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primary_citation_author:"Greenberg R" AND author_orcid:"0000-0001-6824-7382"
Cryo-EM structure of the human BRISC dimer complex bound to compound FX-171-C
Release date: Feb. 12, 2025
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8pvy
Q-score: 0.332
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8pvy
Q-score: 0.332
Chandler F, Reddy P, Bhutda S, Ross R, Walden M, Walker K, Cassel J, Prakesch M, Datti A, Campbell L, Foglizzo M, Bell L, Ault J, Al-awar R, Calabrese A, Sicheri F, Del Galdo F, Salvino J, Greenberg R, Zeqiraj E
To Be Published
Sample:
- Lys-63-specific deubiquitinase brcc36 (35 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- N-[(1r,5s)-3-azabicyclo[3.1.0]hexan-6-yl]-1-[2,6-bis(chloranyl)phenyl]carbonyl-4-[[2,6-bis(chloranyl)phenyl]carbonylamino]pyrazole-3-carboxamide (553 Da, Ligand)
- Brisc complex subunit abraxas 2 (31 kDa, Protein from Homo sapiens)
- Brisc and brca1-a complex member 2 (43 kDa, Protein from Homo sapiens)
- Brisc dimer in complex with inhibitor fx-171-c (654 kDa, Complex from Homo sapiens)
- Brisc and brca1-a complex member 1 (29 kDa, Protein from Homo sapiens)