Rat Kir4.1 in complex with PIP2
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8i5m
Q-score: 0.486
Zhou X, Zhao C, Xu H, Xu Y, Zhan L, Wang P, He J, Lu T, Gu Y, Yang Y, Xu C, Chen Y, Liu Y, Zeng Y, Tian F, Chen Q, Xie X, Liu J, Hu H, Li J, Zheng Y, Guo J, Gao Z
Nat Chem Biol (2024) 20 pp. 857-866 [ DOI: doi:10.1038/s41589-024-01555-y Pubmed: 38355723 ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 10 (38 kDa, Protein from Rattus norvegicus)
- Rat kir4.1 in complex with pip2 (Complex from Rattus norvegicus)
Rat Kir4.1 in complex with PIP2 and Lys05
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8i5n
Q-score: 0.414
Zhou X, Zhao C, Xu H, Xu Y, Zhan L, Wang P, He J, Lu T, Gu Y, Yang Y, Xu C, Chen Y, Liu Y, Zeng Y, Tian F, Chen Q, Xie X, Liu J, Hu H, Li J, Zheng Y, Guo J, Gao Z
Nat Chem Biol (2024) 20 pp. 857-866 [ DOI: doi:10.1038/s41589-024-01555-y Pubmed: 38355723 ]
- Rat kir4.1 in complex with pip2 and lys05 (Complex from Rattus norvegicus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 10 (38 kDa, Protein from Rattus norvegicus)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7wks
Q-score: 0.527
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 7wkw
Q-score: 0.448
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 7xxb
Q-score: 0.526
Su N, Zhu A, Tao X, Ding ZJ, Chang S, Ye F, Zhang Y, Zhao C, Chen Q, Wang J, Zhou CY, Guo Y, Jiao S, Zhang S, Wen H, Ma L, Ye S, Zheng SJ, Yang F, Wu S, Guo J
Nature (2022) 609 pp. 616-621 [ DOI: doi:10.1038/s41586-022-05142-w Pubmed: 35917926 ]
- Auxin efflux carrier component 3 (73 kDa, Protein from Arabidopsis thaliana)
- Iaa-bound state atpin3(atpin3-iaa) (Complex from Arabidopsis thaliana)
- 1h-indol-3-ylacetic acid (175 Da, Ligand)
Cryo-EM structure of human TPC2 channel in the ligand-bound open state
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6nq0
Q-score: 0.455
Cryo-EM structure of human TPC2 channel in the apo state
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6nq1
Q-score: 0.441
She J, Zeng W, Guo J, Chen Q, Bai X, Jiang Y
eLife (2019) 8 [ DOI: doi:10.7554/eLife.45222 Pubmed: 30860481 ]
- Two-pore channel 2 (Complex from Homo sapiens)
- Two pore calcium channel protein 2 (85 kDa, Protein from Homo sapiens)
Cryo-EM structure of human TPC2 channel in the ligand-bound closed state
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6nq2
Q-score: 0.491
She J, Zeng W, Guo J, Chen Q, Bai X, Jiang Y
eLife (2019) 8 [ DOI: doi:10.7554/eLife.45222 Pubmed: 30860481 ]
- Two pore calcium channel protein 2 (85 kDa, Protein from Homo sapiens)
- The complex of two-pore channel 2 with pi(3,5)p2 (Complex from Homo sapiens)
- (2r)-3-{[(s)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate (746 Da, Ligand)
Cryo-EM structure of mouse TPC1 channel in the apo state
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6c96
Q-score: 0.456
She J, Guo J, Chen Q, Zeng W, Jiang Y, Bai XC
Nature (2018) 556 pp. 130-134 [ Pubmed: 29562233 DOI: doi:10.1038/nature26139 ]
- Sodium ion (22 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Apo mouse tpc1 (Cellular component from Mus musculus)
- Two pore calcium channel protein 1 (95 kDa, Protein from Mus musculus)
Cryo-EM structure of mouse TPC1 channel in the PtdIns(3,5)P2-bound state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6c9a
Q-score: 0.49
She J, Guo J, Chen Q, Zeng W, Jiang Y, Bai XC
Nature (2018) 556 pp. 130-134 [ Pubmed: 29562233 DOI: doi:10.1038/nature26139 ]
- Ptdins(3,5)p2-bound mouse tpc1 (Cellular component from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (2r)-3-{[(s)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate (746 Da, Ligand)
- Two pore calcium channel protein 1 (95 kDa, Protein from Mus musculus)