Qian Y, Ma Z, Xu Z, Duan Y, Xiong Y, Xia R, Zhu X, Zhang Z, Tian X, Yin H, Liu J, Song J, Lu Y, Zhang A, Guo C, Jin L, Kim WJ, Ke J, Xu F, Huang Z, He Y
Nat Commun (2024) 15 pp. 7644-7644 [ DOI: doi:10.1038/s41467-024-52174-z Pubmed: 39223191 ]
- Frizzled-4 (60 kDa, Protein from Homo sapiens)
- Segment polarity protein dishevelled homolog dvl-2 (79 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Gpcr complex (450 kDa, Complex from Homo sapiens)
Histamine-bound H4R/Gi complex
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8jxt
Q-score: 0.472
Xia R, Shi S, Xu Z, Vischer HF, Windhorst AD, Qian Y, Duan Y, Liang J, Chen K, Zhang A, Guo C, Leurs R, He Y
Nat Commun (2024) 15 pp. 2493-2493 [ Pubmed: 38509098 DOI: doi:10.1038/s41467-024-46840-5 ]
- Histamine (111 Da, Ligand)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Gpcr/g-protein complex (130 MDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Histamine h4 receptor (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8ww2
Q-score: 0.577
Xiong Y, Xu Z, Li X, Wang Y, Zhao J, Wang N, Duan Y, Xia R, Han Z, Qian Y, Liang J, Zhang A, Guo C, Inoue A, Xia Y, Chen Z, He Y
Cell Res (2024) 34 pp. 232-244 [ DOI: doi:10.1038/s41422-024-00932-5 Pubmed: 38287117 ]
- Palmitic acid (256 Da, Ligand)
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Oleic acid (282 Da, Ligand)
- G-protein coupled receptor 3 (35 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 7yub
Q-score: 0.513
Duan Y, Leong NCP, Zhao J, Zhang Y, Nguyen DT, Ha HTT, Wang N, Xia R, Xu Z, Ma Z, Qian Y, Yin H, Zhu X, Zhang A, Guo C, Xia Y, Nguyen LN, He Y
Cell Res (2024) 34 pp. 177-180 [ DOI: doi:10.1038/s41422-023-00913-0 Pubmed: 38123825 ]
- Spns2 nanobody complex (Complex from Lama glama)
- Nbfab-h-chain (26 kDa, Protein from synthetic construct)
- (2s,3r,4e)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (379 Da, Ligand)
- Sphingosine-1-phosphate transporter spns2 (58 kDa, Protein from Homo sapiens)
- Tc-nb8 (14 kDa, Protein from Lama glama)
- Nbfab-l-chain (23 kDa, Protein from synthetic construct)
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 8jwf
Q-score: 0.354
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8jwg
Q-score: 0.335
Cryo-EM structure of the outward-facing Plasmodium falciparum multidrug resistance protein 1
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8jwi
Q-score: 0.504
Si K, He X, Chen L, Zhang A, Guo C, Li M
PNAS (2023) 120 pp. e2219905120-e2219905120 [ DOI: doi:10.1073/pnas.2219905120 Pubmed: 37527341 ]
- Plasmodium falciparum multidrug resistance protein 1 in the outward-facing conformation (Complex from Plasmodium falciparum (isolate 3D7))
- Magnesium ion (24 Da, Ligand)
- Multidrug resistance protein 1 (158 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- Adenosine-5'-triphosphate (507 Da, Ligand)
DHA-bound FFAR4 in complex with Gs
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8h4i
Q-score: 0.574
Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y
Cell Res (2023) 33 pp. 644-647 [ DOI: doi:10.1038/s41422-023-00835-x Pubmed: 37286793 ]
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Docosa-4,7,10,13,16,19-hexaenoic acid (328 Da, Ligand)
- Engineered mini galpha-s subunit (41 kDa, Protein from Homo sapiens)
- Nb35 (17 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Free fatty acid receptor 4 (40 kDa, Protein from Homo sapiens)
GW9508-bound FFAR4 in complex with Gq
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8h4k
Q-score: 0.545
Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y
Cell Res (2023) 33 pp. 644-647 [ DOI: doi:10.1038/s41422-023-00835-x Pubmed: 37286793 ]
- Engineered mini galpha-q subunit (41 kDa, Protein from Homo sapiens)
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Nb35 (17 kDa, Protein from Lama glama)
- 3-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propanoic acid (347 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Free fatty acid receptor 4 (40 kDa, Protein from Homo sapiens)
DHA-bound FFAR4 in complex with Gq
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8h4l
Q-score: 0.546
Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y
Cell Res (2023) 33 pp. 644-647 [ DOI: doi:10.1038/s41422-023-00835-x Pubmed: 37286793 ]
- Engineered mini galpha-q subunit (41 kDa, Protein from Homo sapiens)
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Docosa-4,7,10,13,16,19-hexaenoic acid (328 Da, Ligand)
- Nb35 (17 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Free fatty acid receptor 4 (40 kDa, Protein from Homo sapiens)