X. laevis CMG dimer bound to dimeric DONSON - without ATPase
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8q6o
Q-score: 0.471
Cvetkovic MA, Passaretti P, Butryn A, Reynolds-Winczura A, Kingsley G, Skagia A, Fernandez-Cuesta C, Poovathumkadavil D, George R, Chauhan AS, Jhujh SS, Stewart GS, Gambus A, Costa A
Mol Cell (2023) 83 pp. 4017- [ Pubmed: 37820732 DOI: doi:10.1016/j.molcel.2023.09.029 ]
- Zinc ion (65 Da, Ligand)
- Dna replication complex gins protein psf1 (23 kDa, Protein from Xenopus laevis)
- Dna replication licensing factor mcm5-a (82 kDa, Protein from Xenopus laevis)
- Dna replication licensing factor mcm2 (100 kDa, Protein from Xenopus laevis)
- Dna replication licensing factor mcm4-b (97 kDa, Protein from Xenopus laevis)
- Maternal dna replication licensing factor mcm6 (92 kDa, Protein from Xenopus laevis)
- Dna replication complex gins protein psf3 (23 kDa, Protein from Xenopus laevis)
- Dna replication complex gins protein psf2 (21 kDa, Protein from Xenopus laevis)
- Maternal dna replication licensing factor mcm3 (90 kDa, Protein from Xenopus laevis)
- Protein downstream neighbor of son homolog (63 kDa, Protein from Xenopus laevis)
- X. laevis cmg dimer bound to dimeric donson (1 MDa, Complex from Xenopus laevis)
- Dna replication licensing factor mcm7-b (81 kDa, Protein from Xenopus laevis)
- Cell division control protein 45 homolog (65 kDa, Protein from Xenopus laevis)
- Dna replication complex gins protein sld5 (25 kDa, Protein from Xenopus laevis)
X. laevis CMG dimer bound to dimeric DONSON - MCM ATPase
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 8q6p
Q-score: 0.369
Cvetkovic MA, Passaretti P, Butryn A, Reynolds-Winczura A, Kingsley G, Skagia A, Fernandez-Cuesta C, Poovathumkadavil D, George R, Chauhan AS, Jhujh SS, Stewart GS, Gambus A, Costa A
Mol Cell (2023) 83 pp. 4017- [ Pubmed: 37820732 DOI: doi:10.1016/j.molcel.2023.09.029 ]
- Dna replication licensing factor mcm5-a (82 kDa, Protein from Xenopus laevis)
- Dna replication licensing factor mcm2 (100 kDa, Protein from Xenopus laevis)
- Dna replication licensing factor mcm4-b (97 kDa, Protein from Xenopus laevis)
- Maternal dna replication licensing factor mcm6 (92 kDa, Protein from Xenopus laevis)
- Maternal dna replication licensing factor mcm3 (90 kDa, Protein from Xenopus laevis)
- Protein downstream neighbor of son homolog (63 kDa, Protein from Xenopus laevis)
- X. laevis cmg dimer bound to dimeric donson (1 MDa, Complex from Xenopus laevis)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna replication licensing factor mcm7-b (81 kDa, Protein from Xenopus laevis)
Single CMG purified from replicating Xenopus egg extracts
Cvetkovic MA, Passaretti P, Butryn A, Reynolds-Winczura A, Kingsley G, Skagia A, Fernandez-Cuesta C, Poovathumkadavil D, George R, Chauhan AS, Jhujh SS, Stewart GS, Gambus A, Costa A
Mol Cell (2023) 83 pp. 4017-4031.e9 [ Pubmed: 37820732 DOI: doi:10.1016/j.molcel.2023.09.029 ]
- Dna replication licensing factor mcm4 - xenopus laevis (Protein from Xenopus laevis)
- Single cmg purified from replicating xenopus egg extracts (700 kDa, Complex from Xenopus laevis)
- Dna replication complex gins protein psf3 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication complex gins protein sld5 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication complex gins protein psf1 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication licensing factor mcm2 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication licensing factor mcm5 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication licensing factor mcm3 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication complex gins protein psf2 - xenopus laevis (Protein from Xenopus laevis)
- Cell division control protein 45 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication licensing factor mcm6 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication licensing factor mcm7 - xenopus laevis (Protein from Xenopus laevis)
Cryo-EM structure of the Human BRISC-SHMT2 complex
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6r8f
Q-score: 0.451
Walden M, Tian L, Ross RL, Sykora UM, Byrne DP, Hesketh EL, Masandi SK, Cassel J, George R, Ault JR, El Oualid F, Pawlowski K, Salvino JM, Eyers PA, Ranson NA, Del Galdo F, Greenberg RA, Zeqiraj E
Nature (2019) 570 pp. 194-199 [ DOI: doi:10.1038/s41586-019-1232-1 Pubmed: 31142841 ]
- Serine hydroxymethyltransferase, mitochondrial (56 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Serine hydroxymethyltransferase, mitochondrial (Complex from Homo sapiens)
- Brisc-shmt2 (388 MDa, Complex)
- Brisc and brca1-a complex member 2,brcc45 (bre, brisc and brca1-a complex member 2) (22 kDa, Protein from Homo sapiens)
- Merit40 (brisc and brca1-a complex member 1) (Complex from Homo sapiens)
- Brisc complex subunit abraxas 2 (31 kDa, Protein from Homo sapiens)
- Lys-63-specific deubiquitinase brcc36 (36 kDa, Protein from Homo sapiens)
Cryo-EM structure of the Human BRISC-SHMT2 complex, C2 reconstruction
Walden M, Tian L, Ross RL, Sykora UM, Byrne DP, Hesketh EL, Masandi SK, Cassel J, George R, Ault JR, El Oualid F, Pawlowski K, Salvino JM, Eyers PA, Ranson NA, Del Galdo F, Greenberg RA, Zeqiraj E
Nature (2019) 570 pp. 194-199 [ DOI: doi:10.1038/s41586-019-1232-1 Pubmed: 31142841 ]
- Merit40 (babam1) (Protein from Homo sapiens)
- Brcc45 (bre) (Protein from Homo sapiens)
- Brisc-shmt2 (388 MDa, Complex from Homo sapiens)
- Shmt2 (Protein from Homo sapiens)
- Brcc36 (Protein from Homo sapiens)
- Abraxas2 (Protein from Homo sapiens)
Structure of the RET receptor tyrosine kinase extracellular domain
Resolution: 24.0 Å
EM Method: Single-particle
Fitted PDBs: 4ux8
Q-score: 0.062
Goodman K, Kjaer S, Beuron F, Knowles P, Nawrotek A, Burns E, Purkiss A, George R, Santoro M, Morris EP, McDonald NQ
Cell Rep (2014) 8 pp. 1894-1904 [ DOI: doi:10.1016/j.celrep.2014.08.040 Pubmed: 25242331 ]
- Reconstituted mammalian retecd-gdnf-gfra1 ternary complex (340 kDa, Sample)
- Glial-cell-line-derived neurotrophic factor (10 kDa, Protein from Homo sapiens)
- Gdnf receptor alpha (40 kDa, Protein from Rattus norvegicus)
- Ret receptor tyrosine kinase (80 kDa, Protein from Homo sapiens)
Structure of the zebrafish RET tyrosine kinase extracellular domain
Goodman K, Kjaer S, Beuron F, Knowles P, Nawrotek A, Burns E, Purkiss A, George R, Santoro M, Morris EP, McDonald NQ
Cell Rep (2014) 8 pp. 1894-1904 [ DOI: doi:10.1016/j.celrep.2014.08.040 Pubmed: 25242331 ]
- Gdnf receptor alpha (Protein from Danio rerio)
- Glial-cell-line-derived neurotrophic factor (Protein from Danio rerio)
- Ret receptor tyrosine kinase (83 kDa, Protein from Danio rerio)
- Reconstituted zebrafish retecd-gdnf-gfra1 ternary complex (240 kDa, Sample)