Human transthyretin covalently modified with A2-derived stilbene in the canonical conformation
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8ve1
Q-score: 0.607
Basanta B, Nugroho K, Yan N, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen J, Forli S, Kelly JW, Lander GC
To Be Published
- Transthyretin (56 kDa, Complex from Homo sapiens)
- 3-(dimethylamino)-5-[(e)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid (311 Da, Ligand)
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Structure of HIV cleaved synaptic complex (CSC) intasome bound with calcium
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6put
Q-score: 0.579
Passos DO, Li M, Jozwik IK, Zhao XZ, Santos-Martins D, Yang R, Smith SJ, Jeon Y, Forli S, Hughes SH, Burke Jr TR, Craigie R, Lyumkis D
Science (2020) 367 pp. 810-814 [ DOI: doi:10.1126/science.aay8015 Pubmed: 32001521 ]
- Zinc ion (65 Da, Ligand)
- Viral dna transferred strand (7 kDa, DNA from Human immunodeficiency virus 1)
- Assembly of hiv integrase and viral dna (400 kDa, Complex from Human immunodeficiency virus 1)
- Water (18 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Viral dna non-transferred strand (8 kDa, DNA from Human immunodeficiency virus 1)
- Chimeric sso7d and hiv-1 integrase (42 kDa, Protein from Human immunodeficiency virus 1)
Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and Bictegravir (BIC)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6puw
Q-score: 0.573
Passos DO, Li M, Jozwik IK, Zhao XZ, Santos-Martins D, Yang R, Smith SJ, Jeon Y, Forli S, Hughes SH, Burke Jr TR, Craigie R, Lyumkis D
Science (2020) 367 pp. 810-814 [ Pubmed: 32001521 DOI: doi:10.1126/science.aay8015 ]
- Chimeric sso7d and hiv-1 integrase (42 kDa, Protein from Human immunodeficiency virus 1)
- Viral dna non-transferred strand (8 kDa, DNA from Human immunodeficiency virus 1)
- Water (18 Da, Ligand)
- Assembly of hiv integrase and viral dna (400 kDa, Complex from hiv)
- Viral dna transferred strand (7 kDa, DNA from Human immunodeficiency virus 1)
- Magnesium ion (24 Da, Ligand)
- Bictegravir (449 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6puy
Q-score: 0.591
Passos DO, Li M, Jozwik IK, Zhao XZ, Santos-Martins D, Yang R, Smith SJ, Jeon Y, Forli S, Hughes SH, Burke Jr TR, Craigie R, Lyumkis D
Science (2020) 367 pp. 810-814 [ Pubmed: 32001521 DOI: doi:10.1126/science.aay8015 ]
- Chimeric sso7d and hiv-1 integrase (42 kDa, Protein from Human immunodeficiency virus 1)
- 4-amino-n-[(2,4-difluorophenyl)methyl]-1-hydroxy-6-(6-hydroxyhexyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide (446 Da, Ligand)
- Viral dna non-transferred strand (8 kDa, DNA from Human immunodeficiency virus 1)
- Assembly of hiv integrase and viral dna (400 kDa, Complex from Human immunodeficiency virus 1)
- Viral dna transferred strand (7 kDa, DNA from Human immunodeficiency virus 1)
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6puz
Q-score: 0.589
Passos DO, Li M, Jozwik IK, Zhao XZ, Santos-Martins D, Yang R, Smith SJ, Jeon Y, Forli S, Hughes SH, Burke Jr TR, Craigie R, Lyumkis D
Science (2020) 367 pp. 810-814 [ Pubmed: 32001521 DOI: doi:10.1126/science.aay8015 ]
- Chimeric sso7d and hiv-1 integrase (42 kDa, Protein from Human immunodeficiency virus 1)
- 4-azanyl-n-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-[2-(phenylsulfonyl)ethyl]-1,8-naphthyridine-3-carboxamide (514 Da, Ligand)
- Viral dna non-transferred strand (8 kDa, DNA from Human immunodeficiency virus 1)
- Assembly of hiv integrase and viral dna (400 kDa, Complex from hiv)
- Viral dna transferred strand (7 kDa, DNA from Human immunodeficiency virus 1)
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Zinc ion (65 Da, Ligand)