Cryo-EM structure of the human BRISC dimer complex bound to compound FX-171-C
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8pvy
Q-score: 0.332
Chandler F, Reddy P, Bhutda S, Ross R, Walden M, Walker K, Cassel J, Prakesch M, Datti A, Campbell L, Foglizzo M, Bell L, Ault J, Al-awar R, Calabrese A, Sicheri F, Del Galdo F, Salvino J, Greenberg R, Zeqiraj E
To Be Published
- Lys-63-specific deubiquitinase brcc36 (35 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- N-[(1r,5s)-3-azabicyclo[3.1.0]hexan-6-yl]-1-[2,6-bis(chloranyl)phenyl]carbonyl-4-[[2,6-bis(chloranyl)phenyl]carbonylamino]pyrazole-3-carboxamide (553 Da, Ligand)
- Brisc complex subunit abraxas 2 (31 kDa, Protein from Homo sapiens)
- Brisc and brca1-a complex member 2 (43 kDa, Protein from Homo sapiens)
- Brisc dimer in complex with inhibitor fx-171-c (654 kDa, Complex from Homo sapiens)
- Brisc and brca1-a complex member 1 (29 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human BRISC dimer complex bound to compound JMS-175-2
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8py2
Q-score: 0.281
Chandler F, Reddy P, Bhutda S, Ross R, Walden M, Walker K, Cassel J, Prakesch M, Campbell L, Foglizzo M, Bell L, Ault J, Al-awar R, Calabrese A, Sicheri F, Del Galdo F, Salvino J, Greenberg R, Zeqiraj E
To Be Published
- Zinc ion (65 Da, Ligand)
- Brisc dimer in complex with inhibitor jms-175-2 (654 kDa, Complex from Homo sapiens)
- 1-[2,6-bis(chloranyl)phenyl]carbonyl-4-[[2,6-bis(chloranyl)phenyl]carbonylamino]-n-piperidin-4-yl-pyrazole-3-carboxamide (555 Da, Ligand)
- Brisc complex subunit abraxas 2 (31 kDa, Protein from Homo sapiens)
- Brisc and brca1-a complex member 2 (43 kDa, Protein from Homo sapiens)
- Lys-63-specific deubiquitinase brcc36 (36 kDa, Protein from Homo sapiens)
- Brisc and brca1-a complex member 1 (29 kDa, Protein from Homo sapiens)
Structure of the 55LCC ATPase complex
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 8rhn
Q-score: 0.361
Krishnamoorthy V, Foglizzo M, Dilley RL, Wu A, Datta A, Dutta P, Campbell LJ, Degtjarik O, Musgrove LJ, Calabrese AN, Zeqiraj E, Greenberg RA
Cell (2024) 187 pp. 2250- [ DOI: doi:10.1016/j.cell.2024.03.002 Pubmed: 38554706 ]
- Cyclin-dependent kinase 2-interacting protein (27 kDa, Protein from Homo sapiens)
- Atpase family gene 2 protein homolog b (83 kDa, Protein from Homo sapiens)
- Cdna flj55172 (29 kDa, Protein from Homo sapiens)
- Structure of the 55lcc atpase complex (649 kDa, Complex from Homo sapiens)
- Atpase family gene 2 protein homolog a (101 kDa, Protein from Homo sapiens)
UFL1 E3 ligase bound 60S ribosome
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8qfc
Q-score: 0.379
Makhlouf L, Peter JJ, Magnussen HM, Thakur R, Millrine D, Minshull TC, Harrison G, Varghese J, Lamoliatte F, Foglizzo M, Macartney T, Calabrese AN, Zeqiraj E, Kulathu Y
Nature (2024) 627 pp. 437-444 [ DOI: doi:10.1038/s41586-024-07093-w Pubmed: 38383789 ]
- 60s ribosomal protein l10a (24 kDa, Protein from Homo sapiens)
- E3 ufm1-protein ligase 1 (91 kDa, Protein from Homo sapiens)
- Cdk5 regulatory subunit-associated protein 3 (57 kDa, Protein from Homo sapiens)
- Ddrgk domain-containing protein 1 (34 kDa, Protein from Homo sapiens)
- Ubiquitin-fold modifier 1 (9 kDa, Protein from Homo sapiens)
- Ufm1 ribosome e3 ligase complex bound to 60s ribosome (Complex from Homo sapiens)
UFL1 E3 ligase bound 60S ribosome
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 8qfd
Q-score: 0.684
Makhlouf L, Peter JJ, Magnussen HM, Thakur R, Millrine D, Minshull TC, Harrison G, Varghese J, Lamoliatte F, Foglizzo M, Macartney T, Calabrese AN, Zeqiraj E, Kulathu Y
Nature (2024) 627 pp. 437-444 [ DOI: doi:10.1038/s41586-024-07093-w Pubmed: 38383789 ]
- 60s ribosomal protein l21 (18 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l29 (17 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l3 (46 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l35 (14 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l35a (12 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l23 (14 kDa, Protein from Homo sapiens)
- 5s rrna (38 kDa, RNA from Homo sapiens)
- 60s ribosomal protein l28 (15 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l39 (6 kDa, Protein from Homo sapiens)
- 28s rrna (1 MDa, RNA from Homo sapiens)
- 60s ribosomal protein l38 (8 kDa, Protein from Homo sapiens)
- Ufm1 ribosome e3 ligase complex (Complex from Homo sapiens)
- 60s ribosomal protein l9 (21 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l36 (12 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l17 (21 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l8 (28 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l24 (17 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l15 (24 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l23a (17 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- 60s ribosomal protein l36a (12 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul30 (29 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l19 (23 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l5 (34 kDa, Protein from Homo sapiens)
- 60s ribosome bound by the ufm1 ribosome e3 ligase complex. (Complex from Homo sapiens)
- 60s ribosomal protein l10 (24 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l27a (16 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l30 (12 kDa, Protein from Homo sapiens)
- Ribosomal protein l37 (11 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- 60s ribosomal protein l27 (15 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l13a (23 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l11 (20 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l6 (32 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l34 (13 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l14 (23 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l4 (47 kDa, Protein from Homo sapiens)
- E3 ufm1-protein ligase 1 (91 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l31 (14 kDa, Protein from Homo sapiens)
- 5.8s rrna (50 kDa, RNA from Homo sapiens)
- 60s ribosomal protein l7a (30 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l22 (14 kDa, Protein from Homo sapiens)
- Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l13 (24 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l18 (21 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l18a (20 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l26 (17 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l32 (15 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l37a (10 kDa, Protein from Homo sapiens)
Structure of BARD1 ARD-BRCTs in complex with H2AKc15ub nucleosomes (Map1)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8off
Q-score: 0.516
Burdett H, Foglizzo M, Musgrove LJ, Kumar D, Clifford G, Campbell LJ, Heath GR, Zeqiraj E, Wilson MD
Nucleic Acids Res (2023) 51 pp. 11080-11103 [ Pubmed: 37823591 DOI: doi:10.1093/nar/gkad793 ]
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Histone h2a type 1 (14 kDa, Protein from Homo sapiens)
- Histone h3.1 (15 kDa, Protein from Homo sapiens)
- Bard1 ard-brcts in complex with h2akc15ub nucleosomes (246 kDa, Complex)
- Histone h2b type 1-c/e/f/g/i (13 kDa, Protein from Homo sapiens)
- Brca1 associated ring domain 1 (Complex from Felis catus)
- Dna (142-mer) (108 kDa, DNA from Homo sapiens)
- Brca1 associated ring domain 1 (85 kDa, Protein from Felis catus)
- Dna, histones and polyubiquitin-b (Complex from Homo sapiens)