Cryo-EM structure of the TRH-bound human TRHR-Gq complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7xw9
Q-score: 0.543
Ji SY, Dong YJ, Chen LN, Zang SK, Wang J, Shen DD, Guo J, Qin J, Zhang H, Wang WW, Shen Q, Zhang Y, Song Z, Mao C
Cell Discov (2022) 8 pp. 116-116 [ Pubmed: 36280665 DOI: doi:10.1038/s41421-022-00477-0 ]
- Single fab chain (svfv16) (28 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Cryo-em structure of the trh-bound trhr-gq complex (180 kDa, Complex)
- Guanine nucleotide-binding protein g(q) subunit alpha (46 kDa, Protein from Homo sapiens)
- Trh peptide (362 Da, Protein from synthetic construct)
- Thyrotropin-releasing hormone receptor (45 kDa, Protein from Homo sapiens)
- Antibody (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Thyrotropin-releasing hormone receptor (Complex from Homo sapiens)
- G protein (Complex from Homo sapiens)
- Trh peptide (Complex)
Cryo-EM structure of the SS-14-bound human SSTR2-Gi1 complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7wic
Q-score: 0.509
Chen LN, Wang WW, Dong YJ, Shen DD, Guo J, Yu X, Qin J, Ji SY, Zhang H, Shen Q, He Q, Yang B, Zhang Y, Li Q, Mao C
Cell Res (2022) 32 pp. 785-788 [ DOI: doi:10.1038/s41422-022-00669-z Pubmed: 35578016 ]
- Single fab chain (svfv16) (28 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Cryo-em structure of the ss-14-bound sstr2-gi1 complex (180 kDa, Complex)
- Antibody (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Somatostatin receptor type 2 (Complex from Homo sapiens)
- G protein (Complex from Homo sapiens)
- Somatostatin receptor type 2 (41 kDa, Protein from Homo sapiens)
- Somatostatin-14 (1 kDa, Protein from Homo sapiens)
Cryo-EM structure of the L-054,264-bound human SSTR2-Gi1 complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7wig
Q-score: 0.527
Chen LN, Wang WW, Dong YJ, Shen DD, Guo J, Yu X, Qin J, Ji SY, Zhang H, Shen Q, He Q, Yang B, Zhang Y, Li Q, Mao C
Cell Res (2022) 32 pp. 785-788 [ DOI: doi:10.1038/s41422-022-00669-z Pubmed: 35578016 ]
- Cryo-em structure of the l-054,264-bound sstr2-gi1 complex (180 kDa, Complex)
- Single fab chain (svfv16) (28 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- ~{n}-[(2~{r})-1-[[(1~{r},3~{s})-3-(aminomethyl)cyclohexyl]methylamino]-3-(1~{h}-indol-3-yl)-1-oxidanylidene-propan-2-yl]spiro[indene-1,4'-piperidine]-1'-carboxamide (539 Da, Ligand)
- Antibody (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Somatostatin receptor type 2 (Complex from Homo sapiens)
- G protein (Complex from Homo sapiens)
- Somatostatin receptor type 2 (41 kDa, Protein from Homo sapiens)
Al-bound structure of the AtALMT1 mutant M60A
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7voj
Q-score: 0.504
Wang J, Yu X, Ding ZJ, Zhang X, Luo Y, Xu X, Xie Y, Li X, Yuan T, Zheng SJ, Yang W, Guo J
Cell Res (2022) 32 pp. 89-98 [ DOI: doi:10.1038/s41422-021-00587-6 Pubmed: 34799726 ]
- Acetic acid (60 Da, Ligand)
- Aluminum-activated malate transporter 1 (56 kDa, Protein from Arabidopsis thaliana)
- Aluminum ion (26 Da, Ligand)
- Al-bound protein sample of the atalmt1 mutant m60a (120 MDa, Complex from Arabidopsis thaliana)
Cryo-EM structure of human TMEM120A in the CoASH-free state
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7f3u
Q-score: 0.335
Rong Y, Jiang J, Gao Y, Guo J, Song D, Liu W, Zhang M, Zhao Y, Xiao B, Liu Z
eLife (2021) 10 [ DOI: doi:10.7554/eLife.71474 Pubmed: 34409941 ]
- Transmembrane protein 120a (Cell from Homo sapiens)
- Transmembrane protein 120a (44 kDa, Protein from Homo sapiens)
Cryo-EM structure of mouse TPC1 channel in the apo state
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6c96
Q-score: 0.456
She J, Guo J, Chen Q, Zeng W, Jiang Y, Bai XC
Nature (2018) 556 pp. 130-134 [ Pubmed: 29562233 DOI: doi:10.1038/nature26139 ]
- Sodium ion (22 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Apo mouse tpc1 (Cellular component from Mus musculus)
- Two pore calcium channel protein 1 (95 kDa, Protein from Mus musculus)
cryo-EM structure of TRPM4 in apo state with short coiled coil at 3.1 angstrom resolution
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 6bcj
Q-score: 0.502
Guo J, She J, Zeng W, Chen Q, Bai XC, Jiang Y
Nature (2017) 552 pp. 205-209 [ Pubmed: 29211714 DOI: doi:10.1038/nature24997 ]
- Homotetramer of mouse trpm4 (Complex from Mus musculus)
- Sodium ion (22 Da, Ligand)
- Water (18 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 4 (140 kDa, Protein from Mus musculus)
cryo-EM structure of TRPM4 in apo state with long coiled coil at 3.5 angstrom resolution
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 6bcl
Q-score: 0.43
Guo J, She J, Zeng W, Chen Q, Bai XC, Jiang Y
Nature (2017) 552 pp. 205-209 [ Pubmed: 29211714 DOI: doi:10.1038/nature24997 ]
- Homotetramer of mouse trpm4 (Complex from Mus musculus)
- Sodium ion (22 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 4 (140 kDa, Protein from Mus musculus)
cryo-EM structure of TRPM4 in ATP bound state with short coiled coil at 2.9 angstrom resolution
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 6bco
Q-score: 0.509
Guo J, She J, Zeng W, Chen Q, Bai XC, Jiang Y
Nature (2017) 552 pp. 205-209 [ Pubmed: 29211714 DOI: doi:10.1038/nature24997 ]
- Transient receptor potential cation channel subfamily m member 4 (140 kDa, Protein from Mus musculus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Homotetramer mouse trpm4 (Complex from Mus musculus)
cryo-EM structure of TRPM4 in ATP bound state with long coiled coil at 3.3 angstrom resolution
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 6bcq
Q-score: 0.433
Guo J, She J, Zeng W, Chen Q, Bai XC, Jiang Y
Nature (2017) 552 pp. 205-209 [ Pubmed: 29211714 DOI: doi:10.1038/nature24997 ]
- Homotetramer of mouse trpm4 (Complex from Mus musculus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 4 (140 kDa, Protein from Mus musculus)