Cryo-EM of helical fibers formed by two peptides Pyn-K6 and Pyn-(EY)3
Resolution: 3.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 9d70
Q-score: 0.39
Qiao Y, Zia A, Wu G, Liu Z, Guo J, Chu M, He H, Wang F, Xu B
J Am Chem Soc (2025) 147 pp. 2978-2983 [ Pubmed: 39808585 DOI: doi:10.1021/jacs.4c12150 ]
- Pyn-k6 + pyn-ey3 fiber (Complex from synthetic construct)
- Pyr-k6 (1 kDa, Protein from synthetic construct)
- (pyren-1-yl)acetic acid (260 Da, Ligand)
- Pyr-ey3 (1 kDa, Protein from synthetic construct)
Resolution: 3.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 9bjn
Q-score: 0.56
Guo J, Zia A, Qiu Q, Norton M, Qiu K, Usuba J, Liu Z, Yi M, Rich-New ST, Hagan M, Fraden S, Han GD, Diao J, Wang F, Xu B
J Am Chem Soc (2024) 146 pp. 26102-26112 [ Pubmed: 39255453 DOI: doi:10.1021/jacs.4c06775 ]
- Ffspy fiber (Complex from synthetic construct)
- D-peptide ffspy (850 Da, Protein from synthetic construct)
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 9bjo
Q-score: 0.605
Guo J, Zia A, Qiu Q, Norton M, Qiu K, Usuba J, Liu Z, Yi M, Rich-New ST, Hagan M, Fraden S, Han GD, Diao J, Wang F, Xu B
J Am Chem Soc (2024) 146 pp. 26102-26112 [ Pubmed: 39255453 DOI: doi:10.1021/jacs.4c06775 ]
- D-peptide ffsy (770 Da, Protein from synthetic construct)
- Ffsy fiber (Complex from synthetic construct)
Cryo-EM structure of the WN561-bound human APLNR-Gi complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xzf
Q-score: 0.578
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Cryo-em structure of the wn561-bound human aplnr-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Wn561 (1 kDa, Protein from synthetic construct)
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of the MM07-bound human APLNR-Gi complex
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8xzh
Q-score: 0.649
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of the mm07-bound human aplnr-gi complex (Complex from Homo sapiens)
- Mm07 (1 kDa, Protein from synthetic construct)
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from synthetic construct)
Cryo-EM structure of the CMF-019-bound human APLNR-Gi complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8xzi
Q-score: 0.588
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- (3~{s})-5-methyl-3-[[1-pentan-3-yl-2-(thiophen-2-ylmethyl)benzimidazol-5-yl]carbonylamino]hexanoic acid (455 Da, Ligand)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of the cmf-019-bound human aplnr-gi complex (Complex from Homo sapiens)
Cryo-EM structure of the WN353-bound human APLNR-Gi complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xzj
Q-score: 0.509
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of the wn353-bound human aplnr-gi complex (Complex from Homo sapiens)
- Wn353 (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM of self-assembling pyrene peptide with Ca2+
Resolution: 3.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 8gi5
Q-score: 0.582
Guo J, Rich-New ST, Liu C, Huang Y, Tan W, He H, Yi M, Zhang X, Egelman EH, Wang F, Xu B
Chem (2023) 9 pp. 2530-2546 [ Pubmed: 38094164 DOI: doi:10.1016/j.chempr.2023.04.023 ]
- Pyrene peptide (1 kDa, Protein from synthetic construct)
- Pyrene peptide with ca2+ (Complex from synthetic construct)
Cryo-EM of NBD-ffsy filaments (class 2)
Resolution: 3.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 8dst
Q-score: 0.309
Guo J, Wang F, Huang Y, He H, Tan W, Yi M, Egelman EH, Xu B
Nat Nanotechnol (2023) 18 pp. 1094-1104 [ DOI: doi:10.1038/s41565-023-01401-7 Pubmed: 37217766 ]
- Nbd-ffsy peptide (796 Da, Protein from synthetic construct)
- Synthetic construct (Complex from synthetic construct)
Resolution: 2.6 Å
EM Method: Helical reconstruction
Fitted PDBs: 8fof
Q-score: 0.672
Guo J, Wang F, Huang Y, He H, Tan W, Yi M, Egelman EH, Xu B
Nat Nanotechnol (2023) 18 pp. 1094-1104 [ DOI: doi:10.1038/s41565-023-01401-7 Pubmed: 37217766 ]
- Bp-ffsy (742 Da, Protein from synthetic construct)
- Bp-ffsy (Complex from synthetic construct)