Cryo-EM structure of human GPR156-Gi3 complex
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8yk0
Q-score: 0.501
Ma X, Chen LN, Liao M, Zhang L, Xi K, Guo J, Shen C, Shen DD, Cai P, Shen Q, Qi J, Zhang H, Zang SK, Dong YJ, Miao L, Qin J, Ji SY, Li Y, Liu J, Mao C, Zhang Y, Chai R
Nat Commun (2024) 15 pp. 10601-10601 [ DOI: doi:10.1038/s41467-024-54681-5 Pubmed: 39638804 ]
- Gpr156-gi3 complex (Cellular component from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Probable g-protein coupled receptor 156 (32 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Bos taurus)
- Cholesterol (386 Da, Ligand)
- (21r,24r,27s)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9z)-octadec-9-enoate (777 Da, Ligand)
- Probable g-protein coupled receptor 156 (35 kDa, Protein from Homo sapiens)
Cryo-EM structure of the tethered agonist-bound human PAR1-Gq complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xor
Q-score: 0.513
Guo J, Zhou YL, Yang Y, Guo S, You E, Xie X, Jiang Y, Mao C, Xu HE, Zhang Y
Cell Res (2024) 34 pp. 725-734 [ Pubmed: 38997424 DOI: doi:10.1038/s41422-024-00997-2 ]
- G(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (32 kDa, Protein from Mus musculus)
- Scfv16 (Complex from Homo sapiens)
- Gi1-gq chimeric (Complex from Mus musculus)
- Proteinase-activated receptor 1 lgbit (58 kDa, Protein from Homo sapiens)
- Cryo-em structure of ligand-bound form of the receptor in complex with the transducer (Complex from Rattus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus)
- G subunit q (gi1-gq chimeric) (41 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Proteinase-activated receptor 1 (Complex)
- G(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
Cryo-EM structure of the TRH-bound human TRHR-Gq complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7xw9
Q-score: 0.543
Ji SY, Dong YJ, Chen LN, Zang SK, Wang J, Shen DD, Guo J, Qin J, Zhang H, Wang WW, Shen Q, Zhang Y, Song Z, Mao C
Cell Discov (2022) 8 pp. 116-116 [ Pubmed: 36280665 DOI: doi:10.1038/s41421-022-00477-0 ]
- Thyrotropin-releasing hormone receptor (45 kDa, Protein from Homo sapiens)
- Trh peptide (362 Da, Protein from synthetic construct)
- Cryo-em structure of the trh-bound trhr-gq complex (180 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- G protein (Complex from Homo sapiens)
- Trh peptide (Complex)
- Thyrotropin-releasing hormone receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (46 kDa, Protein from Homo sapiens)
- Antibody (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Single fab chain (svfv16) (28 kDa, Protein from synthetic construct)