Cryo-EM structure of the HIV-1 JR-FL IDL Env trimer in complex with PGT122 Fab
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 9ber
Q-score: 0.327
Zhang P, Gorman J, Tsybovsky Y, Lu M, Liu Q, Gopan V, Singh M, Lin Y, Miao H, Seo Y, Kwon A, Olia AS, Chuang GY, Geng H, Lai YT, Zhou T, Mascola JR, Mothes W, Kwong PD, Lusso P
Cell Rep (2024) 43 pp. 114518-114518 [ Pubmed: 39028623 DOI: doi:10.1016/j.celrep.2024.114518 ]
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of the hiv-1 jr-fl idl env trimer in complex with pgt122 fab (Complex from Human immunodeficiency virus 1)
- Sulfate ion (96 Da, Ligand)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Pgt122 light chain (11 kDa, Protein from Homo sapiens)
- Pgt122 heavy chain (14 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the HIV-1 BG505 IDL Env trimer in complex with 3BNC117 and 10-1074 Fabs
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9bew
Q-score: 0.488
Zhang P, Gorman J, Tsybovsky Y, Lu M, Liu Q, Gopan V, Singh M, Lin Y, Miao H, Seo Y, Kwon A, Olia AS, Chuang GY, Geng H, Lai YT, Zhou T, Mascola JR, Mothes W, Kwong PD, Lusso P
Cell Rep (2024) 43 pp. 114518-114518 [ Pubmed: 39028623 DOI: doi:10.1016/j.celrep.2024.114518 ]
- 3bnc117 heavy chain (24 kDa, Protein from Homo sapiens)
- 10-1074 light chain (23 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 10-1074 heavy chain (25 kDa, Protein from Homo sapiens)
- 3bnc117 light chain (23 kDa, Protein from Homo sapiens)
- Cryo-em structure of the hiv-1 bg505 idl env trimer in complex with 3bnc117 and 10-1074 fabs (Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the HIV-1 WITO IDL Env trimer in complex with PGT122 Fab
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 9bf6
Q-score: 0.241
Zhang P, Gorman J, Tsybovsky Y, Lu M, Liu Q, Gopan V, Singh M, Lin Y, Miao H, Seo Y, Kwon A, Olia AS, Chuang GY, Geng H, Lai YT, Zhou T, Mascola JR, Mothes W, Kwong PD, Lusso P
Cell Rep (2024) 43 pp. 114518-114518 [ Pubmed: 39028623 DOI: doi:10.1016/j.celrep.2024.114518 ]
- Phosphate ion (94 Da, Ligand)
- Cryo-em structure of the hiv-1 wito idl env trimer in complex with pgt122 fab (Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pgt122 light chain (11 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Pgt122 heavy chain (14 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
Cryo-EM Structure of CAP256-VRC26.25 Fab bound to HIV-1 Env trimer CAP256.wk34.c80 SOSIP.RnS2
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6vtt
Q-score: 0.445
Gorman J, Chuang GY, Lai YT, Shen CH, Boyington JC, Druz A, Geng H, Louder MK, McKee K, Rawi R, Verardi R, Yang Y, Zhang B, Doria-Rose NA, Lin B, Moore PL, Morris L, Shapiro L, Mascola JR, Kwong PD
Cell Rep (2020) 31 pp. 107488-107488 [ Pubmed: 32268107 DOI: doi:10.1016/j.celrep.2020.03.052 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vrc26.25 light chain (23 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Vrc26.25 heavy chain (28 kDa, Protein from Homo sapiens)
- Cap256-vrc26.25 fab (Complex from Homo sapiens)
- Cryo-em structure of cap256-vrc26.25 fab bound to hiv-1 env trimer cap256.wk34.c80 sosip.rns2 (Complex)
- Hiv-1 env trimer cap256.wk34.c80 sosip.rns2 (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
Cryo-EM structure of stabilized HIV-1 Env trimer CAP256.wk34.c80 SOSIP.RnS2
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 6vrw
Q-score: 0.46
Gorman J, Chuang GY, Lai YT, Shen CH, Boyington JC, Druz A, Geng H, Louder MK, McKee K, Rawi R, Verardi R, Yang Y, Zhang B, Doria-Rose NA, Lin B, Moore PL, Morris L, Shapiro L, Mascola JR, Kwong PD
Cell Rep (2020) 31 pp. 107488-107488 [ Pubmed: 32268107 DOI: doi:10.1016/j.celrep.2020.03.052 ]
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv-1 env trimer cap256 su.wk34.80 sosip.rns2 (Complex from Human immunodeficiency virus 1)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6cde
Q-score: 0.443
Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill KR, Jafari AJ, Kwon YD, Lai YT, Lemmin T, McKee K, Ohr TY, Ou L, Peng D, Rowshan AP, Sheng Z, Todd JP, Tsybovsky Y, Viox EG, Wang Y, Wei H, Yang Y, Zhou AF, Chen R, Yang L, Scorpio DG, McDermott AB, Shapiro L, Carragher B, Potter CS, Mascola JR, Kwong PD
Nat Med (2018) 24 pp. 857-867 [ Pubmed: 29867235 DOI: doi:10.1038/s41591-018-0042-6 ]
- Vfp20.01 light chain (23 kDa, Protein from Homo sapiens)
- Vrc03 heavy chain (24 kDa, Protein from Homo sapiens)
- Vrc03 light chain (23 kDa, Protein from Homo sapiens)
- Alpha-d-mannopyranose (180 Da, Ligand)
- Glycoprotein 41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Pgt122 light chain (22 kDa, Protein from Homo sapiens)
- Vfp20.01-bg505 ds-sosip-vrc03-pgt122 (Complex)
- Vfp20.01 heavy chain (22 kDa, Protein from Homo sapiens)
- Glycoprotein 120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Pgt122 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein (Complex from Human immunodeficiency virus 1)
- Vfp20.01 (Complex from Homo sapiens)
- Pgt122 heavy chain (24 kDa, Protein from Homo sapiens)
- Vrc03 (Complex from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6cdi
Q-score: 0.432
Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill KR, Jafari AJ, Kwon YD, Lai YT, Lemmin T, McKee K, Ohr TY, Ou L, Peng D, Rowshan AP, Sheng Z, Todd JP, Tsybovsky Y, Viox EG, Wang Y, Wei H, Yang Y, Zhou AF, Chen R, Yang L, Scorpio DG, McDermott AB, Shapiro L, Carragher B, Potter CS, Mascola JR, Kwong PD
Nat Med (2018) 24 pp. 857-867 [ Pubmed: 29867235 DOI: doi:10.1038/s41591-018-0042-6 ]
- Pgt122 light chain (11 kDa, Protein from Homo sapiens)
- Vfp16.02 heavy chain (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pgt122 heavy chain (14 kDa, Protein from Homo sapiens)
- Vrc03 light chain (11 kDa, Protein from Homo sapiens)
- Vfp20.01-bg505 ds-sosip-vrc03-pgt122 (Complex)
- Glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Vfp16.02 (Complex from Homo sapiens)
- Glycoprotein 120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Pgt122 (Complex from Homo sapiens)
- Vfp16.02 light chain (23 kDa, Protein from Homo sapiens)
- Glycoprotein (Complex from Human immunodeficiency virus 1)
- Vrc03 heavy chain (24 kDa, Protein from Homo sapiens)
- Vrc03 (Complex from Homo sapiens)
Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill KR, Jafari AJ, Kwon YD, Lai YT, Lemmin T, McKee K, Ohr TY, Ou L, Peng D, Rowshan AP, Sheng Z, Todd JP, Tsybovsky Y, Viox EG, Wang Y, Wei H, Yang Y, Zhou AF, Chen R, Yang L, Scorpio DG, McDermott AB, Shapiro L, Carragher B, Potter CS, Mascola JR, Kwong PD
Nat Med (2018) 24 pp. 857-867 [ Pubmed: 29867235 DOI: doi:10.1038/s41591-018-0042-6 ]
- Bg505 ds-sosip (Protein from Human immunodeficiency virus 1)
- Hiv-1 env trimer in complex with antibody (Complex from Human immunodeficiency virus 1)
- Vfp1.01 light chain (Protein from Homo sapiens)
- Hiv-1 env trimer (Complex from Human immunodeficiency virus 1)
- Vfp1.01 heavy chain (Protein from Homo sapiens)
Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill KR, Jafari AJ, Kwon YD, Lai YT, Lemmin T, McKee K, Ohr TY, Ou L, Peng D, Rowshan AP, Sheng Z, Todd JP, Tsybovsky Y, Viox EG, Wang Y, Wei H, Yang Y, Zhou AF, Chen R, Yang L, Scorpio DG, McDermott AB, Shapiro L, Carragher B, Potter CS, Mascola JR, Kwong PD
Nat Med (2018) 24 pp. 857-867 [ Pubmed: 29867235 DOI: doi:10.1038/s41591-018-0042-6 ]
Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill KR, Jafari AJ, Kwon YD, Lai YT, Lemmin T, McKee K, Ohr TY, Ou L, Peng D, Rowshan AP, Sheng Z, Todd JP, Tsybovsky Y, Viox EG, Wang Y, Wei H, Yang Y, Zhou AF, Chen R, Yang L, Scorpio DG, McDermott AB, Shapiro L, Carragher B, Potter CS, Mascola JR, Kwong PD
Nat Med (2018) 24 pp. 857-867 [ Pubmed: 29867235 DOI: doi:10.1038/s41591-018-0042-6 ]