Cryo-EM structure of human apo GPR156
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8yjp
Q-score: 0.396
Ma X, Chen LN, Liao M, Zhang L, Xi K, Guo J, Shen C, Shen DD, Cai P, Shen Q, Qi J, Zhang H, Zang SK, Dong YJ, Miao L, Qin J, Ji SY, Li Y, Liu J, Mao C, Zhang Y, Chai R
Nat Commun (2024) 15 pp. 10601-10601 [ Pubmed: 39638804 DOI: doi:10.1038/s41467-024-54681-5 ]
- Probable g-protein coupled receptor 156 (38 kDa, Protein from Homo sapiens)
- (21r,24r,27s)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9z)-octadec-9-enoate (777 Da, Ligand)
- Gpr156 (Cellular component from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of human GPR156-Gi3 complex
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8yk0
Q-score: 0.501
Ma X, Chen LN, Liao M, Zhang L, Xi K, Guo J, Shen C, Shen DD, Cai P, Shen Q, Qi J, Zhang H, Zang SK, Dong YJ, Miao L, Qin J, Ji SY, Li Y, Liu J, Mao C, Zhang Y, Chai R
Nat Commun (2024) 15 pp. 10601-10601 [ Pubmed: 39638804 DOI: doi:10.1038/s41467-024-54681-5 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Bos taurus)
- Probable g-protein coupled receptor 156 (32 kDa, Protein from Homo sapiens)
- (21r,24r,27s)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9z)-octadec-9-enoate (777 Da, Ligand)
- Gpr156-gi3 complex (Cellular component from Homo sapiens)
- Probable g-protein coupled receptor 156 (35 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
heterodimer of mGlu2 and mGlu4 bound with mGlu2 agonist LY379268
Resolution: 5.95 Å
EM Method: Single-particle
Fitted PDBs: 8wgc
Q-score: 0.215
Huang W, Jin N, Guo J, Shen C, Xu C, Xi K, Bonhomme L, Quast RB, Shen DD, Qin J, Liu YR, Song Y, Gao Y, Margeat E, Rondard P, Pin JP, Zhang Y, Liu J
Nat Commun (2024) 15 pp. 10345-10345 [ Pubmed: 39609406 DOI: doi:10.1038/s41467-024-54744-7 ]
- Heterodimer of mglu2 and mglu4 bound with mglu2 agonist ly379268 (Complex from Homo sapiens)
- (1r,4r,5s,6r)-4-azanyl-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid (187 Da, Ligand)
- Metabotropic glutamate receptor 4 (98 kDa, Protein from Homo sapiens)
- Metabotropic glutamate receptor 2 (93 kDa, Protein from Homo sapiens)
Cryo-EM structure of mGlu2-mGlu4 bound mGlu2 agonist LY379268
Cryo-EM structure of mGlu2-mGlu4 bound mGlu2 agonist LY379268
mGlu2-4 heterodimer bound with Gi
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8wgb
Q-score: 0.331
Huang W, Jin N, Guo J, Shen C, Xu C, Xi K, Bonhomme L, Quast RB, Shen DD, Qin J, Liu YR, Song Y, Gao Y, Margeat E, Rondard P, Pin JP, Zhang Y, Liu J
Nat Commun (2024) 15 pp. 10345-10345 [ Pubmed: 39609406 DOI: doi:10.1038/s41467-024-54744-7 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Mglu2-mglu4 heterodimer bound gi (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
- Metabotropic glutamate receptor 4 (98 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Glutamic acid (147 Da, Ligand)
- (1r,2s)-2-[[3,5-bis(chloranyl)phenyl]carbamoyl]cyclohexane-1-carboxylic acid (316 Da, Ligand)
- Metabotropic glutamate receptor 2 (93 kDa, Protein from Homo sapiens)
Cryo-EM focused refined map of mGlu2-mGlu4 heterodimer bound with Gi
Cryo-EM focused refined map of mGlu2-mGlu4 heterodimer bound with Gi