Cryo-EM structure of the TRH-bound human TRHR-Gq complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7xw9
Q-score: 0.543
Ji SY, Dong YJ, Chen LN, Zang SK, Wang J, Shen DD, Guo J, Qin J, Zhang H, Wang WW, Shen Q, Zhang Y, Song Z, Mao C
Cell Discov (2022) 8 pp. 116-116 [ DOI: doi:10.1038/s41421-022-00477-0 Pubmed: 36280665 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cryo-em structure of the trh-bound trhr-gq complex (180 kDa, Complex)
- Single fab chain (svfv16) (28 kDa, Protein from synthetic construct)
- Antibody (Complex from synthetic construct)
- G protein (Complex from Homo sapiens)
- Thyrotropin-releasing hormone receptor (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (46 kDa, Protein from Homo sapiens)
- Trh peptide (362 Da, Protein from synthetic construct)
- Trh peptide (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Thyrotropin-releasing hormone receptor (Complex from Homo sapiens)
Cryo-EM structure of the SS-14-bound human SSTR2-Gi1 complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7wic
Q-score: 0.509
Chen LN, Wang WW, Dong YJ, Shen DD, Guo J, Yu X, Qin J, Ji SY, Zhang H, Shen Q, He Q, Yang B, Zhang Y, Li Q, Mao C
Cell Res (2022) 32 pp. 785-788 [ Pubmed: 35578016 DOI: doi:10.1038/s41422-022-00669-z ]
- Cryo-em structure of the ss-14-bound sstr2-gi1 complex (180 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Single fab chain (svfv16) (28 kDa, Protein from synthetic construct)
- Somatostatin receptor type 2 (Complex from Homo sapiens)
- Antibody (Complex from synthetic construct)
- G protein (Complex from Homo sapiens)
- Somatostatin receptor type 2 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Somatostatin-14 (1 kDa, Protein from Homo sapiens)
Cryo-EM structure of the L-054,264-bound human SSTR2-Gi1 complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7wig
Q-score: 0.527
Chen LN, Wang WW, Dong YJ, Shen DD, Guo J, Yu X, Qin J, Ji SY, Zhang H, Shen Q, He Q, Yang B, Zhang Y, Li Q, Mao C
Cell Res (2022) 32 pp. 785-788 [ Pubmed: 35578016 DOI: doi:10.1038/s41422-022-00669-z ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Single fab chain (svfv16) (28 kDa, Protein from synthetic construct)
- Somatostatin receptor type 2 (Complex from Homo sapiens)
- G protein (Complex from Homo sapiens)
- Antibody (Complex from synthetic construct)
- Somatostatin receptor type 2 (41 kDa, Protein from Homo sapiens)
- Cryo-em structure of the l-054,264-bound sstr2-gi1 complex (180 kDa, Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- ~{n}-[(2~{r})-1-[[(1~{r},3~{s})-3-(aminomethyl)cyclohexyl]methylamino]-3-(1~{h}-indol-3-yl)-1-oxidanylidene-propan-2-yl]spiro[indene-1,4'-piperidine]-1'-carboxamide (539 Da, Ligand)