Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with S1P
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 7vie
Q-score: 0.537
Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R
PNAS (2022) 119 pp. e2117716119-e2117716119 [ DOI: doi:10.1073/pnas.2117716119 Pubmed: 35412894 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- (2s,3r,4e)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (379 Da, Ligand)
- Scfv16 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- S1pr1/gi complex with s1p (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Sphingosine 1-phosphate receptor 1 (44 kDa, Protein from Homo sapiens)
- S1pr1/gi (Complex from Mus musculus)
Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with (S)-FTY720-P
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 7vif
Q-score: 0.553
Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R
PNAS (2022) 119 pp. e2117716119-e2117716119 [ DOI: doi:10.1073/pnas.2117716119 Pubmed: 35412894 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- S1pr1/gi complex with fty720p (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Sphingosine 1-phosphate receptor 1 (44 kDa, Protein from Homo sapiens)
- (2~{s})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol (387 Da, Ligand)
- S1pr1/gi (Complex from Mus musculus)
Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 7vig
Q-score: 0.563
Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R
PNAS (2022) 119 pp. e2117716119-e2117716119 [ DOI: doi:10.1073/pnas.2117716119 Pubmed: 35412894 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- S1pr1/gi complex with cbp-307 (Complex from Homo sapiens)
- Scfv16 (Complex)
- 1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid (409 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Sphingosine 1-phosphate receptor 1 (44 kDa, Protein from Homo sapiens)
- S1pr1/gi (Complex from Mus musculus)
Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 7vih
Q-score: 0.521
Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R
PNAS (2022) 119 pp. e2117716119-e2117716119 [ DOI: doi:10.1073/pnas.2117716119 Pubmed: 35412894 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- S1pr1/gi complex with cbp-307 (Complex from Homo sapiens)
- Scfv16 (Complex)
- 1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid (409 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Sphingosine 1-phosphate receptor 1 (44 kDa, Protein from Homo sapiens)
- S1pr1/gi (Complex from Mus musculus)