Human NEXT dimer - overall reconstruction of the core complex
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7z4y
Q-score: 0.257
Gerlach P, Garland W, Lingaraju M, Salerno-Kochan A, Bonneau F, Basquin J, Jensen TH, Conti E
Mol Cell (2022) 82 pp. 2505- [ Pubmed: 35688157 DOI: doi:10.1016/j.molcel.2022.04.011 ]
Human NEXT dimer - focused reconstruction of the dimerization module
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7z4z
Q-score: 0.392
Gerlach P, Garland W, Lingaraju M, Salerno-Kochan A, Bonneau F, Basquin J, Jensen TH, Conti E
Mol Cell (2022) 82 pp. 2505- [ Pubmed: 35688157 DOI: doi:10.1016/j.molcel.2022.04.011 ]
Human NEXT dimer - focused reconstruction of the single MTR4
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7z52
Q-score: 0.512
Gerlach P, Garland W, Lingaraju M, Salerno-Kochan A, Bonneau F, Basquin J, Jensen TH, Conti E
Mol Cell (2022) 82 pp. 2505- [ Pubmed: 35688157 DOI: doi:10.1016/j.molcel.2022.04.011 ]
- Zinc finger cchc domain-containing protein 8 (78 kDa, Protein from Homo sapiens)
- Exosome rna helicase mtr4 (118 kDa, Protein from Homo sapiens)
- Human next dimer - focused reconstruction of the single mtr4 (Complex from Homo sapiens)
- Rna (5'-r(p*up*up*up*up*u)-3') (1 kDa, RNA from synthetic construct)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
Human NEXT dimer - single protomer
Gerlach P, Garland W, Lingaraju M, Salerno-Kochan A, Bonneau F, Basquin J, Jensen TH, Conti E
Mol Cell (2022) 82 pp. 2505-2518.e7 [ Pubmed: 35688157 DOI: doi:10.1016/j.molcel.2022.04.011 ]
- Human next dimer - single protomer (Complex from Homo sapiens)
- Human next dimer - single protomer (Complex)
- Rna 5prime hairpin u60 (RNA from synthetic construct)
- Rna-binding protein 7 (Protein from Homo sapiens)
- Zinc finger cchc domain-containing protein 8 (Protein from Homo sapiens)
- Exosome rna helicase mtr4 (Protein from Homo sapiens)
- Rna 5prime hairpin u60 (Complex from synthetic construct)
Human NEXT dimer in complex with the nuclear RNA exosome
Gerlach P, Garland W, Lingaraju M, Salerno-Kochan A, Bonneau F, Basquin J, Jensen TH, Conti E
Mol Cell (2022) 82 pp. 2505-2518.e7 [ Pubmed: 35688157 DOI: doi:10.1016/j.molcel.2022.04.011 ]
- Exosome complex component rrp45 (Protein from Homo sapiens)
- Rna 5 prime hairpin u60 (Complex from synthetic construct)
- Human next dimer in complex with the nuclear rna exosome (Complex)
- Human next dimer in complex with the nuclear rna exosome (Complex from Homo sapiens)
- Exosome complex component rrp4 (Protein from Homo sapiens)
- Rna-binding protein 7 (Protein from Homo sapiens)
- M-phase phosphoprotein 6 (Protein from Homo sapiens)
- Rna 5 prime hairpin u60 (RNA from synthetic construct)
- Nuclear nucleic acid-binding protein c1d (Protein from Homo sapiens)
- Exosome complex exonuclease rrp44 (Protein from Homo sapiens)
- Exosome complex component rrp46 (Protein from Homo sapiens)
- Exosome rna helicase mtr4 (Protein from Homo sapiens)
- Exosome complex component rrp41 (Protein from Homo sapiens)
- Exosome complex component rrp40 (Protein from Homo sapiens)
- Zinc finger cchc domain-containing protein 8 (Protein from Homo sapiens)
- Exosome complex component mtr3 (Protein from Homo sapiens)
- Exosome component 10 (Protein from Homo sapiens)
- Exosome complex component csl4 (Protein from Homo sapiens)
- Exosome complex component rrp42 (Protein from Homo sapiens)