Structural basis of D9-THC analog activity at the Cannabinoid 1 receptor
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9erx
Q-score: 0.448
Gloriam D, Thorsen T, Kulkarni Y, Sykes D, Boggild A, Drace T, Hompluem P, Iliopoulos-Tsoutsouvas C, Nikas S, Daver H, Makriyannis A, Nissen P, Gajhede M, Veprintsev D, Boesen T, Kastrup J
Res Sq (2024) [ Pubmed: 38826401 DOI: doi:10.21203/rs.3.rs-4277209/v1 ]
- Antibody scfv16 fab fragment (32 kDa, Protein from Mus musculus)
- (6ar,10ar)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Hu210/cb1/gi1 signaling complex (Complex)
- Cannabinoid 1 receptor complexed with a g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cannabinoid receptor 1 (57 kDa, Protein from Homo sapiens)
- Antibody scfv16 (Complex from Mus musculus)
Bay Y, Venskutonyte R, Frantsen SM, Thorsen TS, Musgaard M, Frydenvang K, Francotte P, Pirotte B, Biggin PC, Kristensen AS, Boesen T, Pickering DS, Gajhede M, Kastrup JS
FEBS J (2024) 291 pp. 1506-1529 [ Pubmed: 38145505 DOI: doi:10.1111/febs.17046 ]
Ionotropic glutamate receptor K3 with glutamate and BPAM
Bay Y, Venskutonyte R, Frantsen SM, Thorsen TS, Musgaard M, Frydenvang K, Francotte P, Pirotte B, Biggin PC, Kristensen AS, Boesen T, Pickering DS, Gajhede M, Kastrup JS
FEBS J (2024) 291 pp. 1506-1529 [ Pubmed: 38145505 DOI: doi:10.1111/febs.17046 ]
PAPP-A dimer in complex with a dimer of the inhibitor STC2
Kobbero SD, Gajhede M, Mirza OA, Kloverpris S, Kjaer TR, Mikkelsen JH, Boesen T, Oxvig C
Nat Commun (2022) 13 pp. 6084-6084 [ DOI: doi:10.1038/s41467-022-33698-8 Pubmed: 36257932 ]
- Papp-a (Protein from Homo sapiens)
- Papp-a (Complex from Homo sapiens)
- Stc2 (Protein from Homo sapiens)
- Papp-a dimer in complex with its endogenous inhibitor stc2 dimer (400 kDa, Complex)
- Stanniocalcin-2 (Complex from Homo sapiens)
PAPP-A dimer in complex with endogenous STC2 inhibitor.
Kobbero SD, Gajhede M, Mirza OA, Kloverpris S, Kjaer TR, Mikkelsen JH, Boesen T, Oxvig C
Nat Commun (2022) 13 pp. 6084-6084 [ DOI: doi:10.1038/s41467-022-33698-8 Pubmed: 36257932 ]
- Papp-a (Protein from Homo sapiens)
- Stanniocalcin 2 (Protein from Homo sapiens)
- Pregnancy-associated plasma protein a (Complex from Homo sapiens)
- Papp-a dimer in complex with its endogenous inhibitor stc2 dimer (100 kDa, Complex)
- Stanniocalcin-2 (Complex from Homo sapiens)
Partial dimer complex of PAPP-A and its inhibitor STC2
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8a7d
Q-score: 0.457
Kobbero SD, Gajhede M, Mirza OA, Kloverpris S, Kjaer TR, Mikkelsen JH, Boesen T, Oxvig C
Nat Commun (2022) 13 pp. 6084-6084 [ DOI: doi:10.1038/s41467-022-33698-8 Pubmed: 36257932 ]
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- C-terminal part of papp-a (Complex from Homo sapiens)
- Pappalysin-1 (171 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Papp-a (Complex from Homo sapiens)
- Stanniocalcin-2 (18 kDa, Protein from Homo sapiens)
- Partial papp-a dimer in complex with subunit of its endogenous inhibitor stc2 dimer (500 kDa, Complex from Homo sapiens)
- N-terminal part of papp-a (Complex from Homo sapiens)
- Subunit of stanniocalcin-2 (Complex from Homo sapiens)
PAPP-A dimer in complex with its inhibitor STC2 (CASP target)
Resolution: 5.02 Å
EM Method: Single-particle
Fitted PDBs: 8a7e
Q-score: 0.147
Kobbero SD, Gajhede M, Mirza OA, Kloverpris S, Kjaer TR, Mikkelsen JH, Boesen T, Oxvig C
Nat Commun (2022) 13 pp. 6084-6084 [ DOI: doi:10.1038/s41467-022-33698-8 Pubmed: 36257932 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Pappalysin-1 (171 kDa, Protein from Homo sapiens)
- Pregnancy-associated plasma protein a (Complex from Homo sapiens)
- Stanniocalcin-2 (18 kDa, Protein from Homo sapiens)
- Papp-a dimer in complex with its endogenous inhibitor stc2 dimer (100 kDa, Complex from Homo sapiens)
- Stanniocalcin-2 (Complex from Homo sapiens)
Density map of GluA2cryst with agonist AMPA, Class 1, compact
Krintel C, Dorosz J, Larsen AH, Thorsen TS, Venskutonyte R, Mirza O, Gajhede M, Boesen T, Kastrup JS
FEBS J (2021) 288 pp. 995-1007 [ DOI: doi:10.1111/febs.15455 Pubmed: 32543078 ]
- Glua2cryst with agonist ampa (370 kDa, Complex from Rattus norvegicus)
Density map of GluA2cryst in the apo state
Krintel C, Dorosz J, Larsen AH, Thorsen TS, Venskutonyte R, Mirza O, Gajhede M, Boesen T, Kastrup JS
FEBS J (2021) 288 pp. 995-1007 [ DOI: doi:10.1111/febs.15455 Pubmed: 32543078 ]
- Glua2cryst in the apo state (370 kDa, Complex from Rattus norvegicus)
Krintel C, Dorosz J, Larsen AH, Thorsen TS, Venskutonyte R, Mirza O, Gajhede M, Boesen T, Kastrup JS
FEBS J (2021) 288 pp. 995-1007 [ DOI: doi:10.1111/febs.15455 Pubmed: 32543078 ]