heterodimer of mGlu2 and mGlu4 bound with mGlu2 agonist LY379268
Resolution: 5.95 Å
EM Method: Single-particle
Fitted PDBs: 8wgc
Q-score: 0.215
Huang W, Jin N, Guo J, Shen C, Xu C, Xi K, Bonhomme L, Quast RB, Shen DD, Qin J, Liu YR, Song Y, Gao Y, Margeat E, Rondard P, Pin JP, Zhang Y, Liu J
Nat Commun (2024) 15 pp. 10345-10345 [ DOI: doi:10.1038/s41467-024-54744-7 Pubmed: 39609406 ]
- Metabotropic glutamate receptor 2 (93 kDa, Protein from Homo sapiens)
- (1r,4r,5s,6r)-4-azanyl-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid (187 Da, Ligand)
- Heterodimer of mglu2 and mglu4 bound with mglu2 agonist ly379268 (Complex from Homo sapiens)
- Metabotropic glutamate receptor 4 (98 kDa, Protein from Homo sapiens)
Cryo-EM structure of mGlu2-mGlu4 bound mGlu2 agonist LY379268
Cryo-EM structure of mGlu2-mGlu4 bound mGlu2 agonist LY379268
mGlu2-4 heterodimer bound with Gi
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8wgb
Q-score: 0.331
Huang W, Jin N, Guo J, Shen C, Xu C, Xi K, Bonhomme L, Quast RB, Shen DD, Qin J, Liu YR, Song Y, Gao Y, Margeat E, Rondard P, Pin JP, Zhang Y, Liu J
Nat Commun (2024) 15 pp. 10345-10345 [ DOI: doi:10.1038/s41467-024-54744-7 Pubmed: 39609406 ]
- (1r,2s)-2-[[3,5-bis(chloranyl)phenyl]carbamoyl]cyclohexane-1-carboxylic acid (316 Da, Ligand)
- Metabotropic glutamate receptor 2 (93 kDa, Protein from Homo sapiens)
- Mglu2-mglu4 heterodimer bound gi (Complex from Homo sapiens)
- Glutamic acid (147 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Metabotropic glutamate receptor 4 (98 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
Cryo-EM focused refined map of mGlu2-mGlu4 heterodimer bound with Gi
Cryo-EM focused refined map of mGlu2-mGlu4 heterodimer bound with Gi
Rat Kir4.1 in complex with PIP2
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8i5m
Q-score: 0.486
Zhou X, Zhao C, Xu H, Xu Y, Zhan L, Wang P, He J, Lu T, Gu Y, Yang Y, Xu C, Chen Y, Liu Y, Zeng Y, Tian F, Chen Q, Xie X, Liu J, Hu H, Li J, Zheng Y, Guo J, Gao Z
Nat Chem Biol (2024) 20 pp. 857-866 [ Pubmed: 38355723 DOI: doi:10.1038/s41589-024-01555-y ]
- Rat kir4.1 in complex with pip2 (Complex from Rattus norvegicus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 10 (38 kDa, Protein from Rattus norvegicus)
Rat Kir4.1 in complex with PIP2 and Lys05
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8i5n
Q-score: 0.414
Zhou X, Zhao C, Xu H, Xu Y, Zhan L, Wang P, He J, Lu T, Gu Y, Yang Y, Xu C, Chen Y, Liu Y, Zeng Y, Tian F, Chen Q, Xie X, Liu J, Hu H, Li J, Zheng Y, Guo J, Gao Z
Nat Chem Biol (2024) 20 pp. 857-866 [ Pubmed: 38355723 DOI: doi:10.1038/s41589-024-01555-y ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Rat kir4.1 in complex with pip2 and lys05 (Complex from Rattus norvegicus)
- Atp-sensitive inward rectifier potassium channel 10 (38 kDa, Protein from Rattus norvegicus)