Integrin alpha-v beta-8 in complex with the Fab of 130H2
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 9ind
Q-score: 0.533
Guo C, Sun H, Du Y, Dai X, Pang Y, Han Z, Xiong X, Li S, Zhang J, Zheng Q, Gui X
J Exp Clin Cancer Res (2025) 44 pp. 1-1 [ DOI: doi:10.1186/s13046-024-03250-1 Pubmed: 39743547 ]
- Integrin alpha-v heavy chain (47 kDa, Protein from Homo sapiens)
- Integrin alpha-v beta-8 complexed with antibody fab fragment of 130h2 (Complex)
- Integrin beta-8 (39 kDa, Protein from Homo sapiens)
- 130h2-fab (Complex from Mus musculus)
- The light chain of 130h2-fab (11 kDa, Protein from Mus musculus)
- The heavy chain of 130h2-fab (13 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Integrin alpha-v beta-8 (Complex from Homo)
Qian Y, Ma Z, Xu Z, Duan Y, Xiong Y, Xia R, Zhu X, Zhang Z, Tian X, Yin H, Liu J, Song J, Lu Y, Zhang A, Guo C, Jin L, Kim WJ, Ke J, Xu F, Huang Z, He Y
Nat Commun (2024) 15 pp. 7644-7644 [ DOI: doi:10.1038/s41467-024-52174-z Pubmed: 39223191 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Gpcr complex (450 kDa, Complex from Homo sapiens)
- Segment polarity protein dishevelled homolog dvl-2 (79 kDa, Protein from Homo sapiens)
- Frizzled-4 (60 kDa, Protein from Homo sapiens)
Fzd4/DEP complex (local refined)
Qian Y, Ma Z, Xu Z, Duan Y, Xiong Y, Xia R, Zhu X, Zhang Z, Tian X, Yin H, Liu J, Song J, Lu Y, Zhang A, Guo C, Jin L, Kim WJ, Ke J, Xu F, Huang Z, He Y
Nat Commun (2024) 15 pp. 7644-7644 [ DOI: doi:10.1038/s41467-024-52174-z Pubmed: 39223191 ]
- Gpcr complex (450 kDa, Complex from Homo sapiens)
- Segment polarity protein dishevelled homolog dvl-2 (79 kDa, Protein from Homo sapiens)
- Frizzled-4 (60 kDa, Protein from Homo sapiens)
LPS-bound P2Y10 in complex with G13
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8kgg
Q-score: 0.518
Yin H, Kamakura N, Qian Y, Tatsumi M, Ikuta T, Liang J, Xu Z, Xia R, Zhang A, Guo C, Inoue A, He Y
Cell Chem Biol (2024) 31 pp. 1899-1908.e5 [ Pubmed: 39265572 DOI: doi:10.1016/j.chembiol.2024.08.005 ]
- Putative p2y purinoceptor 10 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-2,guanine nucleotide-binding protein subunit alpha-13 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- (2~{s})-2-$l^{4}-azanyl-3-[[(2~{r})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid (497 Da, Ligand)
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Structure of human TRPV4 with antagonist A1
Resolution: 3.74 Å
EM Method: Single-particle
Fitted PDBs: 8ju5
Q-score: 0.374
Fan J, Guo C, Liao D, Ke H, Lei J, Xie W, Tang Y, Tominaga M, Huang Z, Lei X
Adv Sci (2024) 11 pp. e2401583-e2401583 [ DOI: doi:10.1002/advs.202401583 Pubmed: 38659239 ]
- 4-[(3~{s},4~{s})-4-(aminomethyl)-1-(5-chloranylpyridin-2-yl)sulfonyl-4-oxidanyl-pyrrolidin-3-yl]oxy-2-fluoranyl-benzenecarbonitrile (426 Da, Ligand)
- Trpv4 (400 kDa, Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily v member 4,3c-gfp (128 kDa, Protein from synthetic construct)
Structure of human TRPV4 with antagonist GSK279
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8ju6
Q-score: 0.415
Fan J, Guo C, Liao D, Ke H, Lei J, Xie W, Tang Y, Tominaga M, Huang Z, Lei X
Adv Sci (2024) 11 pp. e2401583-e2401583 [ DOI: doi:10.1002/advs.202401583 Pubmed: 38659239 ]
- Trpv4 (400 kDa, Complex from Homo sapiens)
- 1-({(5s,7s)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1h-benzimidazole-6-carbonitrile (460 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 4,3c-gfp (128 kDa, Protein from synthetic construct)
Structure of human TRPV4 with antagonist A2
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 8jvi
Q-score: 0.418
Fan J, Guo C, Liao D, Ke H, Lei J, Xie W, Tang Y, Tominaga M, Huang Z, Lei X
Adv Sci (2024) 11 pp. e2401583-e2401583 [ DOI: doi:10.1002/advs.202401583 Pubmed: 38659239 ]
- [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{s},5~{r})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone (572 Da, Ligand)
- Trpv4 (400 kDa, Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily v member 4,3c-gfp (128 kDa, Protein from synthetic construct)
Structure of human TRPV4 with antagonist A2 and RhoA
Resolution: 3.44 Å
EM Method: Single-particle
Fitted PDBs: 8jvj
Q-score: 0.378
Fan J, Guo C, Liao D, Ke H, Lei J, Xie W, Tang Y, Tominaga M, Huang Z, Lei X
Adv Sci (2024) 11 pp. e2401583-e2401583 [ DOI: doi:10.1002/advs.202401583 Pubmed: 38659239 ]
- [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{s},5~{r})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone (572 Da, Ligand)
- Complex of trpv4 and rhoa (400 kDa, Complex from Homo sapiens)
- Transforming protein rhoa (21 kDa, Protein from Homo sapiens)
- Transient receptor potential cation channel subfamily v member 4,3c-gfp (128 kDa, Protein from synthetic construct)
Cryo-EM structure of the ISFba1 TnpB-reRNA-dsDNA complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8iaz
Q-score: 0.548
Ren K, Zhou F, Zhang F, Yin M, Zhu Y, Wang S, Chen Y, Huang T, Wu Z, He J, Zhang A, Guo C, Huang Z
Cell Res (2024) 34 pp. 370-385 [ Pubmed: 38575718 DOI: doi:10.1038/s41422-024-00952-1 ]
- Dna (5'-d(p*cp*cp*ap*tp*tp*ap*gp*gp*ap*gp*cp*tp*gp*ap*tp*g)-3') (4 kDa, DNA from Firmicutes bacterium AM43-11BH)
- Rna (207-mer) (66 kDa, RNA from Firmicutes bacterium AM43-11BH)
- Dna (5'-d(p*ap*cp*ap*tp*gp*gp*ap*cp*cp*ap*tp*cp*ap*gp*cp*tp*cp*cp*tp*ap*ap*tp*gp*g)-3') (7 kDa, DNA from Firmicutes bacterium AM43-11BH)
- Transposase (44 kDa, Protein from Firmicutes bacterium AM43-11BH)
- The complex of protein with grna and target dna (Complex from Firmicutes bacterium AM43-11BH)
- Zinc ion (65 Da, Ligand)
Histamine-bound H4R/Gi complex
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8jxt
Q-score: 0.472
Xia R, Shi S, Xu Z, Vischer HF, Windhorst AD, Qian Y, Duan Y, Liang J, Chen K, Zhang A, Guo C, Leurs R, He Y
Nat Commun (2024) 15 pp. 2493-2493 [ DOI: doi:10.1038/s41467-024-46840-5 Pubmed: 38509098 ]
- Histamine (111 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Histamine h4 receptor (44 kDa, Protein from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
- Gpcr/g-protein complex (130 MDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)