamide (553 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Brisc dimer in complex with inhibitor fx-171-c (654 kDa, Complex from Homo sapiens)
- Brisc and brca1-a complex member 1 (29 kDa, Protein from Homo sapiens)
- Lys-63-specific deubiquitinase brcc36 (35 kDa, Protein from Homo sapiens)
- Brisc complex subunit abraxas 2 (31 kDa, Protein from Homo sapiens)
- Brisc and brca1-a complex member 2 (43 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human BRISC dimer complex bound to compound JMS-175-2
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8py2
Q-score: 0.281
Chandler F, Reddy P, Bhutda S, Ross R, Walden M, Walker K, Cassel J, Prakesch M, Campbell L, Foglizzo M, Bell L, Ault J, Al-awar R, Calabrese A, Sicheri F, Del Galdo F, Salvino J, Greenberg R, Zeqiraj E
To Be Published
- Brisc and brca1-a complex member 2 (43 kDa, Protein from Homo sapiens)
- Brisc dimer in complex with inhibitor jms-175-2 (654 kDa, Complex from Homo sapiens)
- Brisc and brca1-a complex member 1 (29 kDa, Protein from Homo sapiens)
- Lys-63-specific deubiquitinase brcc36 (36 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Brisc complex subunit abraxas 2 (31 kDa, Protein from Homo sapiens)
- 1-[2,6-bis(chloranyl)phenyl]carbonyl-4-[[2,6-bis(chloranyl)phenyl]carbonylamino]-n-piperidin-4-yl-pyrazole-3-carboxamide (555 Da, Ligand)
UFM1 ribosome E3 ligase complex bound to the 60S ribosomal subunit
Makhlouf L, Peter JJ, Magnussen HM, Thakur R, Millrine D, Minshull TC, Harrison G, Varghese J, Lamoliatte F, Foglizzo M, Macartney T, Calabrese AN, Zeqiraj E, Kulathu Y
Nature (2024) 627 pp. 437-444 [ DOI: 10.1038/s41586-024-07093-w Pubmed: 38383789 ]
Image sets:
Structure of the 55LCC ATPase complex
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 8rhn
Q-score: 0.361
Krishnamoorthy V, Foglizzo M, Dilley RL, Wu A, Datta A, Dutta P, Campbell LJ, Degtjarik O, Musgrove LJ, Calabrese AN, Zeqiraj E, Greenberg RA
Cell (2024) 187 pp. 2250- [ Pubmed: 38554706 DOI: doi:10.1016/j.cell.2024.03.002 ]
- Cdna flj55172 (29 kDa, Protein from Homo sapiens)
- Atpase family gene 2 protein homolog b (83 kDa, Protein from Homo sapiens)
- Cyclin-dependent kinase 2-interacting protein (27 kDa, Protein from Homo sapiens)
- Atpase family gene 2 protein homolog a (101 kDa, Protein from Homo sapiens)
- Structure of the 55lcc atpase complex (649 kDa, Complex from Homo sapiens)
UFL1 E3 ligase bound 60S ribosome
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8qfc
Q-score: 0.379
Makhlouf L, Peter JJ, Magnussen HM, Thakur R, Millrine D, Minshull TC, Harrison G, Varghese J, Lamoliatte F, Foglizzo M, Macartney T, Calabrese AN, Zeqiraj E, Kulathu Y
Nature (2024) 627 pp. 437-444 [ Pubmed: 38383789 DOI: doi:10.1038/s41586-024-07093-w ]
- E3 ufm1-protein ligase 1 (91 kDa, Protein from Homo sapiens)
- Ufm1 ribosome e3 ligase complex bound to 60s ribosome (Complex from Homo sapiens)
- Ddrgk domain-containing protein 1 (34 kDa, Protein from Homo sapiens)
- Cdk5 regulatory subunit-associated protein 3 (57 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l10a (24 kDa, Protein from Homo sapiens)
- Ubiquitin-fold modifier 1 (9 kDa, Protein from Homo sapiens)
UFL1 E3 ligase bound 60S ribosome
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 8qfd
Q-score: 0.684
Makhlouf L, Peter JJ, Magnussen HM, Thakur R, Millrine D, Minshull TC, Harrison G, Varghese J, Lamoliatte F, Foglizzo M, Macartney T, Calabrese AN, Zeqiraj E, Kulathu Y
Nature (2024) 627 pp. 437-444 [ Pubmed: 38383789 DOI: doi:10.1038/s41586-024-07093-w ]
- 60s ribosomal protein l39 (6 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l14 (23 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l35 (14 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l17 (21 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l7a (30 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l30 (12 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l27 (15 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l37a (10 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l11 (20 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l13a (23 kDa, Protein from Homo sapiens)
- 5s rrna (38 kDa, RNA from Homo sapiens)
- 60s ribosomal protein l27a (16 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l32 (15 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l10 (24 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l4 (47 kDa, Protein from Homo sapiens)
- E3 ufm1-protein ligase 1 (91 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l35a (12 kDa, Protein from Homo sapiens)
- Ufm1 ribosome e3 ligase complex (Complex from Homo sapiens)
- 60s ribosomal protein l28 (15 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l36 (12 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l31 (14 kDa, Protein from Homo sapiens)
- 60s ribosome bound by the ufm1 ribosome e3 ligase complex. (Complex from Homo sapiens)
- 60s ribosomal protein l6 (32 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l3 (46 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Large ribosomal subunit protein ul30 (29 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l36a (12 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l8 (28 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l18 (21 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l18a (20 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l19 (23 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l23a (17 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l29 (17 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l34 (13 kDa, Protein from Homo sapiens)
- Ribosomal protein l37 (11 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l38 (8 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l24 (17 kDa, Protein from Homo sapiens)
- 28s rrna (1 MDa, RNA from Homo sapiens)
- 60s ribosomal protein l5 (34 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l23 (14 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- 60s ribosomal protein l13 (24 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l26 (17 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l22 (14 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l21 (18 kDa, Protein from Homo sapiens)
- Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l15 (24 kDa, Protein from Homo sapiens)
- 5.8s rrna (50 kDa, RNA from Homo sapiens)
- 60s ribosomal protein l9 (21 kDa, Protein from Homo sapiens)
Structure of BARD1 ARD-BRCTs in complex with H2AKc15ub nucleosomes
Burdett H, Foglizzo M, Musgrove LJ, Kumar D, Clifford G, Campbell LJ, Heath GR, Zeqiraj E, Wilson MD
Nucleic Acids Res (2023) 51 pp. 11080-11103 [ Pubmed: 37823591 DOI: 10.1093/nar/gkad793 ]
Image sets:
Structure of BARD1 ARD-BRCTs in complex with H2AKc15ub nucleosomes (Map1)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8off
Q-score: 0.516
Burdett H, Foglizzo M, Musgrove LJ, Kumar D, Clifford G, Campbell LJ, Heath GR, Zeqiraj E, Wilson MD
Nucleic Acids Res (2023) 51 pp. 11080-11103 [ DOI: doi:10.1093/nar/gkad793 Pubmed: 37823591 ]
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Histone h2b type 1-c/e/f/g/i (13 kDa, Protein from Homo sapiens)
- Dna, histones and polyubiquitin-b (Complex from Homo sapiens)
- Brca1 associated ring domain 1 (Complex from Felis catus)
- Histone h3.1 (15 kDa, Protein from Homo sapiens)
- Bard1 ard-brcts in complex with h2akc15ub nucleosomes (246 kDa, Complex)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Histone h2a type 1 (14 kDa, Protein from Homo sapiens)
- Dna (142-mer) (108 kDa, DNA from Homo sapiens)
- Brca1 associated ring domain 1 (85 kDa, Protein from Felis catus)
Low-resolution structure of BRCA1dExon11-FL BARD1 (closed state)
Burdett H, Foglizzo M, Musgrove LJ, Kumar D, Clifford G, Campbell LJ, Heath GR, Zeqiraj E, Wilson MD
Nucleic Acids Res (2023) 51 pp. 11080-11103 [ DOI: doi:10.1093/nar/gkad793 Pubmed: 37823591 ]
- Heterodimeric complex of brca1dexon11 and fl bard1 (175 kDa, Complex from Felis catus)
Low-resolution structure of BRCA1dExon11-FL BARD1 (open state)
Burdett H, Foglizzo M, Musgrove LJ, Kumar D, Clifford G, Campbell LJ, Heath GR, Zeqiraj E, Wilson MD
Nucleic Acids Res (2023) 51 pp. 11080-11103 [ DOI: doi:10.1093/nar/gkad793 Pubmed: 37823591 ]
- Heterodimeric complex of brca1dexon11 and fl bard1 (175 kDa, Complex from Felis catus)