Progesterone-bound DB3 Fab in complex with computationally designed DBPro1156_2 protein binder
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9fkd
Q-score: 0.488
Marchand A, Buckley S, Schneuing A, Pacesa M, Elia M, Gainza P, Elizarova E, Neeser RM, Lee PW, Reymond L, Miao Y, Scheller L, Georgeon S, Schmidt J, Schwaller P, Maerkl SJ, Bronstein M, Correia BE
Nature (2025) [ Pubmed: 39814890 DOI: doi:10.1038/s41586-024-08435-4 ]
- Db3 fab heavy chain (25 kDa, Protein from synthetic construct)
- Progesterone-bound db3 fab in complex with computationally designed dbpro1156_2 protein binder (107 kDa, Complex from synthetic construct)
- Anti-kappa fab heavy chain (25 kDa, Protein from synthetic construct)
- De novo designed dbpro1156_2 binder (8 kDa, Protein from synthetic construct)
- Progesterone (314 Da, Ligand)
- Anti-kappa fab light chain (24 kDa, Protein from synthetic construct)
- Db3 fab light chain (24 kDa, Protein from synthetic construct)
cryo-EM structure of omicron spike in complex with de novo designed binder, full map
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7zrv
Q-score: 0.4
Gainza P, Wehrle S, Van Hall-Beauvais A, Marchand A, Scheck A, Harteveld Z, Buckley S, Ni D, Tan S, Sverrisson F, Goverde C, Turelli P, Raclot C, Teslenko A, Pacesa M, Rosset S, Georgeon S, Marsden J, Petruzzella A, Liu K, Xu Z, Chai Y, Han P, Gao GF, Oricchio E, Fierz B, Trono D, Stahlberg H, Bronstein M, Correia BE
Nature (2023) 617 pp. 176-184 [ Pubmed: 37100904 DOI: doi:10.1038/s41586-023-05993-x ]
- Spike glycoprotein,envelope glycoprotein (142 kDa, Protein from Tequatrovirus T4)
- De novo designed binder (8 kDa, Protein from Drosophila melanogaster)
- Omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Omicron spike in complex with de novo designed binder, full map (Complex)
- De novo designed binder (Complex from Drosophila melanogaster)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
cryo-EM structure of omicron spike in complex with de novo designed binder, local
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 7zsd
Q-score: 0.431
Gainza P, Wehrle S, Van Hall-Beauvais A, Marchand A, Scheck A, Harteveld Z, Buckley S, Ni D, Tan S, Sverrisson F, Goverde C, Turelli P, Raclot C, Teslenko A, Pacesa M, Rosset S, Georgeon S, Marsden J, Petruzzella A, Liu K, Xu Z, Chai Y, Han P, Gao GF, Oricchio E, Fierz B, Trono D, Stahlberg H, Bronstein M, Correia BE
Nature (2023) 617 pp. 176-184 [ Pubmed: 37100904 DOI: doi:10.1038/s41586-023-05993-x ]
- Omicron spike in complex with de novo designed binder (450 kDa, Complex)
- De novo designed binder (8 kDa, Protein from Drosophila melanogaster)
- Spike glycoprotein (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- De novo designed binder (Complex from Drosophila melanogaster)
Resolution: 2.63 Å
EM Method: Single-particle
Fitted PDBs: 7zss
Q-score: 0.453
Gainza P, Wehrle S, Van Hall-Beauvais A, Marchand A, Scheck A, Harteveld Z, Buckley S, Ni D, Tan S, Sverrisson F, Goverde C, Turelli P, Raclot C, Teslenko A, Pacesa M, Rosset S, Georgeon S, Marsden J, Petruzzella A, Liu K, Xu Z, Chai Y, Han P, Gao GF, Oricchio E, Fierz B, Trono D, Stahlberg H, Bronstein M, Correia BE
Nature (2023) 617 pp. 176-184 [ Pubmed: 37100904 DOI: doi:10.1038/s41586-023-05993-x ]
- Spike glycoprotein (126 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- D614g spike in complex with de novo designed binder (450 kDa, Complex)
- De novo designed binder (8 kDa, Protein from Drosophila melanogaster)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- De novo designed binder (Complex from Drosophila melanogaster)
- D614g spike (Complex from Severe acute respiratory syndrome coronavirus 2)