Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8xx4
Q-score: 0.605
Zhu G, Xi F, Zeng W, Zhao Y, Cao W, Liu C, Yang F, Ru Y, Xiao S, Zhang S, Liu H, Tian H, Yang F, Lu B, Sun S, Song H, Sun B, Zhao X, Tang L, Li K, He J, Guo J, Zhu Y, Zhu Z, Sun F, Zheng H
Nat Commun (2025) 16 pp. 501-501 [ Pubmed: 39779680 DOI: doi:10.1038/s41467-024-55683-z ]
- Zinc ion (65 Da, Ligand)
- Asfv rnap elongation complex (Complex from African swine fever virus)
- Dna (5'-d(p*tp*tp*cp*gp*cp*cp*gp*tp*tp*gp*cp*gp*tp*ap*tp*tp*tp*gp*tp*gp*tp*ap*g)-3') (7 kDa, DNA from African swine fever virus)
- Dna-directed rna polymerase rpb5 homolog (23 kDa, Protein from African swine fever virus)
- D339l (9 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase subunit beta (138 kDa, Protein from African swine fever virus)
- Rna (5'-r(p*cp*up*ap*cp*ap*cp*ap*ap*a)-3') (2 kDa, RNA from African swine fever virus)
- Rna polymerase subunit 6 (12 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb10 homolog (9 kDa, Protein from African swine fever virus)
- Magnesium ion (24 Da, Ligand)
- Dna (5'-d(p*cp*gp*cp*ap*ap*cp*gp*gp*cp*gp*a)-3') (3 kDa, DNA from African swine fever virus)
- Dna-directed rna polymerase subunit (162 kDa, Protein from African swine fever virus)
- C122r (11 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb3-11 homolog (41 kDa, Protein from African swine fever virus)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8xxp
Q-score: 0.591
Zhu G, Xi F, Zeng W, Zhao Y, Cao W, Liu C, Yang F, Ru Y, Xiao S, Zhang S, Liu H, Tian H, Yang F, Lu B, Sun S, Song H, Sun B, Zhao X, Tang L, Li K, He J, Guo J, Zhu Y, Zhu Z, Sun F, Zheng H
Nat Commun (2025) 16 pp. 501-501 [ Pubmed: 39779680 DOI: doi:10.1038/s41467-024-55683-z ]
- Zinc ion (65 Da, Ligand)
- D339l (16 kDa, Protein from African swine fever virus)
- C147l (11 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb10 homolog (9 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb5 homolog (23 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase subunit beta (139 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb3-11 homolog (41 kDa, Protein from African swine fever virus)
- Magnesium ion (24 Da, Ligand)
- Asfv rnap core complex (Complex from African swine fever virus)
- Dna-directed rna polymerase subunit (162 kDa, Protein from African swine fever virus)
- C122r (11 kDa, Protein from African swine fever virus)
ASFV RNAP M1249L C-tail occupied complex3 (MCOC3)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xy6
Q-score: 0.519
Zhu G, Xi F, Zeng W, Zhao Y, Cao W, Liu C, Yang F, Ru Y, Xiao S, Zhang S, Liu H, Tian H, Yang F, Lu B, Sun S, Song H, Sun B, Zhao X, Tang L, Li K, He J, Guo J, Zhu Y, Zhu Z, Sun F, Zheng H
Nat Commun (2025) 16 pp. 501-501 [ Pubmed: 39779680 DOI: doi:10.1038/s41467-024-55683-z ]
- Zinc ion (65 Da, Ligand)
- M1249l (66 kDa, Protein from African swine fever virus)
- D339l (16 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb10 homolog (9 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb5 homolog (23 kDa, Protein from African swine fever virus)
- C147l (14 kDa, Protein from African swine fever virus)
- Asfv rnap m1249l c-tail occupied complex3 (mcoc3) (Complex from African swine fever virus)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerase subunit beta (139 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase subunit (162 kDa, Protein from African swine fever virus)
- C122r (11 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb3-11 homolog (41 kDa, Protein from African swine fever virus)
Cryo-EM of helical fibers formed by two peptides Pyn-K6 and Pyn-(EY)3
Resolution: 3.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 9d70
Q-score: 0.39
Qiao Y, Zia A, Wu G, Liu Z, Guo J, Chu M, He H, Wang F, Xu B
J Am Chem Soc (2025) 147 pp. 2978-2983 [ Pubmed: 39808585 DOI: doi:10.1021/jacs.4c12150 ]
- Pyn-k6 + pyn-ey3 fiber (Complex from synthetic construct)
- Pyr-k6 (1 kDa, Protein from synthetic construct)
- (pyren-1-yl)acetic acid (260 Da, Ligand)
- Pyr-ey3 (1 kDa, Protein from synthetic construct)
mGlu2-4 heterodimer bound with Gi
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8wgb
Q-score: 0.331
Huang W, Jin N, Guo J, Shen C, Xu C, Xi K, Bonhomme L, Quast RB, Shen DD, Qin J, Liu YR, Song Y, Gao Y, Margeat E, Rondard P, Pin JP, Zhang Y, Liu J
Nat Commun (2024) 15 pp. 10345-10345 [ Pubmed: 39609406 DOI: doi:10.1038/s41467-024-54744-7 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Mglu2-mglu4 heterodimer bound gi (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
- Metabotropic glutamate receptor 4 (98 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Glutamic acid (147 Da, Ligand)
- (1r,2s)-2-[[3,5-bis(chloranyl)phenyl]carbamoyl]cyclohexane-1-carboxylic acid (316 Da, Ligand)
- Metabotropic glutamate receptor 2 (93 kDa, Protein from Homo sapiens)
human KCNQ2-CaM-Ebio1 complex in the presence of PIP2
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ijk
Q-score: 0.383
Zhang S, Ma D, Wang K, Li Y, Yang Z, Li X, Li J, He J, Mei L, Ye Y, Chen Z, Shen J, Hou P, Guo J, Zhang Q, Yang H
Nat Chem Biol (2024) 20 pp. 847-856 [ Pubmed: 38167918 DOI: doi:10.1038/s41589-023-01515-y ]
- N-(1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide (291 Da, Ligand)
- Human kcnq2-cam-ebio1 complex in the presence of pip2 (Complex from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
human KCNQ2-CaM-Ebio1-S1 complex in the presence of PIP2
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8x43
Q-score: 0.328
Zhang S, Ma D, Wang K, Li Y, Yang Z, Li X, Li J, He J, Mei L, Ye Y, Chen Z, Shen J, Hou P, Guo J, Zhang Q, Yang H
Nat Chem Biol (2024) 20 pp. 847-856 [ Pubmed: 38167918 DOI: doi:10.1038/s41589-023-01515-y ]
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Human kcnq2-cam-ebio1-s1 complex in the presence of pip2 (Cellular component from Homo sapiens)
- N-(4-azanyl-1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide (306 Da, Ligand)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
Human KCNQ2-CaM in complex with CBD and PIP2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8j01
Q-score: 0.421
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J
Nat Commun (2023) 14 pp. 6632-6632 [ Pubmed: 37857637 DOI: doi:10.1038/s41467-023-42416-x ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Calmodulin-1 (19 kDa, Protein from Homo sapiens)
- Human kcnq2-cam in complex with cbd and pip2 (Complex from Homo sapiens)
- Cannabidiol (314 Da, Ligand)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state II
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8j02
Q-score: 0.348
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J
Nat Commun (2023) 14 pp. 6632-6632 [ Pubmed: 37857637 DOI: doi:10.1038/s41467-023-42416-x ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Calmodulin-1 (19 kDa, Protein from Homo sapiens)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- Cannabidiol (314 Da, Ligand)
- Human kcnq2(f104a)-cam-pip2-cbd complex in state ii (Complex from Homo sapiens)
human KCNQ2-CaM in complex with PIP2 and HN37
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8w4u
Q-score: 0.354
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J
Nat Commun (2023) 14 pp. 6632-6632 [ Pubmed: 37857637 DOI: doi:10.1038/s41467-023-42416-x ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Human kcnq2-cam in complex with pip2 and hn37 (Cellular component from Homo sapiens)
- Methyl n-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate (340 Da, Ligand)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)