Structure of the Inmazeb cocktail and resistance to escape against Ebola virus
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7tn9
Q-score: 0.475
Rayaprolu V, Fulton BO, Rafique A, Arturo E, Williams D, Hariharan C, Callaway H, Parvate A, Schendel SL, Parekh D, Hui S, Shaffer K, Pascal KE, Wloga E, Giordano S, Negron N, Ni M, Copin R, Atwal GS, Franklin M, Boytz RM, Donahue C, Davey R, Baum A, Kyratsous CA, Saphire EO
Cell Host Microbe (2023) 31 pp. 260- [ Pubmed: 36708708 DOI: doi:10.1016/j.chom.2023.01.002 ]
- Regn3471 light chain (24 kDa, Protein from Mus musculus)
- Inmazeb therapeutic cocktail (Complex)
- Regn3470 heavy chain (23 kDa, Protein from Mus musculus)
- Regn3471 heavy chain (23 kDa, Protein from Mus musculus)
- Regn3470 light chain (23 kDa, Protein from Mus musculus)
- Regn3479 heavy chain (22 kDa, Protein from Mus musculus)
- Envelope glycoprotein, shed gp (Complex from Mus musculus)
- Gp2 (15 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Envelope glycoprotein (35 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Regn3471 heavy chain, regn3479 light chain, regn3471 light chain, regn3479 heavy chain, regn3470 heavy chain, regn3470 light chain (Complex from Ebola virus - Mayinga, Zaire, 1976)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Regn3479 light chain (23 kDa, Protein from Mus musculus)
Structure of interleukin receptor common gamma chain (IL2Rgamma) in complex with two antibodies
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8epa
Q-score: 0.433
Le Floc'h A, Nagashima K, Birchard D, Scott G, Ben LH, Ajithdoss D, Gayvert K, Romero Hernandez A, Herbin O, Tay A, Farrales P, Korgaonkar CK, Pan H, Shah S, Kamat V, Chatterjee I, Popke J, Oyejide A, Lim WK, Kim JH, Huang T, Franklin M, Olson W, Norton T, Perlee L, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM
Sci Transl Med (2023) 15 pp. eabo0205-eabo0205 [ Pubmed: 36630481 DOI: doi:10.1126/scitranslmed.abo0205 ]
- Regn9432 fab heavy chain (23 kDa, Protein from Mus musculus)
- Regn7257 fab heavy chain (23 kDa, Protein from Mus musculus)
- Cytokine receptor common subunit gamma (31 kDa, Protein from Homo sapiens)
- Complex of il2rgamma extracellular domain with fab fragments of antibodies regn7257 and regn9432 (Complex from Mus musculus)
- Regn7257 fab light chain (23 kDa, Protein from Mus musculus)
- Regn9432 fab light chain (23 kDa, Protein from Mus musculus)
Complex of SARS-CoV-2 receptor binding domain with the Fab fragments of two neutralizing antibodies
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6xdg
Q-score: 0.348
Hansen J, Baum A, Pascal KE, Russo V, Giordano S, Wloga E, Fulton BO, Yan Y, Koon K, Patel K, Chung KM, Hermann A, Ullman E, Cruz J, Rafique A, Huang T, Fairhurst J, Libertiny C, Malbec M, Lee WY, Welsh R, Farr G, Pennington S, Deshpande D, Cheng J, Watty A, Bouffard P, Babb R, Levenkova N, Chen C, Zhang B, Romero Hernandez A, Saotome K, Zhou Y, Franklin M, Sivapalasingam S, Lye DC, Weston S, Logue J, Haupt R, Frieman M, Chen G, Olson W, Murphy AJ, Stahl N, Yancopoulos GD, Kyratsous CA
Science (2020) 369 pp. 1010-1014 [ Pubmed: 32540901 DOI: doi:10.1126/science.abd0827 ]
- Spike protein s1 (28 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Regn10987 antibody fab fragment light chain (22 kDa, Protein from Homo sapiens)
- Regn10987 antibody fab fragment (Complex from Homo sapiens)
- Regn10987 antibody fab fragment heavy chain (24 kDa, Protein from Homo sapiens)
- Regn10933 antibody fab fragment heavy chain (24 kDa, Protein from Homo sapiens)
- Regn10933 antibody fab fragment light chain (23 kDa, Protein from Homo sapiens)
- Complex of sars-cov-2 spike protein receptor binding domain with fab fragments of two neutralizing antibodies (Complex)
- Spike protein receptor binding domain (Complex from Severe acute respiratory syndrome coronavirus 2)
- Regn10933 antibody fab fragment (Complex from Homo sapiens)