Human transthyretin covalently modified with A2-derived stilbene in the canonical conformation
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8ve1
Q-score: 0.607
Basanta B, Nugroho K, Yan N, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen J, Forli S, Kelly JW, Lander GC
To Be Published
- Transthyretin (56 kDa, Complex from Homo sapiens)
- 3-(dimethylamino)-5-[(e)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid (311 Da, Ligand)
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Unliganded human transthyretin in the canonical conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ve2
Q-score: 0.485
Basanta B, Nugroho K, Yan N, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen J, Forli S, Kelly JW, Lander GC
To Be Published
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (55 kDa, Complex from Homo sapiens)
Unliganded human transthyretin in the compressed conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ve3
Q-score: 0.498
Basanta B, Nugroho K, Yan N, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen J, Forli S, Kelly JW, Lander GC
To Be Published
- Transthyretin (55 kDa, Complex from Homo sapiens)
- Transthyretin (13 kDa, Protein from Homo sapiens)
Unliganded human transthyretin in the frayed conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ve4
Q-score: 0.477
Basanta B, Nugroho K, Yan N, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen J, Forli S, Kelly JW, Lander GC
To Be Published
- Transthyretin (55 kDa, Complex from Homo sapiens)
- Transthyretin (13 kDa, Protein from Homo sapiens)
(Biarylamine-FT2-WT)1(C10A)3-human transthyretin in the compressed conformation
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ve5
Q-score: 0.489
Basanta B, Nugroho K, Yan N, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen J, Forli S, Kelly JW, Lander GC
To Be Published
- Transthyretin (57 kDa, Complex from Homo sapiens)
- Transthyretin (15 kDa, Protein from Homo sapiens)
- 2-[(3,5-dichloro-4-trioxidanylphenyl)amino]benzoic acid (330 Da, Ligand)
(Biarylamine-FT2-WT)1(C10A)3-human transthyretin in the frayed conformation
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8ve6
Q-score: 0.447
Basanta B, Nugroho K, Yan N, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen J, Forli S, Kelly JW, Lander GC
To Be Published
- Transthyretin (15 kDa, Protein from Homo sapiens)
- 2-[(3,5-dichloro-4-trioxidanylphenyl)amino]benzoic acid (330 Da, Ligand)
- Transthyretin (57 kDa, Complex from Homo sapiens)
Human transthyretin covalently modified with A2-derived stilbene in the compressed conformation
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8ve0
Q-score: 0.529
Basanta B, Nugroho K, Yan N, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen J, Forli S, Kelly JW, Lander GC
To Be Published
- 3-(dimethylamino)-5-[(e)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid (311 Da, Ligand)
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (56 kDa, Complex from Homo sapiens)
cryo-EM structure of human ATG9A in amphipols
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7jlo
Q-score: 0.536
Maeda S, Yamamoto H, Kinch LN, Garza CM, Takahashi S, Otomo C, Grishin NV, Forli S, Mizushima N, Otomo T
Nat Struct Mol Biol (2020) 27 pp. 1194-1201 [ DOI: doi:10.1038/s41594-020-00520-2 Pubmed: 33106659 ]
- Human atg9a in amphipols a8-35 (Cellular component from Homo sapiens)
- Autophagy-related protein 9a (66 kDa, Protein from Homo sapiens)
cryo-EM structure of human ATG9A in nanodiscs
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7jlp
Q-score: 0.552
Maeda S, Yamamoto H, Kinch LN, Garza CM, Takahashi S, Otomo C, Grishin NV, Forli S, Mizushima N, Otomo T
Nat Struct Mol Biol (2020) 27 pp. 1194-1201 [ DOI: doi:10.1038/s41594-020-00520-2 Pubmed: 33106659 ]
cryo-EM structure of human ATG9A in LMNG micelles
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7jlq
Q-score: 0.297
Maeda S, Yamamoto H, Kinch LN, Garza CM, Takahashi S, Otomo C, Grishin NV, Forli S, Mizushima N, Otomo T
Nat Struct Mol Biol (2020) 27 pp. 1194-1201 [ DOI: doi:10.1038/s41594-020-00520-2 Pubmed: 33106659 ]
- Human atg9a in lmng micelles (Cellular component from Homo sapiens)
- Autophagy-related protein 9a (66 kDa, Protein from Homo sapiens)