Structure of human SARS-CoV-2 neutralizing antibody C1C-A3 Fab
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7sn2
Q-score: 0.399
Nabel KG, Clark SA, Shankar S, Pan J, Clark LE, Yang P, Coscia A, McKay LGA, Varnum HH, Brusic V, Tolan NV, Zhou G, Desjardins M, Turbett SE, Kanjilal S, Sherman AC, Dighe A, LaRocque RC, Ryan ET, Tylek C, Cohen-Solal JF, Darcy AT, Tavella D, Clabbers A, Fan Y, Griffiths A, Correia IR, Seagal J, Baden LR, Charles RC, Abraham J
Science (2022) 375 pp. eabl6251-eabl6251 [ DOI: doi:10.1126/science.abl6251 Pubmed: 34855508 ]
- Neutralizing antibody c1c-a3 fab light chain (25 kDa, Protein from Homo sapiens)
- C1c-a3 fab (Complex from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike protein sars-cov-2 hexapro (Complex from Severe acute respiratory syndrome coronavirus 2)
- Neutralizing antibody c1c-a3 fab heavy chain (27 kDa, Protein from Homo sapiens)
- Sars-cov-2_hexapro in complex with neutralizing antibody c1c-a3 fab from human patient (50 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7sn3
Q-score: 0.451
Nabel KG, Clark SA, Shankar S, Pan J, Clark LE, Yang P, Coscia A, McKay LGA, Varnum HH, Brusic V, Tolan NV, Zhou G, Desjardins M, Turbett SE, Kanjilal S, Sherman AC, Dighe A, LaRocque RC, Ryan ET, Tylek C, Cohen-Solal JF, Darcy AT, Tavella D, Clabbers A, Fan Y, Griffiths A, Correia IR, Seagal J, Baden LR, Charles RC, Abraham J
Science (2022) 375 pp. eabl6251-eabl6251 [ DOI: doi:10.1126/science.abl6251 Pubmed: 34855508 ]
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike protein trimer in complex with human patient antibody c1c-a3 fab (50 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Neutralizing antibody c1c-a3 heavy chain variable region (27 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Neutralizing antibody c1c-a3 light chain variable region (25 kDa, Protein from Homo sapiens)
- C1c-a3 fab (variable region) (Complex)
SARS-CoV-2 Spike Glycoprotein with one ACE2 Bound
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7kj2
Q-score: 0.355
Xiao T, Lu J, Zhang J, Johnson RI, McKay LGA, Storm N, Lavine CL, Peng H, Cai Y, Rits-Volloch S, Lu S, Quinlan BD, Farzan M, Seaman MS, Griffiths A, Chen B
Nat Struct Mol Biol (2021) 28 pp. 202-209 [ DOI: doi:10.1038/s41594-020-00549-3 Pubmed: 33432247 ]
- Spike glycoprotein (136 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Angiotensin-converting enzyme 2 (71 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike glycoprotein with one ace2 bound (475 MDa, Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 Spike Glycoprotein with two ACE2 Bound
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7kj3
Q-score: 0.308
Xiao T, Lu J, Zhang J, Johnson RI, McKay LGA, Storm N, Lavine CL, Peng H, Cai Y, Rits-Volloch S, Lu S, Quinlan BD, Farzan M, Seaman MS, Griffiths A, Chen B
Nat Struct Mol Biol (2021) 28 pp. 202-209 [ DOI: doi:10.1038/s41594-020-00549-3 Pubmed: 33432247 ]
- Sars-cov-2 spike glycoprotein with two ace2 bound (540 MDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (136 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Angiotensin-converting enzyme 2 (71 kDa, Protein from Homo sapiens)
SARS-CoV-2 Spike Glycoprotein with three ACE2 Bound
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7kj4
Q-score: 0.307
Xiao T, Lu J, Zhang J, Johnson RI, McKay LGA, Storm N, Lavine CL, Peng H, Cai Y, Rits-Volloch S, Lu S, Quinlan BD, Farzan M, Seaman MS, Griffiths A, Chen B
Nat Struct Mol Biol (2021) 28 pp. 202-209 [ DOI: doi:10.1038/s41594-020-00549-3 Pubmed: 33432247 ]
- Spike glycoprotein (136 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike glycoprotein with three ace2 bound (610 MDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Angiotensin-converting enzyme 2 (71 kDa, Protein from Homo sapiens)
SARS-CoV-2 Spike Glycoprotein, prefusion with one RBD up conformation
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7kj5
Q-score: 0.371
Xiao T, Lu J, Zhang J, Johnson RI, McKay LGA, Storm N, Lavine CL, Peng H, Cai Y, Rits-Volloch S, Lu S, Quinlan BD, Farzan M, Seaman MS, Griffiths A, Chen B
Nat Struct Mol Biol (2021) 28 pp. 202-209 [ DOI: doi:10.1038/s41594-020-00549-3 Pubmed: 33432247 ]