IMM20190 Fab complex with SARS-CoV-2 Spike Trimer
Nikitin PA, DiMuzio JM, Dowling JP, Patel NB, Bingaman-Steele JL, Heimbach BC, Henriquez N, Nicolescu C, Polley A, Sikorski EL, Howanski RJ, Nath M, Shukla H, Scheaffer SM, Finn JP, Liang LF, Smith T, Storm N, McKay LGA, Johnson RI, Malsick LE, Honko AN, Griffiths A, Diamond MS, Sarma P, Geising DH, Morin MJ, Robinson MK
Sci Immunol (2022) 7 pp. eabl9943-eabl9943 [ DOI: doi:10.1126/sciimmunol.abl9943 Pubmed: 35771946 ]
IMM20253 Fab complex with Trimer Spike protein of SARS-CoV-2 virus
Nikitin PA, DiMuzio JM, Dowling JP, Patel NB, Bingaman-Steele JL, Heimbach BC, Henriquez N, Nicolescu C, Polley A, Sikorski EL, Howanski RJ, Nath M, Shukla H, Scheaffer SM, Finn JP, Liang LF, Smith T, Storm N, McKay LGA, Johnson RI, Malsick LE, Honko AN, Griffiths A, Diamond MS, Sarma P, Geising DH, Morin MJ, Robinson MK
Sci Immunol (2022) 7 pp. eabl9943-eabl9943 [ DOI: doi:10.1126/sciimmunol.abl9943 Pubmed: 35771946 ]
IMM20253 Fab complex with Spike monomer
Nikitin PA, DiMuzio JM, Dowling JP, Patel NB, Bingaman-Steele JL, Heimbach BC, Henriquez N, Nicolescu C, Polley A, Sikorski EL, Howanski RJ, Nath M, Shukla H, Scheaffer SM, Finn JP, Liang LF, Smith T, Storm N, McKay LGA, Johnson RI, Malsick LE, Honko AN, Griffiths A, Diamond MS, Sarma P, Geising DH, Morin MJ, Robinson MK
Sci Immunol (2022) 7 pp. eabl9943-eabl9943 [ DOI: doi:10.1126/sciimmunol.abl9943 Pubmed: 35771946 ]
IMM20184 Fab complex with SARS-CoV-2 Spike Trimer
Nikitin PA, DiMuzio JM, Dowling JP, Patel NB, Bingaman-Steele JL, Heimbach BC, Henriquez N, Nicolescu C, Polley A, Sikorski EL, Howanski RJ, Nath M, Shukla H, Scheaffer SM, Finn JP, Liang LF, Smith T, Storm N, McKay LGA, Johnson RI, Malsick LE, Honko AN, Griffiths A, Diamond MS, Sarma P, Geising DH, Morin MJ, Robinson MK
Sci Immunol (2022) 7 pp. eabl9943-eabl9943 [ DOI: doi:10.1126/sciimmunol.abl9943 Pubmed: 35771946 ]
IMM20184 and IMM20253 Fabs in ternary complex with SARS-CoV-2 receptor binding domain
Nikitin PA, DiMuzio JM, Dowling JP, Patel NB, Bingaman-Steele JL, Heimbach BC, Henriquez N, Nicolescu C, Polley A, Sikorski EL, Howanski RJ, Nath M, Shukla H, Scheaffer SM, Finn JP, Liang LF, Smith T, Storm N, McKay LGA, Johnson RI, Malsick LE, Honko AN, Griffiths A, Diamond MS, Sarma P, Geising DH, Morin MJ, Robinson MK
Sci Immunol (2022) 7 pp. eabl9943-eabl9943 [ DOI: doi:10.1126/sciimmunol.abl9943 Pubmed: 35771946 ]
- Imm20184 fab (Complex from Homo sapiens)
- Imm20253 fab (Complex from Homo sapiens)
- Imm20184 and imm20253 fabs in ternary complex with rbd of sars-cov-2 (Complex from Severe acute respiratory syndrome coronavirus)
- Sars-cov-2 rbd (Complex from Severe acute respiratory syndrome coronavirus)
SARS-CoV-2 Spike Glycoprotein with one ACE2 Bound
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7kj2
Q-score: 0.355
Xiao T, Lu J, Zhang J, Johnson RI, McKay LGA, Storm N, Lavine CL, Peng H, Cai Y, Rits-Volloch S, Lu S, Quinlan BD, Farzan M, Seaman MS, Griffiths A, Chen B
Nat Struct Mol Biol (2021) 28 pp. 202-209 [ DOI: doi:10.1038/s41594-020-00549-3 Pubmed: 33432247 ]
- Spike glycoprotein (136 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Angiotensin-converting enzyme 2 (71 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike glycoprotein with one ace2 bound (475 MDa, Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 Spike Glycoprotein with two ACE2 Bound
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7kj3
Q-score: 0.308
Xiao T, Lu J, Zhang J, Johnson RI, McKay LGA, Storm N, Lavine CL, Peng H, Cai Y, Rits-Volloch S, Lu S, Quinlan BD, Farzan M, Seaman MS, Griffiths A, Chen B
Nat Struct Mol Biol (2021) 28 pp. 202-209 [ DOI: doi:10.1038/s41594-020-00549-3 Pubmed: 33432247 ]
- Sars-cov-2 spike glycoprotein with two ace2 bound (540 MDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (136 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Angiotensin-converting enzyme 2 (71 kDa, Protein from Homo sapiens)
SARS-CoV-2 Spike Glycoprotein with three ACE2 Bound
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7kj4
Q-score: 0.307
Xiao T, Lu J, Zhang J, Johnson RI, McKay LGA, Storm N, Lavine CL, Peng H, Cai Y, Rits-Volloch S, Lu S, Quinlan BD, Farzan M, Seaman MS, Griffiths A, Chen B
Nat Struct Mol Biol (2021) 28 pp. 202-209 [ DOI: doi:10.1038/s41594-020-00549-3 Pubmed: 33432247 ]
- Spike glycoprotein (136 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike glycoprotein with three ace2 bound (610 MDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Angiotensin-converting enzyme 2 (71 kDa, Protein from Homo sapiens)
SARS-CoV-2 Spike Glycoprotein, prefusion with one RBD up conformation
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7kj5
Q-score: 0.371
Xiao T, Lu J, Zhang J, Johnson RI, McKay LGA, Storm N, Lavine CL, Peng H, Cai Y, Rits-Volloch S, Lu S, Quinlan BD, Farzan M, Seaman MS, Griffiths A, Chen B
Nat Struct Mol Biol (2021) 28 pp. 202-209 [ DOI: doi:10.1038/s41594-020-00549-3 Pubmed: 33432247 ]