Cryo-EM structure of the ISFba1 TnpB-reRNA-dsDNA complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8iaz
Q-score: 0.548
Ren K, Zhou F, Zhang F, Yin M, Zhu Y, Wang S, Chen Y, Huang T, Wu Z, He J, Zhang A, Guo C, Huang Z
Cell Res (2024) 34 pp. 370-385 [ DOI: doi:10.1038/s41422-024-00952-1 Pubmed: 38575718 ]
- Rna (207-mer) (66 kDa, RNA from Firmicutes bacterium AM43-11BH)
- Transposase (44 kDa, Protein from Firmicutes bacterium AM43-11BH)
- Dna (5'-d(p*cp*cp*ap*tp*tp*ap*gp*gp*ap*gp*cp*tp*gp*ap*tp*g)-3') (4 kDa, DNA from Firmicutes bacterium AM43-11BH)
- The complex of protein with grna and target dna (Complex from Firmicutes bacterium AM43-11BH)
- Dna (5'-d(p*ap*cp*ap*tp*gp*gp*ap*cp*cp*ap*tp*cp*ap*gp*cp*tp*cp*cp*tp*ap*ap*tp*gp*g)-3') (7 kDa, DNA from Firmicutes bacterium AM43-11BH)
- Zinc ion (65 Da, Ligand)
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8ww2
Q-score: 0.577
Xiong Y, Xu Z, Li X, Wang Y, Zhao J, Wang N, Duan Y, Xia R, Han Z, Qian Y, Liang J, Zhang A, Guo C, Inoue A, Xia Y, Chen Z, He Y
Cell Res (2024) 34 pp. 232-244 [ DOI: doi:10.1038/s41422-024-00932-5 Pubmed: 38287117 ]
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Nb35 (15 kDa, Protein from Lama glama)
- Palmitic acid (256 Da, Ligand)
- G-protein coupled receptor 3 (35 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Oleic acid (282 Da, Ligand)
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 7yub
Q-score: 0.513
Duan Y, Leong NCP, Zhao J, Zhang Y, Nguyen DT, Ha HTT, Wang N, Xia R, Xu Z, Ma Z, Qian Y, Yin H, Zhu X, Zhang A, Guo C, Xia Y, Nguyen LN, He Y
Cell Res (2024) 34 pp. 177-180 [ DOI: doi:10.1038/s41422-023-00913-0 Pubmed: 38123825 ]
- Nbfab-l-chain (23 kDa, Protein from synthetic construct)
- Nbfab-h-chain (26 kDa, Protein from synthetic construct)
- Sphingosine-1-phosphate transporter spns2 (58 kDa, Protein from Homo sapiens)
- Tc-nb8 (14 kDa, Protein from Lama glama)
- (2s,3r,4e)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (379 Da, Ligand)
- Spns2 nanobody complex (Complex from Lama glama)
DHA-bound FFAR4 in complex with Gs
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8h4i
Q-score: 0.574
Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y
Cell Res (2023) 33 pp. 644-647 [ DOI: doi:10.1038/s41422-023-00835-x Pubmed: 37286793 ]
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nb35 (17 kDa, Protein from Lama glama)
- Engineered mini galpha-s subunit (41 kDa, Protein from Homo sapiens)
- Docosa-4,7,10,13,16,19-hexaenoic acid (328 Da, Ligand)
- Free fatty acid receptor 4 (40 kDa, Protein from Homo sapiens)
GW9508-bound FFAR4 in complex with Gq
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8h4k
Q-score: 0.545
Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y
Cell Res (2023) 33 pp. 644-647 [ DOI: doi:10.1038/s41422-023-00835-x Pubmed: 37286793 ]
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Engineered mini galpha-q subunit (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nb35 (17 kDa, Protein from Lama glama)
- 3-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propanoic acid (347 Da, Ligand)
- Free fatty acid receptor 4 (40 kDa, Protein from Homo sapiens)
DHA-bound FFAR4 in complex with Gq
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8h4l
Q-score: 0.546
Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y
Cell Res (2023) 33 pp. 644-647 [ DOI: doi:10.1038/s41422-023-00835-x Pubmed: 37286793 ]
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Engineered mini galpha-q subunit (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nb35 (17 kDa, Protein from Lama glama)
- Docosa-4,7,10,13,16,19-hexaenoic acid (328 Da, Ligand)
- Free fatty acid receptor 4 (40 kDa, Protein from Homo sapiens)
TUG891-bound FFAR4 in complex with Gq
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8iys
Q-score: 0.502
Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y
Cell Res (2023) 33 pp. 644-647 [ DOI: doi:10.1038/s41422-023-00835-x Pubmed: 37286793 ]
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid (364 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Free fatty acid receptor 4 (40 kDa, Protein from Homo sapiens)
Human bile salt exporter ABCB11 in complex with taurocholate
Resolution: 3.66 Å
EM Method: Single-particle
Fitted PDBs: 7e1a
Q-score: 0.412
Wang L, Hou WT, Wang J, Xu D, Guo C, Sun L, Ruan K, Zhou CZ, Chen Y
Cell Res (2022) 32 pp. 501-504 [ Pubmed: 35043010 DOI: doi:10.1038/s41422-021-00611-9 ]
- Taurocholic acid (515 Da, Ligand)
- Bile salt export pump (146 kDa, Protein from Homo sapiens)
- Human abcb11 in complex with taurocholate (150 kDa, Complex from Homo sapiens)
Human bile salt exporter ABCB11 in complex with taurocholate
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7dv5
Q-score: 0.433
Wang L, Hou WT, Wang J, Xu D, Guo C, Sun L, Ruan K, Zhou CZ, Chen Y
Cell Res (2022) 32 pp. 501-504 [ Pubmed: 35043010 DOI: doi:10.1038/s41422-021-00611-9 ]
- Human abcb11 in complex with taurocholate (146 MDa, Complex from Homo sapiens)
- Bile salt export pump (140 kDa, Protein from Homo sapiens)
- Taurocholic acid (515 Da, Ligand)